COMPLEXES OF FULVESTRANT AND ITS DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

COMPLEXES OF FULVESTRANT AND ITS DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to pharmaceutically acceptable complex formulae comprising complexes of Fulvestrant, or a salt, or derivatives thereof and pharmaceutically acceptable excipients, process for the preparation thereof and pharmaceutical compositions containing them. The complex formulae o...

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Hauptverfasser: ÖTVÖS, ZSOLT, FENYVESI, ZSÓFIA, KÁRPÁTI, RICHARD, BALÁZS, HELTOVICS, GÁBOR, FILIPCSEI, GENOVÉVA, ANGI, ERZSÉBET, RÉKA, SOLYMOSI, TAMÁS, MOLNÁR, LÁSZLÓ, GLAVINAS, HRISTOS, FERENCZI, KATALIN
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Sprache:eng ; fre
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator ÖTVÖS, ZSOLT
FENYVESI, ZSÓFIA
KÁRPÁTI, RICHARD, BALÁZS
HELTOVICS, GÁBOR
FILIPCSEI, GENOVÉVA
ANGI, ERZSÉBET, RÉKA
SOLYMOSI, TAMÁS
MOLNÁR, LÁSZLÓ
GLAVINAS, HRISTOS
FERENCZI, KATALIN
description The present invention relates to pharmaceutically acceptable complex formulae comprising complexes of Fulvestrant, or a salt, or derivatives thereof and pharmaceutically acceptable excipients, process for the preparation thereof and pharmaceutical compositions containing them. The complex formulae of the present invention have improved physicochemical properties which makes the compound orally available and makes oral administration of the compound possible in the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. La présente invention concerne des formules de complexes pharmaceutiquement acceptables comprenant des complexes de Fulvestrant, ou un sel ou des dérivés de ces derniers, et des excipients pharmaceutiquement acceptables, un procédé pour leur préparation et des compositions pharmaceutiques les contenant. Les formules de complexes de la présente invention ont des caractéristiques physico-chimiques améliorées qui rendent oralement disponible le composé et rendent possible l'administration orale du composé pendant le traitement de cancer du sein métastatique à récepteurs hormonaux positifs chez des femmes ménopausées ayant une progression de maladie suite à une thérapie anti-œstrogène.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title COMPLEXES OF FULVESTRANT AND ITS DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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