GENETIC MARKERS AND TREATMENT OF MALE OBESITY

Some aspects of this disclosure provide methods for treating obesity in subjects carrying a variant allele of the carboxypeptidase D (CPD) gene with perindopril, or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, hydrate, or solvate thereof; a compound of Formula II, or a phar...

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Bibliographische Detailangaben
Hauptverfasser:	TOMÉ FRANCISCO, Ana Patrícia, DA SILVA VICTOR, Bruno Lourenço, OLIVEIRA DE ALMEIDA BRANCO, Joana, DE ALMEIDA SANTOS VIDEIRA, Rita Margarida, VIEIRA MARTINS MOUTELLA, Teresa Maria, FREITAS BENTO, Guida José, DA SILVA CUNHA, Bibiana Carolina, RODRIGUES FAUSTINO, Nuno André, GOMES SILVESTRE VINHAS, Raquel Patrícia
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Some aspects of this disclosure provide methods for treating obesity in subjects carrying a variant allele of the carboxypeptidase D (CPD) gene with perindopril, or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, hydrate, or solvate thereof; a compound of Formula II, or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, hydrate, or solvate thereof; or a compound of Formulae III-V, or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, hydrate, or solvate thereof. Some aspects of this disclosure also provide methods for identifying a subject predisposed to obesity and/or sensitive to treatment with perindopril; a compound of Formula II, or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, hydrate, or solvate thereof; or a compound of Formulae III- V, or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, hydrate, or solvate thereof based on the subject carrying a variant allele of the CPD gene. Pharmaceutical compositions for treating obesity and kits for detecting a variant allele of the CPD gene and/or for identifying a subject who is predisposed to obesity or who would benefit from treatment with perindopril; a compound of Formula II, or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, hydrate, or solvate thereof; or a compound of Formulae III- V, or a pharmaceutically acceptable salt, stereoisomer, tautomer, polymorph, hydrate, or solvate thereof are also provided. La présente invention concerne, dans certains aspects, des méthodes de traitement de l'obésité chez des sujets portant un allèle variant du gène de la carboxypeptidase D (CPD) avec le périndopril, ou son stéréoisomère, son tautomère, son polymorphe, son hydrate, son solvate ou son sel pharmaceutiquement acceptable ; un composé de formule II, ou son stéréoisomère, son tautomère, son polymorphe, son hydrate, son solvate ou son sel pharmaceutiquement acceptable ; ou un composé de formules III à V, ou son stéréoisomère, son tautomère, son polymorphe, son hydrate, son solvate ou son sel pharmaceutiquement acceptable. Certains aspects de la présente invention concernent également des procédés permettant d'identifier un sujet prédisposé à l'obésité et/ou sensible au traitement avec périndopril ; un composé de formule II, ou son stéréoisomère, son tautomère, son polymorphe, son hydrate, son solvate ou son sel pharmaceutiquement acceptable ; ou un composé de formules III à V, ou