FUSED IMIDAZOLES AS MIDH1 INHIBITORS
The present invention relates to compounds of general formula (I) : in which R1, R2, R3, R4, R6, R7, R8, R9, R10, R11, R12, R13 and X are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combi...
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| creator | PANKNIN, Olaf REHWINKEL, Hartmut ZORN, Ludwig NGUYEN, Duy ZIMMERMANN, Katja HELFRICH, Petra HARTUNG, Ingo NEUHAUS, Roland |
| description | The present invention relates to compounds of general formula (I) : in which R1, R2, R3, R4, R6, R7, R8, R9, R10, R11, R12, R13 and X are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
La présente invention concerne des composés représentés par la formule générale (I) : dans laquelle , R1, R2, R3, R4, R6, R7, R8, R9, R10, R11, R12, R13 et X sont tels que définis dans l'invention, des procédés de préparation desdits composés, des composés intermédiaires utiles pour préparer lesdits composés, des compositions pharmaceutiques et des combinaisons comprenant lesdits composés, ainsi que l'utilisation desdits composés pour fabriquer une composition pharmaceutique destinée au traitement ou à la prophylaxie d'une maladie, en particulier de néoplasmes, en tant que seul agent ou en combinaison avec d'autres ingrédients actifs. |
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La présente invention concerne des composés représentés par la formule générale (I) : dans laquelle , R1, R2, R3, R4, R6, R7, R8, R9, R10, R11, R12, R13 et X sont tels que définis dans l'invention, des procédés de préparation desdits composés, des composés intermédiaires utiles pour préparer lesdits composés, des compositions pharmaceutiques et des combinaisons comprenant lesdits composés, ainsi que l'utilisation desdits composés pour fabriquer une composition pharmaceutique destinée au traitement ou à la prophylaxie d'une maladie, en particulier de néoplasmes, en tant que seul agent ou en combinaison avec d'autres ingrédients actifs.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170126&DB=EPODOC&CC=WO&NR=2017012967A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170126&DB=EPODOC&CC=WO&NR=2017012967A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PANKNIN, Olaf</creatorcontrib><creatorcontrib>REHWINKEL, Hartmut</creatorcontrib><creatorcontrib>ZORN, Ludwig</creatorcontrib><creatorcontrib>NGUYEN, Duy</creatorcontrib><creatorcontrib>ZIMMERMANN, Katja</creatorcontrib><creatorcontrib>HELFRICH, Petra</creatorcontrib><creatorcontrib>HARTUNG, Ingo</creatorcontrib><creatorcontrib>NEUHAUS, Roland</creatorcontrib><title>FUSED IMIDAZOLES AS MIDH1 INHIBITORS</title><description>The present invention relates to compounds of general formula (I) : in which R1, R2, R3, R4, R6, R7, R8, R9, R10, R11, R12, R13 and X are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
La présente invention concerne des composés représentés par la formule générale (I) : dans laquelle , R1, R2, R3, R4, R6, R7, R8, R9, R10, R11, R12, R13 et X sont tels que définis dans l'invention, des procédés de préparation desdits composés, des composés intermédiaires utiles pour préparer lesdits composés, des compositions pharmaceutiques et des combinaisons comprenant lesdits composés, ainsi que l'utilisation desdits composés pour fabriquer une composition pharmaceutique destinée au traitement ou à la prophylaxie d'une maladie, en particulier de néoplasmes, en tant que seul agent ou en combinaison avec d'autres ingrédients actifs.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBxCw12dVHw9PV0cYzy93ENVnAMVgByPAwVPP08PJ08Q_yDgnkYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXy4v5GBobmBoZGlmbmjoTFxqgD39CPL</recordid><startdate>20170126</startdate><enddate>20170126</enddate><creator>PANKNIN, Olaf</creator><creator>REHWINKEL, Hartmut</creator><creator>ZORN, Ludwig</creator><creator>NGUYEN, Duy</creator><creator>ZIMMERMANN, Katja</creator><creator>HELFRICH, Petra</creator><creator>HARTUNG, Ingo</creator><creator>NEUHAUS, Roland</creator><scope>EVB</scope></search><sort><creationdate>20170126</creationdate><title>FUSED IMIDAZOLES AS MIDH1 INHIBITORS</title><author>PANKNIN, Olaf ; REHWINKEL, Hartmut ; ZORN, Ludwig ; NGUYEN, Duy ; ZIMMERMANN, Katja ; HELFRICH, Petra ; HARTUNG, Ingo ; NEUHAUS, Roland</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2017012967A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PANKNIN, Olaf</creatorcontrib><creatorcontrib>REHWINKEL, Hartmut</creatorcontrib><creatorcontrib>ZORN, Ludwig</creatorcontrib><creatorcontrib>NGUYEN, Duy</creatorcontrib><creatorcontrib>ZIMMERMANN, Katja</creatorcontrib><creatorcontrib>HELFRICH, Petra</creatorcontrib><creatorcontrib>HARTUNG, Ingo</creatorcontrib><creatorcontrib>NEUHAUS, Roland</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PANKNIN, Olaf</au><au>REHWINKEL, Hartmut</au><au>ZORN, Ludwig</au><au>NGUYEN, Duy</au><au>ZIMMERMANN, Katja</au><au>HELFRICH, Petra</au><au>HARTUNG, Ingo</au><au>NEUHAUS, Roland</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FUSED IMIDAZOLES AS MIDH1 INHIBITORS</title><date>2017-01-26</date><risdate>2017</risdate><abstract>The present invention relates to compounds of general formula (I) : in which R1, R2, R3, R4, R6, R7, R8, R9, R10, R11, R12, R13 and X are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
La présente invention concerne des composés représentés par la formule générale (I) : dans laquelle , R1, R2, R3, R4, R6, R7, R8, R9, R10, R11, R12, R13 et X sont tels que définis dans l'invention, des procédés de préparation desdits composés, des composés intermédiaires utiles pour préparer lesdits composés, des compositions pharmaceutiques et des combinaisons comprenant lesdits composés, ainsi que l'utilisation desdits composés pour fabriquer une composition pharmaceutique destinée au traitement ou à la prophylaxie d'une maladie, en particulier de néoplasmes, en tant que seul agent ou en combinaison avec d'autres ingrédients actifs.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | FUSED IMIDAZOLES AS MIDH1 INHIBITORS |
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