PROCESS FOR PREPARING ATAZANAVIR SULPHATE
The present invention relates to a process for the preparation of Compound (A): (Formula (A)) wherein the process comprises contacting atazanavir base (Compound (II)) with sulphuric acid in a combination of two or more solvents and isolating compound (A). The present invention also relates to substa...
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| creator | CHINIMILLI, VENUGOPALARAO PATHI, SRINIVAS LAXMINARAYAN KANKAN, RAJENDRA NARAYANRAO |
| description | The present invention relates to a process for the preparation of Compound (A): (Formula (A)) wherein the process comprises contacting atazanavir base (Compound (II)) with sulphuric acid in a combination of two or more solvents and isolating compound (A). The present invention also relates to substantially pure Compound (A), and to Compound (A) devoid of mesityl oxide impurity. Mesityl oxide has the following formula: (Formula (B)).
La présente invention concerne un procédé de préparation du Composé (A) : (Formule (A)), ledit procédé consistant à mettre en contact la base d'atazanavir (Composé (II)) avec de l'acide sulfurique dans une combinaison de deux solvants ou plus et à isoler le Composé (A). La présente invention concerne également un Composé (A) pratiquement pur, et un Composé (A) exempt de l'impureté oxyde de mésityle. L'oxyde de mésityle est représenté par la formule suivante : (Formule (B)). |
| format | Patent |
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La présente invention concerne un procédé de préparation du Composé (A) : (Formule (A)), ledit procédé consistant à mettre en contact la base d'atazanavir (Composé (II)) avec de l'acide sulfurique dans une combinaison de deux solvants ou plus et à isoler le Composé (A). La présente invention concerne également un Composé (A) pratiquement pur, et un Composé (A) exempt de l'impureté oxyde de mésityle. L'oxyde de mésityle est représenté par la formule suivante : (Formule (B)).</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141030&DB=EPODOC&CC=WO&NR=2014125270A8$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141030&DB=EPODOC&CC=WO&NR=2014125270A8$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHINIMILLI, VENUGOPALARAO</creatorcontrib><creatorcontrib>PATHI, SRINIVAS LAXMINARAYAN</creatorcontrib><creatorcontrib>KANKAN, RAJENDRA NARAYANRAO</creatorcontrib><title>PROCESS FOR PREPARING ATAZANAVIR SULPHATE</title><description>The present invention relates to a process for the preparation of Compound (A): (Formula (A)) wherein the process comprises contacting atazanavir base (Compound (II)) with sulphuric acid in a combination of two or more solvents and isolating compound (A). The present invention also relates to substantially pure Compound (A), and to Compound (A) devoid of mesityl oxide impurity. Mesityl oxide has the following formula: (Formula (B)).
La présente invention concerne un procédé de préparation du Composé (A) : (Formule (A)), ledit procédé consistant à mettre en contact la base d'atazanavir (Composé (II)) avec de l'acide sulfurique dans une combinaison de deux solvants ou plus et à isoler le Composé (A). La présente invention concerne également un Composé (A) pratiquement pur, et un Composé (A) exempt de l'impureté oxyde de mésityle. L'oxyde de mésityle est représenté par la formule suivante : (Formule (B)).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAMCPJ3dg0OVnDzD1IICHINcAzy9HNXcAxxjHL0cwzzDFIIDvUJ8HAMceVhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGhiaGRqZG5gaOFsbEqQIA1uglgw</recordid><startdate>20141030</startdate><enddate>20141030</enddate><creator>CHINIMILLI, VENUGOPALARAO</creator><creator>PATHI, SRINIVAS LAXMINARAYAN</creator><creator>KANKAN, RAJENDRA NARAYANRAO</creator><scope>EVB</scope></search><sort><creationdate>20141030</creationdate><title>PROCESS FOR PREPARING ATAZANAVIR SULPHATE</title><author>CHINIMILLI, VENUGOPALARAO ; PATHI, SRINIVAS LAXMINARAYAN ; KANKAN, RAJENDRA NARAYANRAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2014125270A83</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>CHINIMILLI, VENUGOPALARAO</creatorcontrib><creatorcontrib>PATHI, SRINIVAS LAXMINARAYAN</creatorcontrib><creatorcontrib>KANKAN, RAJENDRA NARAYANRAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHINIMILLI, VENUGOPALARAO</au><au>PATHI, SRINIVAS LAXMINARAYAN</au><au>KANKAN, RAJENDRA NARAYANRAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PREPARING ATAZANAVIR SULPHATE</title><date>2014-10-30</date><risdate>2014</risdate><abstract>The present invention relates to a process for the preparation of Compound (A): (Formula (A)) wherein the process comprises contacting atazanavir base (Compound (II)) with sulphuric acid in a combination of two or more solvents and isolating compound (A). The present invention also relates to substantially pure Compound (A), and to Compound (A) devoid of mesityl oxide impurity. Mesityl oxide has the following formula: (Formula (B)).
La présente invention concerne un procédé de préparation du Composé (A) : (Formule (A)), ledit procédé consistant à mettre en contact la base d'atazanavir (Composé (II)) avec de l'acide sulfurique dans une combinaison de deux solvants ou plus et à isoler le Composé (A). La présente invention concerne également un Composé (A) pratiquement pur, et un Composé (A) exempt de l'impureté oxyde de mésityle. L'oxyde de mésityle est représenté par la formule suivante : (Formule (B)).</abstract><oa>free_for_read</oa></addata></record> |
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| title | PROCESS FOR PREPARING ATAZANAVIR SULPHATE |
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