BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS
The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disord...
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| creator | DIMAURO, ERIN F GRACEFFA, RUSSELL SPARLING, BRIAN NGUYEN, HANH NHO BOEZIO, CHRISTIANE PETERSON, EMILY MARX, ISAAC E LA, DANIEL HUANG, HONGBIN GUZMAN-PEREZ, ANGEL KREIMAN, CHARLES ROMERO, KARINA BUTLER, JOHN R MILGRIM, BENJAMIN CHARLES CHU-MOYER, MARGARET YUHUA WEISS, MATTHEW BOEZIO, ALESSANDRO DINEEN, THOMAS |
| description | The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
La présente invention concerne des composés de formule (I), et des sels pharmaceutiquement acceptables de ceux-ci, lesquels sont des inhibiteurs de canaux sodiques sensibles à la tension, en particulier, Nav1.7. Ces composés sont utiles pour le traitement de maladies associées à l'activité de canaux sodiques, telles que les troubles de la douleur et la gale. L'invention concerne également des compositions pharmaceutiques contenant des composés de ladite présente invention. |
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La présente invention concerne des composés de formule (I), et des sels pharmaceutiquement acceptables de ceux-ci, lesquels sont des inhibiteurs de canaux sodiques sensibles à la tension, en particulier, Nav1.7. Ces composés sont utiles pour le traitement de maladies associées à l'activité de canaux sodiques, telles que les troubles de la douleur et la gale. L'invention concerne également des compositions pharmaceutiques contenant des composés de ladite présente invention.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141218&DB=EPODOC&CC=WO&NR=2014201206A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141218&DB=EPODOC&CC=WO&NR=2014201206A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DIMAURO, ERIN F</creatorcontrib><creatorcontrib>GRACEFFA, RUSSELL</creatorcontrib><creatorcontrib>SPARLING, BRIAN</creatorcontrib><creatorcontrib>NGUYEN, HANH NHO</creatorcontrib><creatorcontrib>BOEZIO, CHRISTIANE</creatorcontrib><creatorcontrib>PETERSON, EMILY</creatorcontrib><creatorcontrib>MARX, ISAAC E</creatorcontrib><creatorcontrib>LA, DANIEL</creatorcontrib><creatorcontrib>HUANG, HONGBIN</creatorcontrib><creatorcontrib>GUZMAN-PEREZ, ANGEL</creatorcontrib><creatorcontrib>KREIMAN, CHARLES</creatorcontrib><creatorcontrib>ROMERO, KARINA</creatorcontrib><creatorcontrib>BUTLER, JOHN R</creatorcontrib><creatorcontrib>MILGRIM, BENJAMIN CHARLES</creatorcontrib><creatorcontrib>CHU-MOYER, MARGARET YUHUA</creatorcontrib><creatorcontrib>WEISS, MATTHEW</creatorcontrib><creatorcontrib>BOEZIO, ALESSANDRO</creatorcontrib><creatorcontrib>DINEEN, THOMAS</creatorcontrib><title>BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS</title><description>The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
La présente invention concerne des composés de formule (I), et des sels pharmaceutiquement acceptables de ceux-ci, lesquels sont des inhibiteurs de canaux sodiques sensibles à la tension, en particulier, Nav1.7. Ces composés sont utiles pour le traitement de maladies associées à l'activité de canaux sodiques, telles que les troubles de la douleur et la gale. 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The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
La présente invention concerne des composés de formule (I), et des sels pharmaceutiquement acceptables de ceux-ci, lesquels sont des inhibiteurs de canaux sodiques sensibles à la tension, en particulier, Nav1.7. Ces composés sont utiles pour le traitement de maladies associées à l'activité de canaux sodiques, telles que les troubles de la douleur et la gale. L'invention concerne également des compositions pharmaceutiques contenant des composés de ladite présente invention.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS |
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