GENE SIGNATURES PREDICTIVE OF METASTATIC DISEASE
Methods for characterising and/or prognosing cancer in a subject comprise determining the expression level of at least one, and preferably 12, genes selected from Table 1 in a sample from the subject wherein the determined expression level is used to provide a characterisation of and/or a prognosis...
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| creator | HILL, Laura WALKER, Steven PRICE, Bethanie DONEGAN, Sinead DAVISON, Timothy MCCAVIGAN, Andrena KENNEDY, Richard HARKIN, Denis Paul |
| description | Methods for characterising and/or prognosing cancer in a subject comprise determining the expression level of at least one, and preferably 12, genes selected from Table 1 in a sample from the subject wherein the determined expression level is used to provide a characterisation of and/or a prognosis for the cancer. Determined expression levels are used to generate a signature score. The methods permit metastatic disease to be identified and monitored and guide therapeutic interventions.
L'invention concerne des procédés permettant de caractériser et/ou de pronostiquer un cancer chez un sujet, comprenant la détermination du niveau d'expression d'au moins un, et de préférence de douze, des gènes sélectionnés à partir du tableau 1 dans un échantillon provenant du sujet, le niveau d'expression déterminé étant utilisé pour fournir une caractérisation et/ou un pronostic pour le cancer. Des niveaux d'expression déterminés sont utilisés pour générer un score de signature. Les procédés permettent d'identifier et de surveiller une maladie métastatique et de guider des interventions thérapeutiques. |
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L'invention concerne des procédés permettant de caractériser et/ou de pronostiquer un cancer chez un sujet, comprenant la détermination du niveau d'expression d'au moins un, et de préférence de douze, des gènes sélectionnés à partir du tableau 1 dans un échantillon provenant du sujet, le niveau d'expression déterminé étant utilisé pour fournir une caractérisation et/ou un pronostic pour le cancer. Des niveaux d'expression déterminés sont utilisés pour générer un score de signature. Les procédés permettent d'identifier et de surveiller une maladie métastatique et de guider des interventions thérapeutiques.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | GENE SIGNATURES PREDICTIVE OF METASTATIC DISEASE |
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