IMPROVED METHOD FOR PRODUCTION OF γ-CARBOXYLATED POLYPEPTIDES

The present invention pertains to methods for producing a γ-carboxylated polypeptide by a host cell having γ-glutamyl carboxylase activity. The production is improved by the presence of vitamin K and cyclodextrin in the cell culture medium. La présente invention se rapporte à des procédés de product...

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Bibliographische Detailangaben
Hauptverfasser:	JAHN, Doreen, STAHN, Rainer, GOLETZ, Steffen
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention pertains to methods for producing a γ-carboxylated polypeptide by a host cell having γ-glutamyl carboxylase activity. The production is improved by the presence of vitamin K and cyclodextrin in the cell culture medium. La présente invention se rapporte à des procédés de production d'un polypeptide γ-carboxylé par une cellule hôte ayant l'activité γ-glutamyl carboxylase. La production est améliorée par la présence de vitamine K et de cyclodextrine dans le milieu de culture cellulaire.