HINGE MODIFIED ANTIBODY FRAGMENTS AND METHODS OF MAKING

HINGE MODIFIED ANTIBODY FRAGMENTS AND METHODS OF MAKING

The instant disclosure provides antibody fragments (e.g., Fab and F(ab')2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions. La pr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KIM, Ingrid, MENG, Yu-Ju, G, SPIESS, Christoph, KIM, Hok, Seon
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The instant disclosure provides antibody fragments (e.g., Fab and F(ab')2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions. La présente invention concerne des fragments d'anticorps (par ex., Fab et F(ab')2) présentant peu ou pas de réactivité vis-à-vis d'anticorps anti-charnière (AHA) préexistants et des compositions comprenant ces fragments d'anticorps, ainsi que des procédés de fabrication et d'utilisation de ces fragments d'anticorps et compositions.