PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE
The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and...
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| creator | PLUSCHKE, GERD GEIB, NINA GHASPARIAN, ARIN JUD, MAJA MARRERO NODARSE, ANIEBRYS ROBINSON, JOHN ANTHONY TAMBORINI, MARCO ZUNIGA, ARMANDO |
| description | The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.
La présente invention concerne des lipopeptides constitués d'une chaîne peptidique comprenant un domaine en superhélice parallèle, un antigène peptidique riche en proline, et une fraction lipidique, tous liés de manière covalente, qui s'agrègent en particules pseudo-virales de synthèse. Les antigènes peptidiques riches en proline étudiés contiennent des acides aminés chargés négativement et positivement, et au moins 15 % des acides aminés sont une proline. De telles particules pseudo-virales de synthèse portant des antigènes riches en proline dérivés de protéines pneumococciques sont utiles comme vaccins contre des maladies infectieuses provoquées par des bactéries Gram-positives telles que Streptococcus pneumoniae. |
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La présente invention concerne des lipopeptides constitués d'une chaîne peptidique comprenant un domaine en superhélice parallèle, un antigène peptidique riche en proline, et une fraction lipidique, tous liés de manière covalente, qui s'agrègent en particules pseudo-virales de synthèse. Les antigènes peptidiques riches en proline étudiés contiennent des acides aminés chargés négativement et positivement, et au moins 15 % des acides aminés sont une proline. De telles particules pseudo-virales de synthèse portant des antigènes riches en proline dérivés de protéines pneumococciques sont utiles comme vaccins contre des maladies infectieuses provoquées par des bactéries Gram-positives telles que Streptococcus pneumoniae.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150611&DB=EPODOC&CC=WO&NR=2015082501A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150611&DB=EPODOC&CC=WO&NR=2015082501A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PLUSCHKE, GERD</creatorcontrib><creatorcontrib>GEIB, NINA</creatorcontrib><creatorcontrib>GHASPARIAN, ARIN</creatorcontrib><creatorcontrib>JUD, MAJA</creatorcontrib><creatorcontrib>MARRERO NODARSE, ANIEBRYS</creatorcontrib><creatorcontrib>ROBINSON, JOHN ANTHONY</creatorcontrib><creatorcontrib>TAMBORINI, MARCO</creatorcontrib><creatorcontrib>ZUNIGA, ARMANDO</creatorcontrib><title>PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE</title><description>The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.
La présente invention concerne des lipopeptides constitués d'une chaîne peptidique comprenant un domaine en superhélice parallèle, un antigène peptidique riche en proline, et une fraction lipidique, tous liés de manière covalente, qui s'agrègent en particules pseudo-virales de synthèse. Les antigènes peptidiques riches en proline étudiés contiennent des acides aminés chargés négativement et positivement, et au moins 15 % des acides aminés sont une proline. De telles particules pseudo-virales de synthèse portant des antigènes riches en proline dérivés de protéines pneumococciques sont utiles comme vaccins contre des maladies infectieuses provoquées par des bactéries Gram-positives telles que Streptococcus pneumoniae.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDALCPL38fRz1Q3ydPZQCHANCPF0cQ1WAIqGuDqHeIa5Kji6O3r6BYcoBOspBPi5hvr6-3k6uvIwsKYl5hSn8kJpbgZlN9cQZw_d1IL8-NTigsTk1LzUkvhwfyMDQ1MDCyNTA0NHQ2PiVAEAw3so5Q</recordid><startdate>20150611</startdate><enddate>20150611</enddate><creator>PLUSCHKE, GERD</creator><creator>GEIB, NINA</creator><creator>GHASPARIAN, ARIN</creator><creator>JUD, MAJA</creator><creator>MARRERO NODARSE, ANIEBRYS</creator><creator>ROBINSON, JOHN ANTHONY</creator><creator>TAMBORINI, MARCO</creator><creator>ZUNIGA, ARMANDO</creator><scope>EVB</scope></search><sort><creationdate>20150611</creationdate><title>PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE</title><author>PLUSCHKE, GERD ; GEIB, NINA ; GHASPARIAN, ARIN ; JUD, MAJA ; MARRERO NODARSE, ANIEBRYS ; ROBINSON, JOHN ANTHONY ; TAMBORINI, MARCO ; ZUNIGA, ARMANDO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2015082501A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>PLUSCHKE, GERD</creatorcontrib><creatorcontrib>GEIB, NINA</creatorcontrib><creatorcontrib>GHASPARIAN, ARIN</creatorcontrib><creatorcontrib>JUD, MAJA</creatorcontrib><creatorcontrib>MARRERO NODARSE, ANIEBRYS</creatorcontrib><creatorcontrib>ROBINSON, JOHN ANTHONY</creatorcontrib><creatorcontrib>TAMBORINI, MARCO</creatorcontrib><creatorcontrib>ZUNIGA, ARMANDO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PLUSCHKE, GERD</au><au>GEIB, NINA</au><au>GHASPARIAN, ARIN</au><au>JUD, MAJA</au><au>MARRERO NODARSE, ANIEBRYS</au><au>ROBINSON, JOHN ANTHONY</au><au>TAMBORINI, MARCO</au><au>ZUNIGA, ARMANDO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE</title><date>2015-06-11</date><risdate>2015</risdate><abstract>The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.
La présente invention concerne des lipopeptides constitués d'une chaîne peptidique comprenant un domaine en superhélice parallèle, un antigène peptidique riche en proline, et une fraction lipidique, tous liés de manière covalente, qui s'agrègent en particules pseudo-virales de synthèse. Les antigènes peptidiques riches en proline étudiés contiennent des acides aminés chargés négativement et positivement, et au moins 15 % des acides aminés sont une proline. De telles particules pseudo-virales de synthèse portant des antigènes riches en proline dérivés de protéines pneumococciques sont utiles comme vaccins contre des maladies infectieuses provoquées par des bactéries Gram-positives telles que Streptococcus pneumoniae.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE |
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