MEANS AND METHODS FOR PREDICTING AN EXTRAMEDULLARY RELAPSE IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
The invention relates to the field of cancer diagnosis and therapy design, in particular diagnosis of extramedullary (EM) involvement in a subject afflicted with acute lymphoblastic leukemia. Provided is a method comprising determining in ALL cells the relative level and/or absolute amount of Stearo...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | VAN DONGEN, JACOBUS JOHANNES MARIA VAN DER VELDEN, VINCENT HENRICUS JOHANNES |
| description | The invention relates to the field of cancer diagnosis and therapy design, in particular diagnosis of extramedullary (EM) involvement in a subject afflicted with acute lymphoblastic leukemia. Provided is a method comprising determining in ALL cells the relative level and/or absolute amount of Stearoyl-Co A desaturase (SCD; EC 1.14.19.1) protein; and correlating the level and/or absolute amount of the SCD protein with the risk of developing an EM relapse, wherein an increased level and/or absolute amount of SCD relative to a control sample is indicative of having an increased risk of developing an extramedullary relapse. Also provided are reagent compositions and a diagnostic kit.
L'invention concerne le domaine du diagnostic et de la conception de thérapie du cancer, en particulier le diagnostic d'une atteinte extramédullaire (EM) chez un sujet atteint de leucémie lymphoblastique aiguë. L'invention concerne un procédé comprenant la détermination dans des cellules LLA du taux relatif et/ou de la quantité absolue de protéine stéaroyl-CoA désaturase (SCD ; EC 1.14.19.1) ; et la corrélation du taux et/ou de la quantité absolue de la protéine SCD au risque de développement d'une récidive EM, un taux et/ou une quantité absolue augmenté de SCD par rapport à un échantillon témoin étant indicatif de l'existence d'un risque accru de développer une récidive extramédullaire. L'invention concerne en outre des compositions de réactif et un kit de diagnostic. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2015190931A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2015190931A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2015190931A13</originalsourceid><addsrcrecordid>eNqNyrEKwjAQgOEuDqK-w4GLDkKjOHQ8k6sNXpKSpGinWiROooX6_ujgAzj9w_dPs6shtAHQKjAUK6cClM5D7UlpGbU9fgnoEj0aUg0z-hY8MdaBQFtA2UQCbk1duQNjiFoCU3MioxFWyLyeZ5N7_xjT4tdZtiwpymqThleXxqG_pWd6d2e3zcVeFHmxEyh2_10fKSU0CQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>MEANS AND METHODS FOR PREDICTING AN EXTRAMEDULLARY RELAPSE IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)</title><source>esp@cenet</source><creator>VAN DONGEN, JACOBUS JOHANNES MARIA ; VAN DER VELDEN, VINCENT HENRICUS JOHANNES</creator><creatorcontrib>VAN DONGEN, JACOBUS JOHANNES MARIA ; VAN DER VELDEN, VINCENT HENRICUS JOHANNES</creatorcontrib><description>The invention relates to the field of cancer diagnosis and therapy design, in particular diagnosis of extramedullary (EM) involvement in a subject afflicted with acute lymphoblastic leukemia. Provided is a method comprising determining in ALL cells the relative level and/or absolute amount of Stearoyl-Co A desaturase (SCD; EC 1.14.19.1) protein; and correlating the level and/or absolute amount of the SCD protein with the risk of developing an EM relapse, wherein an increased level and/or absolute amount of SCD relative to a control sample is indicative of having an increased risk of developing an extramedullary relapse. Also provided are reagent compositions and a diagnostic kit.
L'invention concerne le domaine du diagnostic et de la conception de thérapie du cancer, en particulier le diagnostic d'une atteinte extramédullaire (EM) chez un sujet atteint de leucémie lymphoblastique aiguë. L'invention concerne un procédé comprenant la détermination dans des cellules LLA du taux relatif et/ou de la quantité absolue de protéine stéaroyl-CoA désaturase (SCD ; EC 1.14.19.1) ; et la corrélation du taux et/ou de la quantité absolue de la protéine SCD au risque de développement d'une récidive EM, un taux et/ou une quantité absolue augmenté de SCD par rapport à un échantillon témoin étant indicatif de l'existence d'un risque accru de développer une récidive extramédullaire. L'invention concerne en outre des compositions de réactif et un kit de diagnostic.</description><language>eng ; fre</language><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; PHYSICS ; TESTING</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151217&DB=EPODOC&CC=WO&NR=2015190931A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151217&DB=EPODOC&CC=WO&NR=2015190931A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VAN DONGEN, JACOBUS JOHANNES MARIA</creatorcontrib><creatorcontrib>VAN DER VELDEN, VINCENT HENRICUS JOHANNES</creatorcontrib><title>MEANS AND METHODS FOR PREDICTING AN EXTRAMEDULLARY RELAPSE IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)</title><description>The invention relates to the field of cancer diagnosis and therapy design, in particular diagnosis of extramedullary (EM) involvement in a subject afflicted with acute lymphoblastic leukemia. Provided is a method comprising determining in ALL cells the relative level and/or absolute amount of Stearoyl-Co A desaturase (SCD; EC 1.14.19.1) protein; and correlating the level and/or absolute amount of the SCD protein with the risk of developing an EM relapse, wherein an increased level and/or absolute amount of SCD relative to a control sample is indicative of having an increased risk of developing an extramedullary relapse. Also provided are reagent compositions and a diagnostic kit.
L'invention concerne le domaine du diagnostic et de la conception de thérapie du cancer, en particulier le diagnostic d'une atteinte extramédullaire (EM) chez un sujet atteint de leucémie lymphoblastique aiguë. L'invention concerne un procédé comprenant la détermination dans des cellules LLA du taux relatif et/ou de la quantité absolue de protéine stéaroyl-CoA désaturase (SCD ; EC 1.14.19.1) ; et la corrélation du taux et/ou de la quantité absolue de la protéine SCD au risque de développement d'une récidive EM, un taux et/ou une quantité absolue augmenté de SCD par rapport à un échantillon témoin étant indicatif de l'existence d'un risque accru de développer une récidive extramédullaire. L'invention concerne en outre des compositions de réactif et un kit de diagnostic.</description><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>PHYSICS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQgOEuDqK-w4GLDkKjOHQ8k6sNXpKSpGinWiROooX6_ujgAzj9w_dPs6shtAHQKjAUK6cClM5D7UlpGbU9fgnoEj0aUg0z-hY8MdaBQFtA2UQCbk1duQNjiFoCU3MioxFWyLyeZ5N7_xjT4tdZtiwpymqThleXxqG_pWd6d2e3zcVeFHmxEyh2_10fKSU0CQ</recordid><startdate>20151217</startdate><enddate>20151217</enddate><creator>VAN DONGEN, JACOBUS JOHANNES MARIA</creator><creator>VAN DER VELDEN, VINCENT HENRICUS JOHANNES</creator><scope>EVB</scope></search><sort><creationdate>20151217</creationdate><title>MEANS AND METHODS FOR PREDICTING AN EXTRAMEDULLARY RELAPSE IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)</title><author>VAN DONGEN, JACOBUS JOHANNES MARIA ; VAN DER VELDEN, VINCENT HENRICUS JOHANNES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2015190931A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2015</creationdate><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>PHYSICS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>VAN DONGEN, JACOBUS JOHANNES MARIA</creatorcontrib><creatorcontrib>VAN DER VELDEN, VINCENT HENRICUS JOHANNES</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VAN DONGEN, JACOBUS JOHANNES MARIA</au><au>VAN DER VELDEN, VINCENT HENRICUS JOHANNES</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MEANS AND METHODS FOR PREDICTING AN EXTRAMEDULLARY RELAPSE IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)</title><date>2015-12-17</date><risdate>2015</risdate><abstract>The invention relates to the field of cancer diagnosis and therapy design, in particular diagnosis of extramedullary (EM) involvement in a subject afflicted with acute lymphoblastic leukemia. Provided is a method comprising determining in ALL cells the relative level and/or absolute amount of Stearoyl-Co A desaturase (SCD; EC 1.14.19.1) protein; and correlating the level and/or absolute amount of the SCD protein with the risk of developing an EM relapse, wherein an increased level and/or absolute amount of SCD relative to a control sample is indicative of having an increased risk of developing an extramedullary relapse. Also provided are reagent compositions and a diagnostic kit.
L'invention concerne le domaine du diagnostic et de la conception de thérapie du cancer, en particulier le diagnostic d'une atteinte extramédullaire (EM) chez un sujet atteint de leucémie lymphoblastique aiguë. L'invention concerne un procédé comprenant la détermination dans des cellules LLA du taux relatif et/ou de la quantité absolue de protéine stéaroyl-CoA désaturase (SCD ; EC 1.14.19.1) ; et la corrélation du taux et/ou de la quantité absolue de la protéine SCD au risque de développement d'une récidive EM, un taux et/ou une quantité absolue augmenté de SCD par rapport à un échantillon témoin étant indicatif de l'existence d'un risque accru de développer une récidive extramédullaire. L'invention concerne en outre des compositions de réactif et un kit de diagnostic.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2015190931A1 |
| source | esp@cenet |
| subjects | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING |
| title | MEANS AND METHODS FOR PREDICTING AN EXTRAMEDULLARY RELAPSE IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T15%3A56%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=VAN%20DONGEN,%20JACOBUS%20JOHANNES%20MARIA&rft.date=2015-12-17&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2015190931A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |