FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY
The present invention provides a compound that has an autotaxin inhibitory effect and is represented by formula (I) (in the formula, R1, R2, R3, R4a, R4b, R5a, and R5b are as defined in the description.), a medicine that uses said compound as an active component, and a treatment or prevention method...
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| creator | ODAN, MASAHIDE YAMANE, JUNJI KOJIMA, HIROTATSU FUJIKOSHI, CHIAKI NAGANO, TETSUO OKABE, TAKAYOSHI AOKI, JUNKEN KAWAGUCHI, MITSUYASU ISHITANI, RYUICHIRO TATENO, YUSUKE NISHIMASU, HIROSHI NUREKI, OSAMU KATOU, MANABU TANAKA, NOBUYUKI |
| description | The present invention provides a compound that has an autotaxin inhibitory effect and is represented by formula (I) (in the formula, R1, R2, R3, R4a, R4b, R5a, and R5b are as defined in the description.), a medicine that uses said compound as an active component, and a treatment or prevention method for a disease involving autotaxin, said treatment or prevention method being characterized by the administration of said compound.
La présente invention concerne un composé qui a un effet inhibiteur d'autotaxine et est représenté par la formule (I) (dans la formule, R1, R2, R3, R4a, R4b, R5a, et R5b sont tels que définis dans la description), un médicament qui utilise ledit composé en tant que principe actif, et un procédé de traitement ou de prévention d'une maladie impliquant l'autotaxine, ledit procédé de traitement ou de prévention étant caractérisé par l'administration dudit composé.
本発明は、オートタキシン阻害作用を有する、式（Ｉ）（式中、Ｒ１、Ｒ２、Ｒ３、Ｒ４ａ、Ｒ４ｂ、Ｒ５ａおよびＲ５ｂは、明細書で定義した通りである。）で示される化合物、該化合物を有効成分とする医薬、および該化合物を投与することを特徴とする、オートタキシンが関与する疾患の治療または予防方法を提供する。 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2015129821A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2015129821A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2015129821A13</originalsourceid><addsrcrecordid>eNrjZLBzCw12dVEIiAxyjPL3cVVwcQ3yDHMM8QxzVfBwDPP0c1dwDA3xD3GM8PRT8PTz8HTyDPEPilRwdAYq8QyJ5GFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgaGpoZGlhZGho6GxsSpAgBEKiub</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY</title><source>esp@cenet</source><creator>ODAN, MASAHIDE ; YAMANE, JUNJI ; KOJIMA, HIROTATSU ; FUJIKOSHI, CHIAKI ; NAGANO, TETSUO ; OKABE, TAKAYOSHI ; AOKI, JUNKEN ; KAWAGUCHI, MITSUYASU ; ISHITANI, RYUICHIRO ; TATENO, YUSUKE ; NISHIMASU, HIROSHI ; NUREKI, OSAMU ; KATOU, MANABU ; TANAKA, NOBUYUKI</creator><creatorcontrib>ODAN, MASAHIDE ; YAMANE, JUNJI ; KOJIMA, HIROTATSU ; FUJIKOSHI, CHIAKI ; NAGANO, TETSUO ; OKABE, TAKAYOSHI ; AOKI, JUNKEN ; KAWAGUCHI, MITSUYASU ; ISHITANI, RYUICHIRO ; TATENO, YUSUKE ; NISHIMASU, HIROSHI ; NUREKI, OSAMU ; KATOU, MANABU ; TANAKA, NOBUYUKI</creatorcontrib><description>The present invention provides a compound that has an autotaxin inhibitory effect and is represented by formula (I) (in the formula, R1, R2, R3, R4a, R4b, R5a, and R5b are as defined in the description.), a medicine that uses said compound as an active component, and a treatment or prevention method for a disease involving autotaxin, said treatment or prevention method being characterized by the administration of said compound.
La présente invention concerne un composé qui a un effet inhibiteur d'autotaxine et est représenté par la formule (I) (dans la formule, R1, R2, R3, R4a, R4b, R5a, et R5b sont tels que définis dans la description), un médicament qui utilise ledit composé en tant que principe actif, et un procédé de traitement ou de prévention d'une maladie impliquant l'autotaxine, ledit procédé de traitement ou de prévention étant caractérisé par l'administration dudit composé.
本発明は、オートタキシン阻害作用を有する、式（Ｉ）（式中、Ｒ１、Ｒ２、Ｒ３、Ｒ４ａ、Ｒ４ｂ、Ｒ５ａおよびＲ５ｂは、明細書で定義した通りである。）で示される化合物、該化合物を有効成分とする医薬、および該化合物を投与することを特徴とする、オートタキシンが関与する疾患の治療または予防方法を提供する。</description><language>eng ; fre ; jpn</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150903&DB=EPODOC&CC=WO&NR=2015129821A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150903&DB=EPODOC&CC=WO&NR=2015129821A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ODAN, MASAHIDE</creatorcontrib><creatorcontrib>YAMANE, JUNJI</creatorcontrib><creatorcontrib>KOJIMA, HIROTATSU</creatorcontrib><creatorcontrib>FUJIKOSHI, CHIAKI</creatorcontrib><creatorcontrib>NAGANO, TETSUO</creatorcontrib><creatorcontrib>OKABE, TAKAYOSHI</creatorcontrib><creatorcontrib>AOKI, JUNKEN</creatorcontrib><creatorcontrib>KAWAGUCHI, MITSUYASU</creatorcontrib><creatorcontrib>ISHITANI, RYUICHIRO</creatorcontrib><creatorcontrib>TATENO, YUSUKE</creatorcontrib><creatorcontrib>NISHIMASU, HIROSHI</creatorcontrib><creatorcontrib>NUREKI, OSAMU</creatorcontrib><creatorcontrib>KATOU, MANABU</creatorcontrib><creatorcontrib>TANAKA, NOBUYUKI</creatorcontrib><title>FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY</title><description>The present invention provides a compound that has an autotaxin inhibitory effect and is represented by formula (I) (in the formula, R1, R2, R3, R4a, R4b, R5a, and R5b are as defined in the description.), a medicine that uses said compound as an active component, and a treatment or prevention method for a disease involving autotaxin, said treatment or prevention method being characterized by the administration of said compound.
La présente invention concerne un composé qui a un effet inhibiteur d'autotaxine et est représenté par la formule (I) (dans la formule, R1, R2, R3, R4a, R4b, R5a, et R5b sont tels que définis dans la description), un médicament qui utilise ledit composé en tant que principe actif, et un procédé de traitement ou de prévention d'une maladie impliquant l'autotaxine, ledit procédé de traitement ou de prévention étant caractérisé par l'administration dudit composé.
本発明は、オートタキシン阻害作用を有する、式（Ｉ）（式中、Ｒ１、Ｒ２、Ｒ３、Ｒ４ａ、Ｒ４ｂ、Ｒ５ａおよびＲ５ｂは、明細書で定義した通りである。）で示される化合物、該化合物を有効成分とする医薬、および該化合物を投与することを特徴とする、オートタキシンが関与する疾患の治療または予防方法を提供する。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBzCw12dVEIiAxyjPL3cVVwcQ3yDHMM8QxzVfBwDPP0c1dwDA3xD3GM8PRT8PTz8HTyDPEPilRwdAYq8QyJ5GFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgaGpoZGlhZGho6GxsSpAgBEKiub</recordid><startdate>20150903</startdate><enddate>20150903</enddate><creator>ODAN, MASAHIDE</creator><creator>YAMANE, JUNJI</creator><creator>KOJIMA, HIROTATSU</creator><creator>FUJIKOSHI, CHIAKI</creator><creator>NAGANO, TETSUO</creator><creator>OKABE, TAKAYOSHI</creator><creator>AOKI, JUNKEN</creator><creator>KAWAGUCHI, MITSUYASU</creator><creator>ISHITANI, RYUICHIRO</creator><creator>TATENO, YUSUKE</creator><creator>NISHIMASU, HIROSHI</creator><creator>NUREKI, OSAMU</creator><creator>KATOU, MANABU</creator><creator>TANAKA, NOBUYUKI</creator><scope>EVB</scope></search><sort><creationdate>20150903</creationdate><title>FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY</title><author>ODAN, MASAHIDE ; YAMANE, JUNJI ; KOJIMA, HIROTATSU ; FUJIKOSHI, CHIAKI ; NAGANO, TETSUO ; OKABE, TAKAYOSHI ; AOKI, JUNKEN ; KAWAGUCHI, MITSUYASU ; ISHITANI, RYUICHIRO ; TATENO, YUSUKE ; NISHIMASU, HIROSHI ; NUREKI, OSAMU ; KATOU, MANABU ; TANAKA, NOBUYUKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2015129821A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; jpn</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ODAN, MASAHIDE</creatorcontrib><creatorcontrib>YAMANE, JUNJI</creatorcontrib><creatorcontrib>KOJIMA, HIROTATSU</creatorcontrib><creatorcontrib>FUJIKOSHI, CHIAKI</creatorcontrib><creatorcontrib>NAGANO, TETSUO</creatorcontrib><creatorcontrib>OKABE, TAKAYOSHI</creatorcontrib><creatorcontrib>AOKI, JUNKEN</creatorcontrib><creatorcontrib>KAWAGUCHI, MITSUYASU</creatorcontrib><creatorcontrib>ISHITANI, RYUICHIRO</creatorcontrib><creatorcontrib>TATENO, YUSUKE</creatorcontrib><creatorcontrib>NISHIMASU, HIROSHI</creatorcontrib><creatorcontrib>NUREKI, OSAMU</creatorcontrib><creatorcontrib>KATOU, MANABU</creatorcontrib><creatorcontrib>TANAKA, NOBUYUKI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ODAN, MASAHIDE</au><au>YAMANE, JUNJI</au><au>KOJIMA, HIROTATSU</au><au>FUJIKOSHI, CHIAKI</au><au>NAGANO, TETSUO</au><au>OKABE, TAKAYOSHI</au><au>AOKI, JUNKEN</au><au>KAWAGUCHI, MITSUYASU</au><au>ISHITANI, RYUICHIRO</au><au>TATENO, YUSUKE</au><au>NISHIMASU, HIROSHI</au><au>NUREKI, OSAMU</au><au>KATOU, MANABU</au><au>TANAKA, NOBUYUKI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY</title><date>2015-09-03</date><risdate>2015</risdate><abstract>The present invention provides a compound that has an autotaxin inhibitory effect and is represented by formula (I) (in the formula, R1, R2, R3, R4a, R4b, R5a, and R5b are as defined in the description.), a medicine that uses said compound as an active component, and a treatment or prevention method for a disease involving autotaxin, said treatment or prevention method being characterized by the administration of said compound.
La présente invention concerne un composé qui a un effet inhibiteur d'autotaxine et est représenté par la formule (I) (dans la formule, R1, R2, R3, R4a, R4b, R5a, et R5b sont tels que définis dans la description), un médicament qui utilise ledit composé en tant que principe actif, et un procédé de traitement ou de prévention d'une maladie impliquant l'autotaxine, ledit procédé de traitement ou de prévention étant caractérisé par l'administration dudit composé.
本発明は、オートタキシン阻害作用を有する、式（Ｉ）（式中、Ｒ１、Ｒ２、Ｒ３、Ｒ４ａ、Ｒ４ｂ、Ｒ５ａおよびＲ５ｂは、明細書で定義した通りである。）で示される化合物、該化合物を有効成分とする医薬、および該化合物を投与することを特徴とする、オートタキシンが関与する疾患の治療または予防方法を提供する。</abstract><oa>free_for_read</oa></addata></record> |
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| title | FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY |
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