METHOD FOR PRODUCING RETINAL GANGLION CELLS FROM PLURIPOTENT CELLS
A method of making retinal ganglion cells, comprises the steps of: (a) differentiating pluripotent stem cells into retinal progenitor cells; and, (b) differentiating retinal progenitor cells into retinal ganglion cells. In another aspect, the present description provides a method of making retinal g...
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| creator | OHLEMACHER, SARAH K MEYER, JASON S |
| description | A method of making retinal ganglion cells, comprises the steps of: (a) differentiating pluripotent stem cells into retinal progenitor cells; and, (b) differentiating retinal progenitor cells into retinal ganglion cells. In another aspect, the present description provides a method of making retinal ganglion cells, comprising the steps of: (a) differentiating human pluripotent stem cells into retinal progenitor cells, the retinal progenitor cells expressing one or more of Chx10 and Pax6 and lacking Sox1 expression; and (b) differentiating retinal progenitor cells into retinal ganglion cells, the retinal ganglion cells having one or more of: retinal ganglion cell morphology; ability to fire action potentials; ability to exhibit inward sodium currents that are sensitive to a voltage-gated sodium channel blocker; ability to conduct potassium through voltage-gated channels; and Bm3 expression.
Un procédé de fabrication de cellules ganglionnaires de la rétine, comprend les étapes consistant à : (a) différencier les cellules souches pluripotentes en cellules progénitrices rétiniennes ; et, (b) différencier les cellules progénitrices rétiniennes en cellules ganglionnaires de la rétine. |
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Un procédé de fabrication de cellules ganglionnaires de la rétine, comprend les étapes consistant à : (a) différencier les cellules souches pluripotentes en cellules progénitrices rétiniennes ; et, (b) différencier les cellules progénitrices rétiniennes en cellules ganglionnaires de la rétine.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160317&DB=EPODOC&CC=WO&NR=2015171663A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160317&DB=EPODOC&CC=WO&NR=2015171663A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OHLEMACHER, SARAH K</creatorcontrib><creatorcontrib>MEYER, JASON S</creatorcontrib><title>METHOD FOR PRODUCING RETINAL GANGLION CELLS FROM PLURIPOTENT CELLS</title><description>A method of making retinal ganglion cells, comprises the steps of: (a) differentiating pluripotent stem cells into retinal progenitor cells; and, (b) differentiating retinal progenitor cells into retinal ganglion cells. In another aspect, the present description provides a method of making retinal ganglion cells, comprising the steps of: (a) differentiating human pluripotent stem cells into retinal progenitor cells, the retinal progenitor cells expressing one or more of Chx10 and Pax6 and lacking Sox1 expression; and (b) differentiating retinal progenitor cells into retinal ganglion cells, the retinal ganglion cells having one or more of: retinal ganglion cell morphology; ability to fire action potentials; ability to exhibit inward sodium currents that are sensitive to a voltage-gated sodium channel blocker; ability to conduct potassium through voltage-gated channels; and Bm3 expression.
Un procédé de fabrication de cellules ganglionnaires de la rétine, comprend les étapes consistant à : (a) différencier les cellules souches pluripotentes en cellules progénitrices rétiniennes ; et, (b) différencier les cellules progénitrices rétiniennes en cellules ganglionnaires de la rétine.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHDydQ3x8HdRcPMPUggI8ncJdfb0c1cIcg3x9HP0UXB39HP38fT3U3B29fEJVnAL8vdVCPAJDfIM8A9x9QuBCPMwsKYl5hSn8kJpbgZlN9cQZw_d1IL8-NTigsTk1LzUkvhwfyMDQ1NDc0MzM2NHY2PiVAEAvowsTg</recordid><startdate>20160317</startdate><enddate>20160317</enddate><creator>OHLEMACHER, SARAH K</creator><creator>MEYER, JASON S</creator><scope>EVB</scope></search><sort><creationdate>20160317</creationdate><title>METHOD FOR PRODUCING RETINAL GANGLION CELLS FROM PLURIPOTENT CELLS</title><author>OHLEMACHER, SARAH K ; MEYER, JASON S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2015171663A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2016</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>OHLEMACHER, SARAH K</creatorcontrib><creatorcontrib>MEYER, JASON S</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OHLEMACHER, SARAH K</au><au>MEYER, JASON S</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR PRODUCING RETINAL GANGLION CELLS FROM PLURIPOTENT CELLS</title><date>2016-03-17</date><risdate>2016</risdate><abstract>A method of making retinal ganglion cells, comprises the steps of: (a) differentiating pluripotent stem cells into retinal progenitor cells; and, (b) differentiating retinal progenitor cells into retinal ganglion cells. In another aspect, the present description provides a method of making retinal ganglion cells, comprising the steps of: (a) differentiating human pluripotent stem cells into retinal progenitor cells, the retinal progenitor cells expressing one or more of Chx10 and Pax6 and lacking Sox1 expression; and (b) differentiating retinal progenitor cells into retinal ganglion cells, the retinal ganglion cells having one or more of: retinal ganglion cell morphology; ability to fire action potentials; ability to exhibit inward sodium currents that are sensitive to a voltage-gated sodium channel blocker; ability to conduct potassium through voltage-gated channels; and Bm3 expression.
Un procédé de fabrication de cellules ganglionnaires de la rétine, comprend les étapes consistant à : (a) différencier les cellules souches pluripotentes en cellules progénitrices rétiniennes ; et, (b) différencier les cellules progénitrices rétiniennes en cellules ganglionnaires de la rétine.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | METHOD FOR PRODUCING RETINAL GANGLION CELLS FROM PLURIPOTENT CELLS |
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