ANTI-TISSUE INHIBITOR OF METALLOPROTEINASE-4 (TIMP-4) ANTIBODIES AND METHODS OF USE THEREOF
Compositions and methods for treating diseases and disorders expressing tissue inhibitor of metalloproteinase-4 (TIMP-4) are provided. In accordance with the present invention, novel antibody molecules and fragments thereof immunologically specific for TIMP-4 are provided. In a particular embodiment...
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| creator | PRENDERGAST, GEORGE, C WALLON, U., MARGARETHA |
| description | Compositions and methods for treating diseases and disorders expressing tissue inhibitor of metalloproteinase-4 (TIMP-4) are provided. In accordance with the present invention, novel antibody molecules and fragments thereof immunologically specific for TIMP-4 are provided. In a particular embodiment, the disease or disorder is cancer, particularly breast, brain, ovarian, and/or esophageal cancer, or osteoarthritis, or cardiovascular disease. In a particular embodiment, the cancer over-expresses TIMP-4 and/or has aberrant TIMP-4 activity/function, e.g., overactivity. The methods comprise administering a therapeutically effective amount of the anti-TIMP-4 antibodies of the invention to a subject, e.g.,' as part of a pharmaceutical preparation.
La présente invention concerne des compositions et des procédés permettant de traiter des maladies et des troubles exprimant un inhibiteur tissulaire de la métalooprotéinase-4 (TIMP-4). La présente invention concerne de nouvelles molécules anticorps et leurs fragments immunologiquement spécifiques pour la TIMP-4. Dans un mode de réalisation particulier, la maladie ou le trouble est un cancer, particulièrement un cancer du sein, du cerveau, de l'ovaire et/ou de l'œsophage, ou une arthrose ou une maladie cardiovasculaire. Dans un mode de réalisation particulier, le cancer sur-exprime TIMP-4 et/ou présente une activité/fonction TIMP-4 aberrante, par ex. une suractivité. Les procédés consistent à administrer une quantité thérapeutiquement efficace des anticorps anti-TIMP-4 de l'invention à un sujet, par ex. sous forme d'une préparation pharmaceutique. |
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La présente invention concerne des compositions et des procédés permettant de traiter des maladies et des troubles exprimant un inhibiteur tissulaire de la métalooprotéinase-4 (TIMP-4). La présente invention concerne de nouvelles molécules anticorps et leurs fragments immunologiquement spécifiques pour la TIMP-4. Dans un mode de réalisation particulier, la maladie ou le trouble est un cancer, particulièrement un cancer du sein, du cerveau, de l'ovaire et/ou de l'œsophage, ou une arthrose ou une maladie cardiovasculaire. Dans un mode de réalisation particulier, le cancer sur-exprime TIMP-4 et/ou présente une activité/fonction TIMP-4 aberrante, par ex. une suractivité. Les procédés consistent à administrer une quantité thérapeutiquement efficace des anticorps anti-TIMP-4 de l'invention à un sujet, par ex. sous forme d'une préparation pharmaceutique.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; TESTING</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150806&DB=EPODOC&CC=WO&NR=2015116689A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150806&DB=EPODOC&CC=WO&NR=2015116689A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PRENDERGAST, GEORGE, C</creatorcontrib><creatorcontrib>WALLON, U., MARGARETHA</creatorcontrib><title>ANTI-TISSUE INHIBITOR OF METALLOPROTEINASE-4 (TIMP-4) ANTIBODIES AND METHODS OF USE THEREOF</title><description>Compositions and methods for treating diseases and disorders expressing tissue inhibitor of metalloproteinase-4 (TIMP-4) are provided. In accordance with the present invention, novel antibody molecules and fragments thereof immunologically specific for TIMP-4 are provided. In a particular embodiment, the disease or disorder is cancer, particularly breast, brain, ovarian, and/or esophageal cancer, or osteoarthritis, or cardiovascular disease. In a particular embodiment, the cancer over-expresses TIMP-4 and/or has aberrant TIMP-4 activity/function, e.g., overactivity. The methods comprise administering a therapeutically effective amount of the anti-TIMP-4 antibodies of the invention to a subject, e.g.,' as part of a pharmaceutical preparation.
La présente invention concerne des compositions et des procédés permettant de traiter des maladies et des troubles exprimant un inhibiteur tissulaire de la métalooprotéinase-4 (TIMP-4). La présente invention concerne de nouvelles molécules anticorps et leurs fragments immunologiquement spécifiques pour la TIMP-4. Dans un mode de réalisation particulier, la maladie ou le trouble est un cancer, particulièrement un cancer du sein, du cerveau, de l'ovaire et/ou de l'œsophage, ou une arthrose ou une maladie cardiovasculaire. Dans un mode de réalisation particulier, le cancer sur-exprime TIMP-4 et/ou présente une activité/fonction TIMP-4 aberrante, par ex. une suractivité. Les procédés consistent à administrer une quantité thérapeutiquement efficace des anticorps anti-TIMP-4 de l'invention à un sujet, par ex. sous forme d'une préparation pharmaceutique.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIh29Avx1A3xDA4OdVXw9PPwdPIM8Q9S8HdT8HUNcfTx8Q8I8g9x9fRzDHbVNVHQCPH0DdA10VQA6XLyd_F0DQYyXUBqPfxdgkHaQoNdFUI8XINc_d14GFjTEnOKU3mhNDeDsptriLOHbmpBfnxqcUFicmpeakl8uL-RgaGpoaGZmYWlo6ExcaoAIzkyoA</recordid><startdate>20150806</startdate><enddate>20150806</enddate><creator>PRENDERGAST, GEORGE, C</creator><creator>WALLON, U., MARGARETHA</creator><scope>EVB</scope></search><sort><creationdate>20150806</creationdate><title>ANTI-TISSUE INHIBITOR OF METALLOPROTEINASE-4 (TIMP-4) ANTIBODIES AND METHODS OF USE THEREOF</title><author>PRENDERGAST, GEORGE, C ; WALLON, U., MARGARETHA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2015116689A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>PRENDERGAST, GEORGE, C</creatorcontrib><creatorcontrib>WALLON, U., MARGARETHA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PRENDERGAST, GEORGE, C</au><au>WALLON, U., MARGARETHA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTI-TISSUE INHIBITOR OF METALLOPROTEINASE-4 (TIMP-4) ANTIBODIES AND METHODS OF USE THEREOF</title><date>2015-08-06</date><risdate>2015</risdate><abstract>Compositions and methods for treating diseases and disorders expressing tissue inhibitor of metalloproteinase-4 (TIMP-4) are provided. In accordance with the present invention, novel antibody molecules and fragments thereof immunologically specific for TIMP-4 are provided. In a particular embodiment, the disease or disorder is cancer, particularly breast, brain, ovarian, and/or esophageal cancer, or osteoarthritis, or cardiovascular disease. In a particular embodiment, the cancer over-expresses TIMP-4 and/or has aberrant TIMP-4 activity/function, e.g., overactivity. The methods comprise administering a therapeutically effective amount of the anti-TIMP-4 antibodies of the invention to a subject, e.g.,' as part of a pharmaceutical preparation.
La présente invention concerne des compositions et des procédés permettant de traiter des maladies et des troubles exprimant un inhibiteur tissulaire de la métalooprotéinase-4 (TIMP-4). La présente invention concerne de nouvelles molécules anticorps et leurs fragments immunologiquement spécifiques pour la TIMP-4. Dans un mode de réalisation particulier, la maladie ou le trouble est un cancer, particulièrement un cancer du sein, du cerveau, de l'ovaire et/ou de l'œsophage, ou une arthrose ou une maladie cardiovasculaire. Dans un mode de réalisation particulier, le cancer sur-exprime TIMP-4 et/ou présente une activité/fonction TIMP-4 aberrante, par ex. une suractivité. Les procédés consistent à administrer une quantité thérapeutiquement efficace des anticorps anti-TIMP-4 de l'invention à un sujet, par ex. sous forme d'une préparation pharmaceutique.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING |
| title | ANTI-TISSUE INHIBITOR OF METALLOPROTEINASE-4 (TIMP-4) ANTIBODIES AND METHODS OF USE THEREOF |
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