CYCLIC PURINE DINUCLEOTIDES AS MODULATORS OF STING
A compound of Formula (I) wherein Y 1, Y2, X 1, X 2, R 1, R 2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also r...
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| creator | DUFFY, Kevin J LIAN, Yiqian ADAMS, Jerry Leroy |
| description | A compound of Formula (I) wherein Y 1, Y2, X 1, X 2, R 1, R 2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.
Cette invention concerne un composé de Formule (I) où Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, et R9 sont tels que définis dans la description ; et des sels pharmaceutiquement acceptables et des tautomères de celui-ci, des compositions, des combinaisons et des médicaments les contenant et leurs procédés de préparation. L'utilisation desdits composés, combinaisons, compositions et médicaments dans le traitement de maladies dans lesquelles la modulation du STING (stimulateur des gènes de l'interféron) est bénéfique, par exemple l'inflammation, les maladies allergiques et auto-immunes, les maladies infectieuses, le cancer, les syndromes pré-cancéreux, et à titre d'adjuvants de vaccins, est en outre décrite. |
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Cette invention concerne un composé de Formule (I) où Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, et R9 sont tels que définis dans la description ; et des sels pharmaceutiquement acceptables et des tautomères de celui-ci, des compositions, des combinaisons et des médicaments les contenant et leurs procédés de préparation. L'utilisation desdits composés, combinaisons, compositions et médicaments dans le traitement de maladies dans lesquelles la modulation du STING (stimulateur des gènes de l'interféron) est bénéfique, par exemple l'inflammation, les maladies allergiques et auto-immunes, les maladies infectieuses, le cancer, les syndromes pré-cancéreux, et à titre d'adjuvants de vaccins, est en outre décrite.</description><language>eng ; fre</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170608&DB=EPODOC&CC=WO&NR=2017093933A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170608&DB=EPODOC&CC=WO&NR=2017093933A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DUFFY, Kevin J</creatorcontrib><creatorcontrib>LIAN, Yiqian</creatorcontrib><creatorcontrib>ADAMS, Jerry Leroy</creatorcontrib><title>CYCLIC PURINE DINUCLEOTIDES AS MODULATORS OF STING</title><description>A compound of Formula (I) wherein Y 1, Y2, X 1, X 2, R 1, R 2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.
Cette invention concerne un composé de Formule (I) où Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, et R9 sont tels que définis dans la description ; et des sels pharmaceutiquement acceptables et des tautomères de celui-ci, des compositions, des combinaisons et des médicaments les contenant et leurs procédés de préparation. L'utilisation desdits composés, combinaisons, compositions et médicaments dans le traitement de maladies dans lesquelles la modulation du STING (stimulateur des gènes de l'interféron) est bénéfique, par exemple l'inflammation, les maladies allergiques et auto-immunes, les maladies infectieuses, le cancer, les syndromes pré-cancéreux, et à titre d'adjuvants de vaccins, est en outre décrite.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDByjnT28XRWCAgN8vRzVXDx9At19nH1D_F0cQ1WcAxW8PV3CfVxDPEPClbwd1MIDvH0c-dhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGhuYGlsaWxsaOhsbEqQIAII0n4Q</recordid><startdate>20170608</startdate><enddate>20170608</enddate><creator>DUFFY, Kevin J</creator><creator>LIAN, Yiqian</creator><creator>ADAMS, Jerry Leroy</creator><scope>EVB</scope></search><sort><creationdate>20170608</creationdate><title>CYCLIC PURINE DINUCLEOTIDES AS MODULATORS OF STING</title><author>DUFFY, Kevin J ; LIAN, Yiqian ; ADAMS, Jerry Leroy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2017093933A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>DUFFY, Kevin J</creatorcontrib><creatorcontrib>LIAN, Yiqian</creatorcontrib><creatorcontrib>ADAMS, Jerry Leroy</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DUFFY, Kevin J</au><au>LIAN, Yiqian</au><au>ADAMS, Jerry Leroy</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CYCLIC PURINE DINUCLEOTIDES AS MODULATORS OF STING</title><date>2017-06-08</date><risdate>2017</risdate><abstract>A compound of Formula (I) wherein Y 1, Y2, X 1, X 2, R 1, R 2, R3, R4, R5, R6, R8, and R9 are as defined herein; and pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.
Cette invention concerne un composé de Formule (I) où Y1, Y2, X1, X2, R1, R2, R3, R4, R5, R6, R8, et R9 sont tels que définis dans la description ; et des sels pharmaceutiquement acceptables et des tautomères de celui-ci, des compositions, des combinaisons et des médicaments les contenant et leurs procédés de préparation. L'utilisation desdits composés, combinaisons, compositions et médicaments dans le traitement de maladies dans lesquelles la modulation du STING (stimulateur des gènes de l'interféron) est bénéfique, par exemple l'inflammation, les maladies allergiques et auto-immunes, les maladies infectieuses, le cancer, les syndromes pré-cancéreux, et à titre d'adjuvants de vaccins, est en outre décrite.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | CYCLIC PURINE DINUCLEOTIDES AS MODULATORS OF STING |
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