LC36 GENE, RLC36 RECOMBINANT PROTEIN, USE THEREOF AND METHOD FOR DIAGNOSING LEISHMANIASES, PREFERABLY CANINE VISCERAL LEISHMANIASIS
The aim of the present invention is to characterize the L. chagasi Lc36 gene in terms of antigenic potential, for subsequent validation and use of the associated product, the rLc36 recombinant protein, in diagnostic tests for leishmaniases, preferably canine visceral leishmaniasis (CVL). Said protei...
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| creator | FERREIRA ISABEL, THAIS SILVA, FLÁVIO HENRIQUE DA TITA NOGUEIRA, CAMILA SILVA GRAMINHA, MÁRCIA APARECIDA DEL CISTIA, MAYARA LÚCIA COSTA, PAULO INÁCIO DA FERREIRA, HENRIQUE ZACARIAS MACHADO, ROSÂNGELA |
| description | The aim of the present invention is to characterize the L. chagasi Lc36 gene in terms of antigenic potential, for subsequent validation and use of the associated product, the rLc36 recombinant protein, in diagnostic tests for leishmaniases, preferably canine visceral leishmaniasis (CVL). Said protein can be used in the biotechnology sector as a component of diagnostic kits for detecting CVL IgG antibodies by means of immunoenzymatic assays. In addition to an ELISA, said assays can be performed by adsorption of the recombinant protein on other solid substrates and using various detection systems, including agglutination tests, immunochromatography, immunofluorescence, western blot, dot blot and biosensor. Said recombinant protein can also be used for producing vaccines. The present technology could be used in the composition of a novel diagnostic kit for CVL which is more sensitive and specific than currently available technologies.
La présente invention vise à caractériser le gène Lc36 de L. chagasi en termes de potentiel antigénique, en vue d'une validation postérieure et d'une application de son produit respectif, la protéine recombinante rLc36, dans un test diagnostique pour les leishmanioses, de préférence pour la leishmaniose viscérale canine (LVC). La protéine peut être utilisée dans l'industrie biotechnologique comme composant de trousses de diagnostic pour la détection d'anticorps de la classe IgG dans la LVC par essai immunoenzymatique. Outre ELISA, les essais peuvent être réalisés par adsorption de la protéine recombinante sur d'autres supports solides et avec différents systèmes de détection incluant le test d'agglutination, l'immunochromatographie, l'immunofluorescence, le transfert Western, le transfert en point et le biocapteur. La production de vaccins est également une application possible pour cette protéine recombinante. La présente technologie peut être utilisée dans la composition d'une nouvelle trousse de diagnostic pour la LVC, plus sensible et spécifique par comparaison avec les technologies actuellement disponibles.
A presente invenção tem por objetivo caracterizar o gene Lc36 de L. chagasi quanto ao potencial antigênico, para posterior validação e aplicação do seu respectivo produto, a proteína recombinante rLc36, em teste diagnóstico para leishmanioses, preferencialmente, para leishmaniose visceral canina(LVC). A proteína poderá ser empregada na indústria biotecnológica como componentes de kits diagnósticos para detecção de antico |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2016041040A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2016041040A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2016041040A13</originalsourceid><addsrcrecordid>eNqNi7EKwjAURbs4iPoPD1wrpFa6p-lL86B9kSQqTqVInEQL9Q_8cYs4ODrdw-HcefJqVF5AjYwpuA87VLYtiSUH2DsbkDiFg0cIBh1aDZIraDEYW4G2DiqSNVtPXEOD5E0rmaRHn05v1Ohk2ZxBTZIRjuTVZJrfkvwymV372xhX310ka41BmU0cHl0ch_4S7_HZnexWZIXYZWInZJb_V70BhaA9MQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>LC36 GENE, RLC36 RECOMBINANT PROTEIN, USE THEREOF AND METHOD FOR DIAGNOSING LEISHMANIASES, PREFERABLY CANINE VISCERAL LEISHMANIASIS</title><source>esp@cenet</source><creator>FERREIRA ISABEL, THAIS ; SILVA, FLÁVIO HENRIQUE DA ; TITA NOGUEIRA, CAMILA ; SILVA GRAMINHA, MÁRCIA APARECIDA ; DEL CISTIA, MAYARA LÚCIA ; COSTA, PAULO INÁCIO DA ; FERREIRA, HENRIQUE ; ZACARIAS MACHADO, ROSÂNGELA</creator><creatorcontrib>FERREIRA ISABEL, THAIS ; SILVA, FLÁVIO HENRIQUE DA ; TITA NOGUEIRA, CAMILA ; SILVA GRAMINHA, MÁRCIA APARECIDA ; DEL CISTIA, MAYARA LÚCIA ; COSTA, PAULO INÁCIO DA ; FERREIRA, HENRIQUE ; ZACARIAS MACHADO, ROSÂNGELA</creatorcontrib><description>The aim of the present invention is to characterize the L. chagasi Lc36 gene in terms of antigenic potential, for subsequent validation and use of the associated product, the rLc36 recombinant protein, in diagnostic tests for leishmaniases, preferably canine visceral leishmaniasis (CVL). Said protein can be used in the biotechnology sector as a component of diagnostic kits for detecting CVL IgG antibodies by means of immunoenzymatic assays. In addition to an ELISA, said assays can be performed by adsorption of the recombinant protein on other solid substrates and using various detection systems, including agglutination tests, immunochromatography, immunofluorescence, western blot, dot blot and biosensor. Said recombinant protein can also be used for producing vaccines. The present technology could be used in the composition of a novel diagnostic kit for CVL which is more sensitive and specific than currently available technologies.
La présente invention vise à caractériser le gène Lc36 de L. chagasi en termes de potentiel antigénique, en vue d'une validation postérieure et d'une application de son produit respectif, la protéine recombinante rLc36, dans un test diagnostique pour les leishmanioses, de préférence pour la leishmaniose viscérale canine (LVC). La protéine peut être utilisée dans l'industrie biotechnologique comme composant de trousses de diagnostic pour la détection d'anticorps de la classe IgG dans la LVC par essai immunoenzymatique. Outre ELISA, les essais peuvent être réalisés par adsorption de la protéine recombinante sur d'autres supports solides et avec différents systèmes de détection incluant le test d'agglutination, l'immunochromatographie, l'immunofluorescence, le transfert Western, le transfert en point et le biocapteur. La production de vaccins est également une application possible pour cette protéine recombinante. La présente technologie peut être utilisée dans la composition d'une nouvelle trousse de diagnostic pour la LVC, plus sensible et spécifique par comparaison avec les technologies actuellement disponibles.
A presente invenção tem por objetivo caracterizar o gene Lc36 de L. chagasi quanto ao potencial antigênico, para posterior validação e aplicação do seu respectivo produto, a proteína recombinante rLc36, em teste diagnóstico para leishmanioses, preferencialmente, para leishmaniose visceral canina(LVC). A proteína poderá ser empregada na indústria biotecnológica como componentes de kits diagnósticos para detecção de anticorpos da classe IgG na LVC através de ensaio imunoenzimático. Além do ELISA, os ensaios poderão ser realizados por adsorção da proteína recombinante em outros suportes sólidos e com diferentes sistemas de detecção incluindo teste de aglutinação, imunocromatografia, imunofluorescência, western blot, dot blot e biossensor. A produção de vacinas também poderá ser uma aplicação para esta proteína recombinante. A presente tecnologia poderá ser empregada na composição de um novo kit diagnóstico para LVC, mais sensível e específico do que as tecnologias atualmente disponíveis.</description><language>eng ; fre ; por</language><subject>CHEMISTRY ; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC ; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ; TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE ; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE ; TESTING</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160324&DB=EPODOC&CC=WO&NR=2016041040A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160324&DB=EPODOC&CC=WO&NR=2016041040A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FERREIRA ISABEL, THAIS</creatorcontrib><creatorcontrib>SILVA, FLÁVIO HENRIQUE DA</creatorcontrib><creatorcontrib>TITA NOGUEIRA, CAMILA</creatorcontrib><creatorcontrib>SILVA GRAMINHA, MÁRCIA APARECIDA</creatorcontrib><creatorcontrib>DEL CISTIA, MAYARA LÚCIA</creatorcontrib><creatorcontrib>COSTA, PAULO INÁCIO DA</creatorcontrib><creatorcontrib>FERREIRA, HENRIQUE</creatorcontrib><creatorcontrib>ZACARIAS MACHADO, ROSÂNGELA</creatorcontrib><title>LC36 GENE, RLC36 RECOMBINANT PROTEIN, USE THEREOF AND METHOD FOR DIAGNOSING LEISHMANIASES, PREFERABLY CANINE VISCERAL LEISHMANIASIS</title><description>The aim of the present invention is to characterize the L. chagasi Lc36 gene in terms of antigenic potential, for subsequent validation and use of the associated product, the rLc36 recombinant protein, in diagnostic tests for leishmaniases, preferably canine visceral leishmaniasis (CVL). Said protein can be used in the biotechnology sector as a component of diagnostic kits for detecting CVL IgG antibodies by means of immunoenzymatic assays. In addition to an ELISA, said assays can be performed by adsorption of the recombinant protein on other solid substrates and using various detection systems, including agglutination tests, immunochromatography, immunofluorescence, western blot, dot blot and biosensor. Said recombinant protein can also be used for producing vaccines. The present technology could be used in the composition of a novel diagnostic kit for CVL which is more sensitive and specific than currently available technologies.
La présente invention vise à caractériser le gène Lc36 de L. chagasi en termes de potentiel antigénique, en vue d'une validation postérieure et d'une application de son produit respectif, la protéine recombinante rLc36, dans un test diagnostique pour les leishmanioses, de préférence pour la leishmaniose viscérale canine (LVC). La protéine peut être utilisée dans l'industrie biotechnologique comme composant de trousses de diagnostic pour la détection d'anticorps de la classe IgG dans la LVC par essai immunoenzymatique. Outre ELISA, les essais peuvent être réalisés par adsorption de la protéine recombinante sur d'autres supports solides et avec différents systèmes de détection incluant le test d'agglutination, l'immunochromatographie, l'immunofluorescence, le transfert Western, le transfert en point et le biocapteur. La production de vaccins est également une application possible pour cette protéine recombinante. La présente technologie peut être utilisée dans la composition d'une nouvelle trousse de diagnostic pour la LVC, plus sensible et spécifique par comparaison avec les technologies actuellement disponibles.
A presente invenção tem por objetivo caracterizar o gene Lc36 de L. chagasi quanto ao potencial antigênico, para posterior validação e aplicação do seu respectivo produto, a proteína recombinante rLc36, em teste diagnóstico para leishmanioses, preferencialmente, para leishmaniose visceral canina(LVC). A proteína poderá ser empregada na indústria biotecnológica como componentes de kits diagnósticos para detecção de anticorpos da classe IgG na LVC através de ensaio imunoenzimático. Além do ELISA, os ensaios poderão ser realizados por adsorção da proteína recombinante em outros suportes sólidos e com diferentes sistemas de detecção incluindo teste de aglutinação, imunocromatografia, imunofluorescência, western blot, dot blot e biossensor. A produção de vacinas também poderá ser uma aplicação para esta proteína recombinante. A presente tecnologia poderá ser empregada na composição de um novo kit diagnóstico para LVC, mais sensível e específico do que as tecnologias atualmente disponíveis.</description><subject>CHEMISTRY</subject><subject>GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC</subject><subject>GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS</subject><subject>TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE</subject><subject>TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi7EKwjAURbs4iPoPD1wrpFa6p-lL86B9kSQqTqVInEQL9Q_8cYs4ODrdw-HcefJqVF5AjYwpuA87VLYtiSUH2DsbkDiFg0cIBh1aDZIraDEYW4G2DiqSNVtPXEOD5E0rmaRHn05v1Ohk2ZxBTZIRjuTVZJrfkvwymV372xhX310ka41BmU0cHl0ch_4S7_HZnexWZIXYZWInZJb_V70BhaA9MQ</recordid><startdate>20160324</startdate><enddate>20160324</enddate><creator>FERREIRA ISABEL, THAIS</creator><creator>SILVA, FLÁVIO HENRIQUE DA</creator><creator>TITA NOGUEIRA, CAMILA</creator><creator>SILVA GRAMINHA, MÁRCIA APARECIDA</creator><creator>DEL CISTIA, MAYARA LÚCIA</creator><creator>COSTA, PAULO INÁCIO DA</creator><creator>FERREIRA, HENRIQUE</creator><creator>ZACARIAS MACHADO, ROSÂNGELA</creator><scope>EVB</scope></search><sort><creationdate>20160324</creationdate><title>LC36 GENE, RLC36 RECOMBINANT PROTEIN, USE THEREOF AND METHOD FOR DIAGNOSING LEISHMANIASES, PREFERABLY CANINE VISCERAL LEISHMANIASIS</title><author>FERREIRA ISABEL, THAIS ; SILVA, FLÁVIO HENRIQUE DA ; TITA NOGUEIRA, CAMILA ; SILVA GRAMINHA, MÁRCIA APARECIDA ; DEL CISTIA, MAYARA LÚCIA ; COSTA, PAULO INÁCIO DA ; FERREIRA, HENRIQUE ; ZACARIAS MACHADO, ROSÂNGELA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2016041040A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; por</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC</topic><topic>GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS</topic><topic>TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE</topic><topic>TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>FERREIRA ISABEL, THAIS</creatorcontrib><creatorcontrib>SILVA, FLÁVIO HENRIQUE DA</creatorcontrib><creatorcontrib>TITA NOGUEIRA, CAMILA</creatorcontrib><creatorcontrib>SILVA GRAMINHA, MÁRCIA APARECIDA</creatorcontrib><creatorcontrib>DEL CISTIA, MAYARA LÚCIA</creatorcontrib><creatorcontrib>COSTA, PAULO INÁCIO DA</creatorcontrib><creatorcontrib>FERREIRA, HENRIQUE</creatorcontrib><creatorcontrib>ZACARIAS MACHADO, ROSÂNGELA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FERREIRA ISABEL, THAIS</au><au>SILVA, FLÁVIO HENRIQUE DA</au><au>TITA NOGUEIRA, CAMILA</au><au>SILVA GRAMINHA, MÁRCIA APARECIDA</au><au>DEL CISTIA, MAYARA LÚCIA</au><au>COSTA, PAULO INÁCIO DA</au><au>FERREIRA, HENRIQUE</au><au>ZACARIAS MACHADO, ROSÂNGELA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>LC36 GENE, RLC36 RECOMBINANT PROTEIN, USE THEREOF AND METHOD FOR DIAGNOSING LEISHMANIASES, PREFERABLY CANINE VISCERAL LEISHMANIASIS</title><date>2016-03-24</date><risdate>2016</risdate><abstract>The aim of the present invention is to characterize the L. chagasi Lc36 gene in terms of antigenic potential, for subsequent validation and use of the associated product, the rLc36 recombinant protein, in diagnostic tests for leishmaniases, preferably canine visceral leishmaniasis (CVL). Said protein can be used in the biotechnology sector as a component of diagnostic kits for detecting CVL IgG antibodies by means of immunoenzymatic assays. In addition to an ELISA, said assays can be performed by adsorption of the recombinant protein on other solid substrates and using various detection systems, including agglutination tests, immunochromatography, immunofluorescence, western blot, dot blot and biosensor. Said recombinant protein can also be used for producing vaccines. The present technology could be used in the composition of a novel diagnostic kit for CVL which is more sensitive and specific than currently available technologies.
La présente invention vise à caractériser le gène Lc36 de L. chagasi en termes de potentiel antigénique, en vue d'une validation postérieure et d'une application de son produit respectif, la protéine recombinante rLc36, dans un test diagnostique pour les leishmanioses, de préférence pour la leishmaniose viscérale canine (LVC). La protéine peut être utilisée dans l'industrie biotechnologique comme composant de trousses de diagnostic pour la détection d'anticorps de la classe IgG dans la LVC par essai immunoenzymatique. Outre ELISA, les essais peuvent être réalisés par adsorption de la protéine recombinante sur d'autres supports solides et avec différents systèmes de détection incluant le test d'agglutination, l'immunochromatographie, l'immunofluorescence, le transfert Western, le transfert en point et le biocapteur. La production de vaccins est également une application possible pour cette protéine recombinante. La présente technologie peut être utilisée dans la composition d'une nouvelle trousse de diagnostic pour la LVC, plus sensible et spécifique par comparaison avec les technologies actuellement disponibles.
A presente invenção tem por objetivo caracterizar o gene Lc36 de L. chagasi quanto ao potencial antigênico, para posterior validação e aplicação do seu respectivo produto, a proteína recombinante rLc36, em teste diagnóstico para leishmanioses, preferencialmente, para leishmaniose visceral canina(LVC). A proteína poderá ser empregada na indústria biotecnológica como componentes de kits diagnósticos para detecção de anticorpos da classe IgG na LVC através de ensaio imunoenzimático. Além do ELISA, os ensaios poderão ser realizados por adsorção da proteína recombinante em outros suportes sólidos e com diferentes sistemas de detecção incluindo teste de aglutinação, imunocromatografia, imunofluorescência, western blot, dot blot e biossensor. A produção de vacinas também poderá ser uma aplicação para esta proteína recombinante. A presente tecnologia poderá ser empregada na composição de um novo kit diagnóstico para LVC, mais sensível e específico do que as tecnologias atualmente disponíveis.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE TESTING |
| title | LC36 GENE, RLC36 RECOMBINANT PROTEIN, USE THEREOF AND METHOD FOR DIAGNOSING LEISHMANIASES, PREFERABLY CANINE VISCERAL LEISHMANIASIS |
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