CHK1/2 INHIBITORS FOR USE IN THE TREATMENT OF NEUROBLASTOMAS AND/OR SOFT TISSUE SARCOMAS

The present invention provides 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-lH- pyrazol-3-ylamino)pyrazine~2~carbonitrile and pharmaceutically acceptable salts and solvates thereof, that is capable of inhibiting CHK1 and is useful in the treatment of neuroblastomas and/or soft tissue sarcomas. La prése...

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Bibliographische Detailangaben
1. Verfasser:	STANCATO, Louis Frank
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-lH- pyrazol-3-ylamino)pyrazine~2~carbonitrile and pharmaceutically acceptable salts and solvates thereof, that is capable of inhibiting CHK1 and is useful in the treatment of neuroblastomas and/or soft tissue sarcomas. La présente invention concerne un 5-(5-(2-(3-aminopropoxy)-6-méthoxyphényl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, ainsi que des sels et solvates pharmaceutiquement acceptables de celui-ci, qui peut inhiber le CHK1 et est utile dans le traitement de neuroblastomes et/ou de sarcomes des tissus mous.