FUSED PROTEINS OF GRANULOCYTE COLONY-STIMULATING FACTOR WITH OTHER PARTNERS OF GROWTH FACTOR, PREFERABLY WITH STEM CELL FACTOR, AND METHOD OF PREPARATION THEREOF
Abstract Invention is disclosing method for preparation and biological properties of fused proteins, mainly heterodimer of granulocyte colony-stimulating factor and stem cell factor. Multimer constructions according to this invention may be used in therapy, since are characterized by synergy of in v...
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| creator | PLECKAITYTE, MILDA ZVIRBLYTE, GITANA MISTINIENE, EDITA PESLIAKAS, JONAS HENRIKAS PETREIKYTE, INDRE STIRKE, ARUNAS ZVIRBLIS, GINTAUTAS LEIVA, AUDRIUS |
| description | Abstract Invention is disclosing method for preparation and biological properties of fused proteins, mainly heterodimer of granulocyte colony-stimulating factor and stem cell factor. Multimer constructions according to this invention may be used in therapy, since are characterized by synergy of in vivo functioning and extended circulation half-life in comparison to each separate protein monomer.
Cette invention concerne un procédé de préparation de protéines de fusion et leurs propriétés biologiques, lesdites protéines de fusion étant principalement constituées d'un facteur de stimulation des colonies granulocytaires hétérodimère et d'un facteur de croissance de cellules souches. Les constructions multimères selon l'invention peuvent être utilisées en thérapie, puisqu'elles sont caractérisées par une synergie de fonctionnement in vivo et une demi-vie en circulation étendue comparativement à chaque protéine monomère séparée.˙ |
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Cette invention concerne un procédé de préparation de protéines de fusion et leurs propriétés biologiques, lesdites protéines de fusion étant principalement constituées d'un facteur de stimulation des colonies granulocytaires hétérodimère et d'un facteur de croissance de cellules souches. Les constructions multimères selon l'invention peuvent être utilisées en thérapie, puisqu'elles sont caractérisées par une synergie de fonctionnement in vivo et une demi-vie en circulation étendue comparativement à chaque protéine monomère séparée.˙</description><language>eng ; fre</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150521&DB=EPODOC&CC=WO&NR=2015047062A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150521&DB=EPODOC&CC=WO&NR=2015047062A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PLECKAITYTE, MILDA</creatorcontrib><creatorcontrib>ZVIRBLYTE, GITANA</creatorcontrib><creatorcontrib>MISTINIENE, EDITA</creatorcontrib><creatorcontrib>PESLIAKAS, JONAS HENRIKAS</creatorcontrib><creatorcontrib>PETREIKYTE, INDRE</creatorcontrib><creatorcontrib>STIRKE, ARUNAS</creatorcontrib><creatorcontrib>ZVIRBLIS, GINTAUTAS</creatorcontrib><creatorcontrib>LEIVA, AUDRIUS</creatorcontrib><title>FUSED PROTEINS OF GRANULOCYTE COLONY-STIMULATING FACTOR WITH OTHER PARTNERS OF GROWTH FACTOR, PREFERABLY WITH STEM CELL FACTOR, AND METHOD OF PREPARATION THEREOF</title><description>Abstract Invention is disclosing method for preparation and biological properties of fused proteins, mainly heterodimer of granulocyte colony-stimulating factor and stem cell factor. Multimer constructions according to this invention may be used in therapy, since are characterized by synergy of in vivo functioning and extended circulation half-life in comparison to each separate protein monomer.
Cette invention concerne un procédé de préparation de protéines de fusion et leurs propriétés biologiques, lesdites protéines de fusion étant principalement constituées d'un facteur de stimulation des colonies granulocytaires hétérodimère et d'un facteur de croissance de cellules souches. Les constructions multimères selon l'invention peuvent être utilisées en thérapie, puisqu'elles sont caractérisées par une synergie de fonctionnement in vivo et une demi-vie en circulation étendue comparativement à chaque protéine monomère séparée.˙</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjT8LwjAQR7s4iPodDlwt1P9zTC-mkOZKcqV0EpE4iRb0C_lNTbE4O93we-_dOHmr2mMOlSPGwnogBUcnbG1ItowgyZBtU89FWRvBhT2CEpLJQVOwBmKNDirh2KIbZGri8IUWsYsKnTiY9it4xhIkGvMjhM2hRNaU93rkYy0-Igt9G0lNk9H1fHuG2XAnyVwhS52G7nEKz-58CffwOjW0ypbbbLPPdiuxWf9HfQAlL0Zh</recordid><startdate>20150521</startdate><enddate>20150521</enddate><creator>PLECKAITYTE, MILDA</creator><creator>ZVIRBLYTE, GITANA</creator><creator>MISTINIENE, EDITA</creator><creator>PESLIAKAS, JONAS HENRIKAS</creator><creator>PETREIKYTE, INDRE</creator><creator>STIRKE, ARUNAS</creator><creator>ZVIRBLIS, GINTAUTAS</creator><creator>LEIVA, AUDRIUS</creator><scope>EVB</scope></search><sort><creationdate>20150521</creationdate><title>FUSED PROTEINS OF GRANULOCYTE COLONY-STIMULATING FACTOR WITH OTHER PARTNERS OF GROWTH FACTOR, PREFERABLY WITH STEM CELL FACTOR, AND METHOD OF PREPARATION THEREOF</title><author>PLECKAITYTE, MILDA ; ZVIRBLYTE, GITANA ; MISTINIENE, EDITA ; PESLIAKAS, JONAS HENRIKAS ; PETREIKYTE, INDRE ; STIRKE, ARUNAS ; ZVIRBLIS, GINTAUTAS ; LEIVA, AUDRIUS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2015047062A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>PLECKAITYTE, MILDA</creatorcontrib><creatorcontrib>ZVIRBLYTE, GITANA</creatorcontrib><creatorcontrib>MISTINIENE, EDITA</creatorcontrib><creatorcontrib>PESLIAKAS, JONAS HENRIKAS</creatorcontrib><creatorcontrib>PETREIKYTE, INDRE</creatorcontrib><creatorcontrib>STIRKE, ARUNAS</creatorcontrib><creatorcontrib>ZVIRBLIS, GINTAUTAS</creatorcontrib><creatorcontrib>LEIVA, AUDRIUS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PLECKAITYTE, MILDA</au><au>ZVIRBLYTE, GITANA</au><au>MISTINIENE, EDITA</au><au>PESLIAKAS, JONAS HENRIKAS</au><au>PETREIKYTE, INDRE</au><au>STIRKE, ARUNAS</au><au>ZVIRBLIS, GINTAUTAS</au><au>LEIVA, AUDRIUS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FUSED PROTEINS OF GRANULOCYTE COLONY-STIMULATING FACTOR WITH OTHER PARTNERS OF GROWTH FACTOR, PREFERABLY WITH STEM CELL FACTOR, AND METHOD OF PREPARATION THEREOF</title><date>2015-05-21</date><risdate>2015</risdate><abstract>Abstract Invention is disclosing method for preparation and biological properties of fused proteins, mainly heterodimer of granulocyte colony-stimulating factor and stem cell factor. Multimer constructions according to this invention may be used in therapy, since are characterized by synergy of in vivo functioning and extended circulation half-life in comparison to each separate protein monomer.
Cette invention concerne un procédé de préparation de protéines de fusion et leurs propriétés biologiques, lesdites protéines de fusion étant principalement constituées d'un facteur de stimulation des colonies granulocytaires hétérodimère et d'un facteur de croissance de cellules souches. Les constructions multimères selon l'invention peuvent être utilisées en thérapie, puisqu'elles sont caractérisées par une synergie de fonctionnement in vivo et une demi-vie en circulation étendue comparativement à chaque protéine monomère séparée.˙</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES |
| title | FUSED PROTEINS OF GRANULOCYTE COLONY-STIMULATING FACTOR WITH OTHER PARTNERS OF GROWTH FACTOR, PREFERABLY WITH STEM CELL FACTOR, AND METHOD OF PREPARATION THEREOF |
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