CO-CRYSTALS OF BENZIMIDAZOLE COMPOUNDS
The invention relates to a cocrystal comprising a) at least bilastine and, b) at least a cocrystal forming compound selected from the group consisting of glutaric acid, adipic acid, sorbic acid, succinic acid, benzoic acid, 4-aminobenzoic acid, L-malic acid, resorcinol, methyl 4-hydroxy benzoate and...
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| creator | JIMÉNEZ GONZÁLEZ, Carme GARCÍA DOMÍNGUEZ, Neftalí CANAL MORI, Gonzalo HERNÁNDEZ HERRERO, Gonzalo RUBIO ROYO, Víctor TESSON, Nicolas DE MIER VINUE, Jordi |
| description | The invention relates to a cocrystal comprising a) at least bilastine and, b) at least a cocrystal forming compound selected from the group consisting of glutaric acid, adipic acid, sorbic acid, succinic acid, benzoic acid, 4-aminobenzoic acid, L-malic acid, resorcinol, methyl 4-hydroxy benzoate and N-(4- hydroxyphenyl)acetamide and mixtures thereof, or a solvate thereof. The invention further relates to methods for obtaining said cocrystals and to their use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases. The invention also relates to a method for increase the aqueous solubility of the above compounds of formula (I).
L'invention concerne un cocristal comprenant: a) au moins de la bilastine; et b) au moins un composé de formation de co-cristal choisi dans le groupe constitué par l'acide glutarique, l'acide adipique, l'acide sorbique, l'acide succinique, l'acide benzoïque, l'acide 4-aminobenzoïque, l'acide L-malique, le résorcinol, le 4-hydroxy benzoate et le N-(4-hydroxyphényl)acétamide ainsi que leurs mélanges; ou un solvate de celui-ci. L'invention concerne également des procédés d'obtention desdits cocristaux, et leur utilisation dans le traitement et/ou la prévention d'états médiés par le récepteur H1 de l'histamine, tels que les troubles ou maladies allergiques. L'invention concerne également un procédé pour augmenter la solubilité aqueuse des composés de formule (I) ci-dessus. |
| format | Patent |
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L'invention concerne un cocristal comprenant: a) au moins de la bilastine; et b) au moins un composé de formation de co-cristal choisi dans le groupe constitué par l'acide glutarique, l'acide adipique, l'acide sorbique, l'acide succinique, l'acide benzoïque, l'acide 4-aminobenzoïque, l'acide L-malique, le résorcinol, le 4-hydroxy benzoate et le N-(4-hydroxyphényl)acétamide ainsi que leurs mélanges; ou un solvate de celui-ci. L'invention concerne également des procédés d'obtention desdits cocristaux, et leur utilisation dans le traitement et/ou la prévention d'états médiés par le récepteur H1 de l'histamine, tels que les troubles ou maladies allergiques. L'invention concerne également un procédé pour augmenter la solubilité aqueuse des composés de formule (I) ci-dessus.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170526&DB=EPODOC&CC=WO&NR=2017085258A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170526&DB=EPODOC&CC=WO&NR=2017085258A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JIMÉNEZ GONZÁLEZ, Carme</creatorcontrib><creatorcontrib>GARCÍA DOMÍNGUEZ, Neftalí</creatorcontrib><creatorcontrib>CANAL MORI, Gonzalo</creatorcontrib><creatorcontrib>HERNÁNDEZ HERRERO, Gonzalo</creatorcontrib><creatorcontrib>RUBIO ROYO, Víctor</creatorcontrib><creatorcontrib>TESSON, Nicolas</creatorcontrib><creatorcontrib>DE MIER VINUE, Jordi</creatorcontrib><title>CO-CRYSTALS OF BENZIMIDAZOLE COMPOUNDS</title><description>The invention relates to a cocrystal comprising a) at least bilastine and, b) at least a cocrystal forming compound selected from the group consisting of glutaric acid, adipic acid, sorbic acid, succinic acid, benzoic acid, 4-aminobenzoic acid, L-malic acid, resorcinol, methyl 4-hydroxy benzoate and N-(4- hydroxyphenyl)acetamide and mixtures thereof, or a solvate thereof. The invention further relates to methods for obtaining said cocrystals and to their use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases. The invention also relates to a method for increase the aqueous solubility of the above compounds of formula (I).
L'invention concerne un cocristal comprenant: a) au moins de la bilastine; et b) au moins un composé de formation de co-cristal choisi dans le groupe constitué par l'acide glutarique, l'acide adipique, l'acide sorbique, l'acide succinique, l'acide benzoïque, l'acide 4-aminobenzoïque, l'acide L-malique, le résorcinol, le 4-hydroxy benzoate et le N-(4-hydroxyphényl)acétamide ainsi que leurs mélanges; ou un solvate de celui-ci. L'invention concerne également des procédés d'obtention desdits cocristaux, et leur utilisation dans le traitement et/ou la prévention d'états médiés par le récepteur H1 de l'histamine, tels que les troubles ou maladies allergiques. L'invention concerne également un procédé pour augmenter la solubilité aqueuse des composés de formule (I) ci-dessus.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBz9td1DooMDnH0CVbwd1NwcvWL8vT1dHGM8vdxVXD29w3wD_VzCeZhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGhuYGFqZGphaOhsbEqQIAZYkktw</recordid><startdate>20170526</startdate><enddate>20170526</enddate><creator>JIMÉNEZ GONZÁLEZ, Carme</creator><creator>GARCÍA DOMÍNGUEZ, Neftalí</creator><creator>CANAL MORI, Gonzalo</creator><creator>HERNÁNDEZ HERRERO, Gonzalo</creator><creator>RUBIO ROYO, Víctor</creator><creator>TESSON, Nicolas</creator><creator>DE MIER VINUE, Jordi</creator><scope>EVB</scope></search><sort><creationdate>20170526</creationdate><title>CO-CRYSTALS OF BENZIMIDAZOLE COMPOUNDS</title><author>JIMÉNEZ GONZÁLEZ, Carme ; GARCÍA DOMÍNGUEZ, Neftalí ; CANAL MORI, Gonzalo ; HERNÁNDEZ HERRERO, Gonzalo ; RUBIO ROYO, Víctor ; TESSON, Nicolas ; DE MIER VINUE, Jordi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2017085258A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JIMÉNEZ GONZÁLEZ, Carme</creatorcontrib><creatorcontrib>GARCÍA DOMÍNGUEZ, Neftalí</creatorcontrib><creatorcontrib>CANAL MORI, Gonzalo</creatorcontrib><creatorcontrib>HERNÁNDEZ HERRERO, Gonzalo</creatorcontrib><creatorcontrib>RUBIO ROYO, Víctor</creatorcontrib><creatorcontrib>TESSON, Nicolas</creatorcontrib><creatorcontrib>DE MIER VINUE, Jordi</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JIMÉNEZ GONZÁLEZ, Carme</au><au>GARCÍA DOMÍNGUEZ, Neftalí</au><au>CANAL MORI, Gonzalo</au><au>HERNÁNDEZ HERRERO, Gonzalo</au><au>RUBIO ROYO, Víctor</au><au>TESSON, Nicolas</au><au>DE MIER VINUE, Jordi</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CO-CRYSTALS OF BENZIMIDAZOLE COMPOUNDS</title><date>2017-05-26</date><risdate>2017</risdate><abstract>The invention relates to a cocrystal comprising a) at least bilastine and, b) at least a cocrystal forming compound selected from the group consisting of glutaric acid, adipic acid, sorbic acid, succinic acid, benzoic acid, 4-aminobenzoic acid, L-malic acid, resorcinol, methyl 4-hydroxy benzoate and N-(4- hydroxyphenyl)acetamide and mixtures thereof, or a solvate thereof. The invention further relates to methods for obtaining said cocrystals and to their use in the treatment and/or prevention of conditions mediated by H1 histamine receptor, such as allergic disorders or diseases. The invention also relates to a method for increase the aqueous solubility of the above compounds of formula (I).
L'invention concerne un cocristal comprenant: a) au moins de la bilastine; et b) au moins un composé de formation de co-cristal choisi dans le groupe constitué par l'acide glutarique, l'acide adipique, l'acide sorbique, l'acide succinique, l'acide benzoïque, l'acide 4-aminobenzoïque, l'acide L-malique, le résorcinol, le 4-hydroxy benzoate et le N-(4-hydroxyphényl)acétamide ainsi que leurs mélanges; ou un solvate de celui-ci. L'invention concerne également des procédés d'obtention desdits cocristaux, et leur utilisation dans le traitement et/ou la prévention d'états médiés par le récepteur H1 de l'histamine, tels que les troubles ou maladies allergiques. L'invention concerne également un procédé pour augmenter la solubilité aqueuse des composés de formule (I) ci-dessus.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CO-CRYSTALS OF BENZIMIDAZOLE COMPOUNDS |
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