EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula (I) compounds X, Y, R1, R2, R3a, R3b, R4a, R4b and R5 are as defined in the spec...
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| creator | TRAN, Chinh PACKARD, Garrick, Kenneth REICH, Siegfried, H NILEWSKI, Christian XIANG, Alan, Xin ERNST, Justin, T MICHELS, Theodore SPRENGELER, Paul, A |
| description | The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula (I) compounds X, Y, R1, R2, R3a, R3b, R4a, R4b and R5 are as defined in the specification. The inventive Formula (I) compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.
La présente invention concerne la synthèse, des formulations pharmaceutiquement acceptables et des utilisations de composés selon la formule I, ou d'un stéréo-isomère, d'un tautomère ou d'un sel pharmaceutiquement acceptable de ceux-ci. Dans la formule (I), les composés X, Y, R1, R2, R3a, R3b, R4a, R4b et R5 sont tels que définis dans la description. Lesdits composés de formule (I) selon l'invention sont des inhibiteurs de eIF4A et s'avèrent utiles dans un grand nombre d'applications thérapeutiques, notamment mais pas exclusivement dans le traitement de l'inflammation et de divers cancers. |
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La présente invention concerne la synthèse, des formulations pharmaceutiquement acceptables et des utilisations de composés selon la formule I, ou d'un stéréo-isomère, d'un tautomère ou d'un sel pharmaceutiquement acceptable de ceux-ci. Dans la formule (I), les composés X, Y, R1, R2, R3a, R3b, R4a, R4b et R5 sont tels que définis dans la description. Lesdits composés de formule (I) selon l'invention sont des inhibiteurs de eIF4A et s'avèrent utiles dans un grand nombre d'applications thérapeutiques, notamment mais pas exclusivement dans le traitement de l'inflammation et de divers cancers.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170601&DB=EPODOC&CC=WO&NR=2017091585A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170601&DB=EPODOC&CC=WO&NR=2017091585A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TRAN, Chinh</creatorcontrib><creatorcontrib>PACKARD, Garrick, Kenneth</creatorcontrib><creatorcontrib>REICH, Siegfried, H</creatorcontrib><creatorcontrib>NILEWSKI, Christian</creatorcontrib><creatorcontrib>XIANG, Alan, Xin</creatorcontrib><creatorcontrib>ERNST, Justin, T</creatorcontrib><creatorcontrib>MICHELS, Theodore</creatorcontrib><creatorcontrib>SPRENGELER, Paul, A</creatorcontrib><title>EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO</title><description>The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula (I) compounds X, Y, R1, R2, R3a, R3b, R4a, R4b and R5 are as defined in the specification. The inventive Formula (I) compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.
La présente invention concerne la synthèse, des formulations pharmaceutiquement acceptables et des utilisations de composés selon la formule I, ou d'un stéréo-isomère, d'un tautomère ou d'un sel pharmaceutiquement acceptable de ceux-ci. Dans la formule (I), les composés X, Y, R1, R2, R3a, R3b, R4a, R4b et R5 sont tels que définis dans la description. Lesdits composés de formule (I) selon l'invention sont des inhibiteurs de eIF4A et s'avèrent utiles dans un grand nombre d'applications thérapeutiques, notamment mais pas exclusivement dans le traitement de l'inflammation et de divers cancers.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB39XQz0XXU9fTz8HTyDPH0c1dw9vcN8A_1cwlWcPRzUfB1DfHwB7KDXH0cQ1xdFEI8XINcQ_x5GFjTEnOKU3mhNDeDsptriLOHbmpBfnxqcUFicmpeakl8uL-RgaG5gaWhqYWpo6ExcaoAwvko_Q</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>TRAN, Chinh</creator><creator>PACKARD, Garrick, Kenneth</creator><creator>REICH, Siegfried, H</creator><creator>NILEWSKI, Christian</creator><creator>XIANG, Alan, Xin</creator><creator>ERNST, Justin, T</creator><creator>MICHELS, Theodore</creator><creator>SPRENGELER, Paul, A</creator><scope>EVB</scope></search><sort><creationdate>20170601</creationdate><title>EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO</title><author>TRAN, Chinh ; PACKARD, Garrick, Kenneth ; REICH, Siegfried, H ; NILEWSKI, Christian ; XIANG, Alan, Xin ; ERNST, Justin, T ; MICHELS, Theodore ; SPRENGELER, Paul, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2017091585A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>TRAN, Chinh</creatorcontrib><creatorcontrib>PACKARD, Garrick, Kenneth</creatorcontrib><creatorcontrib>REICH, Siegfried, H</creatorcontrib><creatorcontrib>NILEWSKI, Christian</creatorcontrib><creatorcontrib>XIANG, Alan, Xin</creatorcontrib><creatorcontrib>ERNST, Justin, T</creatorcontrib><creatorcontrib>MICHELS, Theodore</creatorcontrib><creatorcontrib>SPRENGELER, Paul, A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TRAN, Chinh</au><au>PACKARD, Garrick, Kenneth</au><au>REICH, Siegfried, H</au><au>NILEWSKI, Christian</au><au>XIANG, Alan, Xin</au><au>ERNST, Justin, T</au><au>MICHELS, Theodore</au><au>SPRENGELER, Paul, A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO</title><date>2017-06-01</date><risdate>2017</risdate><abstract>The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula (I) compounds X, Y, R1, R2, R3a, R3b, R4a, R4b and R5 are as defined in the specification. The inventive Formula (I) compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.
La présente invention concerne la synthèse, des formulations pharmaceutiquement acceptables et des utilisations de composés selon la formule I, ou d'un stéréo-isomère, d'un tautomère ou d'un sel pharmaceutiquement acceptable de ceux-ci. Dans la formule (I), les composés X, Y, R1, R2, R3a, R3b, R4a, R4b et R5 sont tels que définis dans la description. Lesdits composés de formule (I) selon l'invention sont des inhibiteurs de eIF4A et s'avèrent utiles dans un grand nombre d'applications thérapeutiques, notamment mais pas exclusivement dans le traitement de l'inflammation et de divers cancers.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO |
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