CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF
The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprisi...
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| creator | BRUBAKER, William F |
| description | The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.
L'invention concerne des promédicaments de la créatine susceptibles de traverser les membranes, des compositions pharmaceutiques comprenant des promédicaments de la créatine susceptibles de traverser les membranes et des méthodes de traitement de maladies telles que l'ischémie, l'insuffisance cardiaque, les troubles neurodégénératifs et les maladies génétiques affectant le système de la créatine kinase, lesdites méthodes impliquant l'administration de promédicaments de la créatine ou de compositions pharmaceutiques en contenant. L'invention concerne également le traitement d'une maladie génétique affectant le système de la créatine kinase, telle que, par exemple, un trouble affectant le transport ou la synthèse de la créatine, ledit traitement impliquant l'administration de promédicaments de la créatine ou de compositions pharmaceutiques en contenant. |
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L'invention concerne des promédicaments de la créatine susceptibles de traverser les membranes, des compositions pharmaceutiques comprenant des promédicaments de la créatine susceptibles de traverser les membranes et des méthodes de traitement de maladies telles que l'ischémie, l'insuffisance cardiaque, les troubles neurodégénératifs et les maladies génétiques affectant le système de la créatine kinase, lesdites méthodes impliquant l'administration de promédicaments de la créatine ou de compositions pharmaceutiques en contenant. L'invention concerne également le traitement d'une maladie génétique affectant le système de la créatine kinase, telle que, par exemple, un trouble affectant le transport ou la synthèse de la créatine, ledit traitement impliquant l'administration de promédicaments de la créatine ou de compositions pharmaceutiques en contenant.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161013&DB=EPODOC&CC=WO&NR=2016106284A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20161013&DB=EPODOC&CC=WO&NR=2016106284A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRUBAKER, William F</creatorcontrib><title>CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF</title><description>The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.
L'invention concerne des promédicaments de la créatine susceptibles de traverser les membranes, des compositions pharmaceutiques comprenant des promédicaments de la créatine susceptibles de traverser les membranes et des méthodes de traitement de maladies telles que l'ischémie, l'insuffisance cardiaque, les troubles neurodégénératifs et les maladies génétiques affectant le système de la créatine kinase, lesdites méthodes impliquant l'administration de promédicaments de la créatine ou de compositions pharmaceutiques en contenant. L'invention concerne également le traitement d'une maladie génétique affectant le système de la créatine kinase, telle que, par exemple, un trouble affectant le transport ou la synthèse de la créatine, ledit traitement impliquant l'administration de promédicaments de la créatine ou de compositions pharmaceutiques en contenant.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLByDnJ1DPH0c1UICPJ3CQp1D9ZRcPb3DfAP9gzx9PcLVnD0c1HwdQ3x8HcJVvB3UwgNdlUI8XANcvV342FgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgaGZoYGZkYWJo7GxsSpAgBhbyn7</recordid><startdate>20161013</startdate><enddate>20161013</enddate><creator>BRUBAKER, William F</creator><scope>EVB</scope></search><sort><creationdate>20161013</creationdate><title>CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF</title><author>BRUBAKER, William F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2016106284A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BRUBAKER, William F</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BRUBAKER, William F</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF</title><date>2016-10-13</date><risdate>2016</risdate><abstract>The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.
L'invention concerne des promédicaments de la créatine susceptibles de traverser les membranes, des compositions pharmaceutiques comprenant des promédicaments de la créatine susceptibles de traverser les membranes et des méthodes de traitement de maladies telles que l'ischémie, l'insuffisance cardiaque, les troubles neurodégénératifs et les maladies génétiques affectant le système de la créatine kinase, lesdites méthodes impliquant l'administration de promédicaments de la créatine ou de compositions pharmaceutiques en contenant. L'invention concerne également le traitement d'une maladie génétique affectant le système de la créatine kinase, telle que, par exemple, un trouble affectant le transport ou la synthèse de la créatine, ledit traitement impliquant l'administration de promédicaments de la créatine ou de compositions pharmaceutiques en contenant.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF |
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