SOLID FORM OF ABIRATERONE ACETATE
Combinations of (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) with acidic substances such as citric acid, ascorbic acid, methyl-4-hydroxy benzoate, saccharin, vanillic acid, adipic acid, maleic acid, malic acid, tartaric acidare useful as pharmaceutical preparations and...
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| creator | VIERTELHAUS, MARTIN WEISHAAR, WALTER SZELAGIEWICZ, MARTIN HAFNER, ANDREAS SALVADOR, BEATE CHIODO, TIZIANA HINTERMANN, TOBIAS BLATTER, FRITZ VOSSEN, MARCUS |
| description | Combinations of (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) with acidic substances such as citric acid, ascorbic acid, methyl-4-hydroxy benzoate, saccharin, vanillic acid, adipic acid, maleic acid, malic acid, tartaric acidare useful as pharmaceutical preparations and show improved properties such as aqueous solubility and dissolution kinetics, especially in the form of cocrystals or their combination with a suitable acid.
Cette invention concerne des combinaisons d'acétate de (3β)-17-(pyridin-3-yl)androsta-5,16-dién-3-yle (acétate d'abiratérone) avec des substances acides telles que l'acide citrique, l'acide ascorbique, le méthyl-4-hydroxybenzoate, la saccharine, l'acide vanillique, l'acide adipique, l'acide maléique, l'acide malique, l'acide tartrique qui sont utiles à titre de préparations pharmaceutiques et présentent des propriétés améliorées telles que la solubilité aqueuse et la cinétique de dissolution, notamment sous la forme de co-cristaux ou de leur combinaison avec un acide convenable. |
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Cette invention concerne des combinaisons d'acétate de (3β)-17-(pyridin-3-yl)androsta-5,16-dién-3-yle (acétate d'abiratérone) avec des substances acides telles que l'acide citrique, l'acide ascorbique, le méthyl-4-hydroxybenzoate, la saccharine, l'acide vanillique, l'acide adipique, l'acide maléique, l'acide malique, l'acide tartrique qui sont utiles à titre de préparations pharmaceutiques et présentent des propriétés améliorées telles que la solubilité aqueuse et la cinétique de dissolution, notamment sous la forme de co-cristaux ou de leur combinaison avec un acide convenable.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; STEROIDS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150618&DB=EPODOC&CC=WO&NR=2015086596A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150618&DB=EPODOC&CC=WO&NR=2015086596A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VIERTELHAUS, MARTIN</creatorcontrib><creatorcontrib>WEISHAAR, WALTER</creatorcontrib><creatorcontrib>SZELAGIEWICZ, MARTIN</creatorcontrib><creatorcontrib>HAFNER, ANDREAS</creatorcontrib><creatorcontrib>SALVADOR, BEATE</creatorcontrib><creatorcontrib>CHIODO, TIZIANA</creatorcontrib><creatorcontrib>HINTERMANN, TOBIAS</creatorcontrib><creatorcontrib>BLATTER, FRITZ</creatorcontrib><creatorcontrib>VOSSEN, MARCUS</creatorcontrib><title>SOLID FORM OF ABIRATERONE ACETATE</title><description>Combinations of (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) with acidic substances such as citric acid, ascorbic acid, methyl-4-hydroxy benzoate, saccharin, vanillic acid, adipic acid, maleic acid, malic acid, tartaric acidare useful as pharmaceutical preparations and show improved properties such as aqueous solubility and dissolution kinetics, especially in the form of cocrystals or their combination with a suitable acid.
Cette invention concerne des combinaisons d'acétate de (3β)-17-(pyridin-3-yl)androsta-5,16-dién-3-yle (acétate d'abiratérone) avec des substances acides telles que l'acide citrique, l'acide ascorbique, le méthyl-4-hydroxybenzoate, la saccharine, l'acide vanillique, l'acide adipique, l'acide maléique, l'acide malique, l'acide tartrique qui sont utiles à titre de préparations pharmaceutiques et présentent des propriétés améliorées telles que la solubilité aqueuse et la cinétique de dissolution, notamment sous la forme de co-cristaux ou de leur combinaison avec un acide convenable.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAM9vfxdFFw8w_yVfB3U3B08gxyDHEN8vdzVXB0dg0BsnkYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXy4v5GBoamBhZmppZmjoTFxqgCIoSLz</recordid><startdate>20150618</startdate><enddate>20150618</enddate><creator>VIERTELHAUS, MARTIN</creator><creator>WEISHAAR, WALTER</creator><creator>SZELAGIEWICZ, MARTIN</creator><creator>HAFNER, ANDREAS</creator><creator>SALVADOR, BEATE</creator><creator>CHIODO, TIZIANA</creator><creator>HINTERMANN, TOBIAS</creator><creator>BLATTER, FRITZ</creator><creator>VOSSEN, MARCUS</creator><scope>EVB</scope></search><sort><creationdate>20150618</creationdate><title>SOLID FORM OF ABIRATERONE ACETATE</title><author>VIERTELHAUS, MARTIN ; WEISHAAR, WALTER ; SZELAGIEWICZ, MARTIN ; HAFNER, ANDREAS ; SALVADOR, BEATE ; CHIODO, TIZIANA ; HINTERMANN, TOBIAS ; BLATTER, FRITZ ; VOSSEN, MARCUS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2015086596A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>VIERTELHAUS, MARTIN</creatorcontrib><creatorcontrib>WEISHAAR, WALTER</creatorcontrib><creatorcontrib>SZELAGIEWICZ, MARTIN</creatorcontrib><creatorcontrib>HAFNER, ANDREAS</creatorcontrib><creatorcontrib>SALVADOR, BEATE</creatorcontrib><creatorcontrib>CHIODO, TIZIANA</creatorcontrib><creatorcontrib>HINTERMANN, TOBIAS</creatorcontrib><creatorcontrib>BLATTER, FRITZ</creatorcontrib><creatorcontrib>VOSSEN, MARCUS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VIERTELHAUS, MARTIN</au><au>WEISHAAR, WALTER</au><au>SZELAGIEWICZ, MARTIN</au><au>HAFNER, ANDREAS</au><au>SALVADOR, BEATE</au><au>CHIODO, TIZIANA</au><au>HINTERMANN, TOBIAS</au><au>BLATTER, FRITZ</au><au>VOSSEN, MARCUS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SOLID FORM OF ABIRATERONE ACETATE</title><date>2015-06-18</date><risdate>2015</risdate><abstract>Combinations of (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) with acidic substances such as citric acid, ascorbic acid, methyl-4-hydroxy benzoate, saccharin, vanillic acid, adipic acid, maleic acid, malic acid, tartaric acidare useful as pharmaceutical preparations and show improved properties such as aqueous solubility and dissolution kinetics, especially in the form of cocrystals or their combination with a suitable acid.
Cette invention concerne des combinaisons d'acétate de (3β)-17-(pyridin-3-yl)androsta-5,16-dién-3-yle (acétate d'abiratérone) avec des substances acides telles que l'acide citrique, l'acide ascorbique, le méthyl-4-hydroxybenzoate, la saccharine, l'acide vanillique, l'acide adipique, l'acide maléique, l'acide malique, l'acide tartrique qui sont utiles à titre de préparations pharmaceutiques et présentent des propriétés améliorées telles que la solubilité aqueuse et la cinétique de dissolution, notamment sous la forme de co-cristaux ou de leur combinaison avec un acide convenable.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS |
| title | SOLID FORM OF ABIRATERONE ACETATE |
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