QUINAZOLINE AND QUINOLINE COMPOUNDS AND USES THEREOF
This invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein T, J, R, R4, Rq, o, RA, W and RB and subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions,...
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| creator | GIGSTAD, KENNETH, M LEE, HONG, MYUNG VYSKOCIL, STEPAN SHI, ZHAN FREEZE, BRIAN, SCOTT JANOWICK, DAVID, A SOUCY, FRANCOIS |
| description | This invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein T, J, R, R4, Rq, o, RA, W and RB and subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions, and/or T-cell mediated autoimmune disease.
La présente invention concerne des composés de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci. Dans la formule (I), T, J, R, R4, Rq, o, RA, W et RB, et des sous-ensembles de ceux-ci sont tels que décrits dans la description. Lesdits composés sont des inhibiteurs de NAMPT et sont ainsi utiles pour le traitement du cancer, d'états inflammatoires et/ou d'une maladie auto-immune médies par des lymphocytes T. |
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La présente invention concerne des composés de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci. Dans la formule (I), T, J, R, R4, Rq, o, RA, W et RB, et des sous-ensembles de ceux-ci sont tels que décrits dans la description. Lesdits composés sont des inhibiteurs de NAMPT et sont ainsi utiles pour le traitement du cancer, d'états inflammatoires et/ou d'une maladie auto-immune médies par des lymphocytes T.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160728&DB=EPODOC&CC=WO&NR=2016118565A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160728&DB=EPODOC&CC=WO&NR=2016118565A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GIGSTAD, KENNETH, M</creatorcontrib><creatorcontrib>LEE, HONG, MYUNG</creatorcontrib><creatorcontrib>VYSKOCIL, STEPAN</creatorcontrib><creatorcontrib>SHI, ZHAN</creatorcontrib><creatorcontrib>FREEZE, BRIAN, SCOTT</creatorcontrib><creatorcontrib>JANOWICK, DAVID, A</creatorcontrib><creatorcontrib>SOUCY, FRANCOIS</creatorcontrib><title>QUINAZOLINE AND QUINOLINE COMPOUNDS AND USES THEREOF</title><description>This invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein T, J, R, R4, Rq, o, RA, W and RB and subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions, and/or T-cell mediated autoimmune disease.
La présente invention concerne des composés de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci. Dans la formule (I), T, J, R, R4, Rq, o, RA, W et RB, et des sous-ensembles de ceux-ci sont tels que décrits dans la description. Lesdits composés sont des inhibiteurs de NAMPT et sont ainsi utiles pour le traitement du cancer, d'états inflammatoires et/ou d'une maladie auto-immune médies par des lymphocytes T.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAJDPX0c4zy9_H0c1Vw9HNRAPEhPGd_3wD_UD-XYLB4aLBrsEKIh2uQq78bDwNrWmJOcSovlOZmUHZzDXH20E0tyI9PLS5ITE7NSy2JD_c3MjA0MzS0MDUzdTQ0Jk4VAH0rKH8</recordid><startdate>20160728</startdate><enddate>20160728</enddate><creator>GIGSTAD, KENNETH, M</creator><creator>LEE, HONG, MYUNG</creator><creator>VYSKOCIL, STEPAN</creator><creator>SHI, ZHAN</creator><creator>FREEZE, BRIAN, SCOTT</creator><creator>JANOWICK, DAVID, A</creator><creator>SOUCY, FRANCOIS</creator><scope>EVB</scope></search><sort><creationdate>20160728</creationdate><title>QUINAZOLINE AND QUINOLINE COMPOUNDS AND USES THEREOF</title><author>GIGSTAD, KENNETH, M ; LEE, HONG, MYUNG ; VYSKOCIL, STEPAN ; SHI, ZHAN ; FREEZE, BRIAN, SCOTT ; JANOWICK, DAVID, A ; SOUCY, FRANCOIS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2016118565A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>GIGSTAD, KENNETH, M</creatorcontrib><creatorcontrib>LEE, HONG, MYUNG</creatorcontrib><creatorcontrib>VYSKOCIL, STEPAN</creatorcontrib><creatorcontrib>SHI, ZHAN</creatorcontrib><creatorcontrib>FREEZE, BRIAN, SCOTT</creatorcontrib><creatorcontrib>JANOWICK, DAVID, A</creatorcontrib><creatorcontrib>SOUCY, FRANCOIS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GIGSTAD, KENNETH, M</au><au>LEE, HONG, MYUNG</au><au>VYSKOCIL, STEPAN</au><au>SHI, ZHAN</au><au>FREEZE, BRIAN, SCOTT</au><au>JANOWICK, DAVID, A</au><au>SOUCY, FRANCOIS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>QUINAZOLINE AND QUINOLINE COMPOUNDS AND USES THEREOF</title><date>2016-07-28</date><risdate>2016</risdate><abstract>This invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein T, J, R, R4, Rq, o, RA, W and RB and subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions, and/or T-cell mediated autoimmune disease.
La présente invention concerne des composés de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci. Dans la formule (I), T, J, R, R4, Rq, o, RA, W et RB, et des sous-ensembles de ceux-ci sont tels que décrits dans la description. Lesdits composés sont des inhibiteurs de NAMPT et sont ainsi utiles pour le traitement du cancer, d'états inflammatoires et/ou d'une maladie auto-immune médies par des lymphocytes T.</abstract><oa>free_for_read</oa></addata></record> |
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| title | QUINAZOLINE AND QUINOLINE COMPOUNDS AND USES THEREOF |
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