PREPARATION OF A HIGHLY PURE INTERMEDIATE FOR THE SYNTHESIS OF ODANACATIB
A process for producing (S)-2-(((S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-N- (1-cyanocyclopropyl)-4-fluoro-4-methylpentanamide of formula 1 by reaction of the acid or its salts of formula 3 with the compound of formula 4, the reaction being performed in a solvent in the presence of the n-pro...
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| creator | BABIAK, PETER ZEZULA, JOSEF |
| description | A process for producing (S)-2-(((S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-N- (1-cyanocyclopropyl)-4-fluoro-4-methylpentanamide of formula 1 by reaction of the acid or its salts of formula 3 with the compound of formula 4, the reaction being performed in a solvent in the presence of the n-propanephosphonic acid anhydride of formula 5 and a base.
La présente invention concerne un procédé de production de (S)-2-(((S)-1-(4-bromophényl)-2,2,2-trifluoroéthyl)amino)-N-(1-cyanocyclopropyl)-4-fluoro-4-méthylpentanamide de formule 1 par réaction de l'acide ou ses sels de formule 3 avec le composé de formule 4, la réaction étant effectuée dans un solvant en présence de l'anhydride de l'acide n-propanephosphonique de formule 5 et d'une base. |
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La présente invention concerne un procédé de production de (S)-2-(((S)-1-(4-bromophényl)-2,2,2-trifluoroéthyl)amino)-N-(1-cyanocyclopropyl)-4-fluoro-4-méthylpentanamide de formule 1 par réaction de l'acide ou ses sels de formule 3 avec le composé de formule 4, la réaction étant effectuée dans un solvant en présence de l'anhydride de l'acide n-propanephosphonique de formule 5 et d'une base.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160623&DB=EPODOC&CC=WO&NR=2016095879A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160623&DB=EPODOC&CC=WO&NR=2016095879A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BABIAK, PETER</creatorcontrib><creatorcontrib>ZEZULA, JOSEF</creatorcontrib><title>PREPARATION OF A HIGHLY PURE INTERMEDIATE FOR THE SYNTHESIS OF ODANACATIB</title><description>A process for producing (S)-2-(((S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-N- (1-cyanocyclopropyl)-4-fluoro-4-methylpentanamide of formula 1 by reaction of the acid or its salts of formula 3 with the compound of formula 4, the reaction being performed in a solvent in the presence of the n-propanephosphonic acid anhydride of formula 5 and a base.
La présente invention concerne un procédé de production de (S)-2-(((S)-1-(4-bromophényl)-2,2,2-trifluoroéthyl)amino)-N-(1-cyanocyclopropyl)-4-fluoro-4-méthylpentanamide de formule 1 par réaction de l'acide ou ses sels de formule 3 avec le composé de formule 4, la réaction étant effectuée dans un solvant en présence de l'anhydride de l'acide n-propanephosphonique de formule 5 et d'une base.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAMCHINcAxyDPH091Pwd1NwVPDwdPfwiVQICA1yVfD0C3EN8nV18XQMcVVw8w9SCPFwVQiO9ANSwZ7BIPX-Lo5-js5A7U48DKxpiTnFqbxQmptB2c01xNlDN7UgPz61uCAxOTUvtSQ-3N_IwNDMwNLUwtzS0dCYOFUA2HkuAg</recordid><startdate>20160623</startdate><enddate>20160623</enddate><creator>BABIAK, PETER</creator><creator>ZEZULA, JOSEF</creator><scope>EVB</scope></search><sort><creationdate>20160623</creationdate><title>PREPARATION OF A HIGHLY PURE INTERMEDIATE FOR THE SYNTHESIS OF ODANACATIB</title><author>BABIAK, PETER ; ZEZULA, JOSEF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2016095879A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2016</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>BABIAK, PETER</creatorcontrib><creatorcontrib>ZEZULA, JOSEF</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BABIAK, PETER</au><au>ZEZULA, JOSEF</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PREPARATION OF A HIGHLY PURE INTERMEDIATE FOR THE SYNTHESIS OF ODANACATIB</title><date>2016-06-23</date><risdate>2016</risdate><abstract>A process for producing (S)-2-(((S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-N- (1-cyanocyclopropyl)-4-fluoro-4-methylpentanamide of formula 1 by reaction of the acid or its salts of formula 3 with the compound of formula 4, the reaction being performed in a solvent in the presence of the n-propanephosphonic acid anhydride of formula 5 and a base.
La présente invention concerne un procédé de production de (S)-2-(((S)-1-(4-bromophényl)-2,2,2-trifluoroéthyl)amino)-N-(1-cyanocyclopropyl)-4-fluoro-4-méthylpentanamide de formule 1 par réaction de l'acide ou ses sels de formule 3 avec le composé de formule 4, la réaction étant effectuée dans un solvant en présence de l'anhydride de l'acide n-propanephosphonique de formule 5 et d'une base.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PREPARATION OF A HIGHLY PURE INTERMEDIATE FOR THE SYNTHESIS OF ODANACATIB |
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