THROMBIN SENSITIVE COAGULATION FACTOR X MOLECULES
The present invention relates to thrombin sensitive coagulation Factor X (FX), as well as use thereof in medicine. In particular the invention relates to FX molecules comprising 2 to 10 amino acid modifications in the activation peptide N-terminally of the FX "IVGG" motif as well as compos...
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| creator | HANSEN, JENS JACOB WINTHER BALLING, KRISTOFFER GANDHI, PRAFULL S BREINHOLT, JENS BUCHARDT, JENS BLOUSE, GRANT E ØSTERGAARD, HENRIK |
| description | The present invention relates to thrombin sensitive coagulation Factor X (FX), as well as use thereof in medicine. In particular the invention relates to FX molecules comprising 2 to 10 amino acid modifications in the activation peptide N-terminally of the FX "IVGG" motif as well as compositions comprising such molecules and use thereof. Such molecules may be useful in connection with convenient and patient friendly treatment regimens in treatment and prophylaxis of haemophilia.
La présente invention concerne le facteur de coagulation X sensible à la thrombine (FX), ainsi que son utilisation dans des médicaments. En particulier, l'invention concerne des molécules de FX comprenant 2 à 10 modifications d'acides aminés dans le peptide d'activation en position N-terminale du motif « IVGG » de FX ainsi que des compositions comprenant lesdites molécules et leur utilisation. Lesdites molécules peuvent être utiles en rapport avec des schémas thérapeutiques pratiques et conviviaux pour les patients dans le traitement et la prophylaxie de l'hémophilie. |
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La présente invention concerne le facteur de coagulation X sensible à la thrombine (FX), ainsi que son utilisation dans des médicaments. En particulier, l'invention concerne des molécules de FX comprenant 2 à 10 modifications d'acides aminés dans le peptide d'activation en position N-terminale du motif « IVGG » de FX ainsi que des compositions comprenant lesdites molécules et leur utilisation. Lesdites molécules peuvent être utiles en rapport avec des schémas thérapeutiques pratiques et conviviaux pour les patients dans le traitement et la prophylaxie de l'hémophilie.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141106&DB=EPODOC&CC=WO&NR=2014140103A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141106&DB=EPODOC&CC=WO&NR=2014140103A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HANSEN, JENS JACOB</creatorcontrib><creatorcontrib>WINTHER BALLING, KRISTOFFER</creatorcontrib><creatorcontrib>GANDHI, PRAFULL S</creatorcontrib><creatorcontrib>BREINHOLT, JENS</creatorcontrib><creatorcontrib>BUCHARDT, JENS</creatorcontrib><creatorcontrib>BLOUSE, GRANT E</creatorcontrib><creatorcontrib>ØSTERGAARD, HENRIK</creatorcontrib><title>THROMBIN SENSITIVE COAGULATION FACTOR X MOLECULES</title><description>The present invention relates to thrombin sensitive coagulation Factor X (FX), as well as use thereof in medicine. In particular the invention relates to FX molecules comprising 2 to 10 amino acid modifications in the activation peptide N-terminally of the FX "IVGG" motif as well as compositions comprising such molecules and use thereof. Such molecules may be useful in connection with convenient and patient friendly treatment regimens in treatment and prophylaxis of haemophilia.
La présente invention concerne le facteur de coagulation X sensible à la thrombine (FX), ainsi que son utilisation dans des médicaments. En particulier, l'invention concerne des molécules de FX comprenant 2 à 10 modifications d'acides aminés dans le peptide d'activation en position N-terminale du motif « IVGG » de FX ainsi que des compositions comprenant lesdites molécules et leur utilisation. Lesdites molécules peuvent être utiles en rapport avec des schémas thérapeutiques pratiques et conviviaux pour les patients dans le traitement et la prophylaxie de l'hémophilie.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAM8Qjy93Xy9FMIdvUL9gzxDHNVcPZ3dA_1cQzx9PdTcHN0DvEPUohQ8PX3cXUO9XEN5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgaGJoYmBoYGxo7GxsSpAgALBief</recordid><startdate>20141106</startdate><enddate>20141106</enddate><creator>HANSEN, JENS JACOB</creator><creator>WINTHER BALLING, KRISTOFFER</creator><creator>GANDHI, PRAFULL S</creator><creator>BREINHOLT, JENS</creator><creator>BUCHARDT, JENS</creator><creator>BLOUSE, GRANT E</creator><creator>ØSTERGAARD, HENRIK</creator><scope>EVB</scope></search><sort><creationdate>20141106</creationdate><title>THROMBIN SENSITIVE COAGULATION FACTOR X MOLECULES</title><author>HANSEN, JENS JACOB ; WINTHER BALLING, KRISTOFFER ; GANDHI, PRAFULL S ; BREINHOLT, JENS ; BUCHARDT, JENS ; BLOUSE, GRANT E ; ØSTERGAARD, HENRIK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2014140103A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2014</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>HANSEN, JENS JACOB</creatorcontrib><creatorcontrib>WINTHER BALLING, KRISTOFFER</creatorcontrib><creatorcontrib>GANDHI, PRAFULL S</creatorcontrib><creatorcontrib>BREINHOLT, JENS</creatorcontrib><creatorcontrib>BUCHARDT, JENS</creatorcontrib><creatorcontrib>BLOUSE, GRANT E</creatorcontrib><creatorcontrib>ØSTERGAARD, HENRIK</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HANSEN, JENS JACOB</au><au>WINTHER BALLING, KRISTOFFER</au><au>GANDHI, PRAFULL S</au><au>BREINHOLT, JENS</au><au>BUCHARDT, JENS</au><au>BLOUSE, GRANT E</au><au>ØSTERGAARD, HENRIK</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>THROMBIN SENSITIVE COAGULATION FACTOR X MOLECULES</title><date>2014-11-06</date><risdate>2014</risdate><abstract>The present invention relates to thrombin sensitive coagulation Factor X (FX), as well as use thereof in medicine. In particular the invention relates to FX molecules comprising 2 to 10 amino acid modifications in the activation peptide N-terminally of the FX "IVGG" motif as well as compositions comprising such molecules and use thereof. Such molecules may be useful in connection with convenient and patient friendly treatment regimens in treatment and prophylaxis of haemophilia.
La présente invention concerne le facteur de coagulation X sensible à la thrombine (FX), ainsi que son utilisation dans des médicaments. En particulier, l'invention concerne des molécules de FX comprenant 2 à 10 modifications d'acides aminés dans le peptide d'activation en position N-terminale du motif « IVGG » de FX ainsi que des compositions comprenant lesdites molécules et leur utilisation. Lesdites molécules peuvent être utiles en rapport avec des schémas thérapeutiques pratiques et conviviaux pour les patients dans le traitement et la prophylaxie de l'hémophilie.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | THROMBIN SENSITIVE COAGULATION FACTOR X MOLECULES |
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