AN IMPROVED PROCESS FOR THE SYNTHESIS OF DIMETHYL FUMARATE

AN IMPROVED PROCESS FOR THE SYNTHESIS OF DIMETHYL FUMARATE

The present invention describes an improved process for the industrial scale production of dimethyl fumarate. The process involves a one-pot ring opening reaction of maleic anhydride to monomethyl maleate and isomerization into the corresponding monomethyl fumarate in presence of a Lewis acid. Final...

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Hauptverfasser: PULLAGURLA, MANIK REDDY, RANGISETTY, JAGADEESH BABU, NANDAKUMAR, MECHERIL VALSAN, RADHA, NAGARAPU
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creator PULLAGURLA, MANIK REDDY
RANGISETTY, JAGADEESH BABU
NANDAKUMAR, MECHERIL VALSAN
RADHA, NAGARAPU
description The present invention describes an improved process for the industrial scale production of dimethyl fumarate. The process involves a one-pot ring opening reaction of maleic anhydride to monomethyl maleate and isomerization into the corresponding monomethyl fumarate in presence of a Lewis acid. Finally the mono methyl fumarate was converted into the dimethyl fumarate by an acid catalyzed esterification reaction. La présente invention concerne un procédé amélioré pour la production à l'échelle industrielle de diméthylfumarate. Le procédé comprend une réaction d'ouverture de cycle monotope d'anhydride maléique en monométhylmaléate et une isomérisation en monométhylfumarate correspondant, en présence d'un acide de Lewis. Enfin, le monométhylfumarate est transformé en diméthylfumarate par une réaction d'estérification catalysée par un acide.
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