IMPROVED BACULOVIRAL EXPRESSION SYSTEM AND METHODS OF PRODUCING THE SAME
The present invention is based on the discovery that large parts of the genome of nucleopolyhedtovirus (NPV)-alpha baculovirus clade la viruses can be deleted with out deleterious effect on the usability of the virus comprising such genome in the infection of cells in cell culture. Accordingly, the...
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| creator | THIMIRI GOVINDA RAJ, DEEPAK BALAJI BERGER, IMRE |
| description | The present invention is based on the discovery that large parts of the genome of nucleopolyhedtovirus (NPV)-alpha baculovirus clade la viruses can be deleted with out deleterious effect on the usability of the virus comprising such genome in the infection of cells in cell culture. Accordingly, the present invention provides NPY-alpha baculovirus clade la genome which is reduced in size in comparison to the respective native NPV-alpha baculovirus clade la genome, such genomes comprising heterologous nucleotides, viruses comprising either of these genomes, cells infected with such viruses and methods for producing such viruses and cells.
La présente invention repose sur la découverte que de grandes parties du génome de virus de la clade 1a de baculovirus nucléopolyhedtovirus (NPV)-alpha peuvent être éliminées sans effet délétère sur la capacité d'utilisation du virus, comprenant un tel génome dans l'infection de cellules dans une culture cellulaire. Ainsi, la présente invention concerne le génome de la clade 1a de baculovirus NPY-alpha qui est réduit en dimension en comparaison au génome de la clade 1a de baculovirus NPV-alpha endogène respectif, de tels génomes comprenant des nucléotides hétérologues, des virus comprenant l'un ou l'autre de ces génomes, des cellules infectées par de tels virus et des procédés de production de tels virus et de telles cellules. |
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La présente invention repose sur la découverte que de grandes parties du génome de virus de la clade 1a de baculovirus nucléopolyhedtovirus (NPV)-alpha peuvent être éliminées sans effet délétère sur la capacité d'utilisation du virus, comprenant un tel génome dans l'infection de cellules dans une culture cellulaire. Ainsi, la présente invention concerne le génome de la clade 1a de baculovirus NPY-alpha qui est réduit en dimension en comparaison au génome de la clade 1a de baculovirus NPV-alpha endogène respectif, de tels génomes comprenant des nucléotides hétérologues, des virus comprenant l'un ou l'autre de ces génomes, des cellules infectées par de tels virus et des procédés de production de tels virus et de telles cellules.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150430&DB=EPODOC&CC=WO&NR=2014122629A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150430&DB=EPODOC&CC=WO&NR=2014122629A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>THIMIRI GOVINDA RAJ, DEEPAK BALAJI</creatorcontrib><creatorcontrib>BERGER, IMRE</creatorcontrib><title>IMPROVED BACULOVIRAL EXPRESSION SYSTEM AND METHODS OF PRODUCING THE SAME</title><description>The present invention is based on the discovery that large parts of the genome of nucleopolyhedtovirus (NPV)-alpha baculovirus clade la viruses can be deleted with out deleterious effect on the usability of the virus comprising such genome in the infection of cells in cell culture. Accordingly, the present invention provides NPY-alpha baculovirus clade la genome which is reduced in size in comparison to the respective native NPV-alpha baculovirus clade la genome, such genomes comprising heterologous nucleotides, viruses comprising either of these genomes, cells infected with such viruses and methods for producing such viruses and cells.
La présente invention repose sur la découverte que de grandes parties du génome de virus de la clade 1a de baculovirus nucléopolyhedtovirus (NPV)-alpha peuvent être éliminées sans effet délétère sur la capacité d'utilisation du virus, comprenant un tel génome dans l'infection de cellules dans une culture cellulaire. Ainsi, la présente invention concerne le génome de la clade 1a de baculovirus NPY-alpha qui est réduit en dimension en comparaison au génome de la clade 1a de baculovirus NPV-alpha endogène respectif, de tels génomes comprenant des nucléotides hétérologues, des virus comprenant l'un ou l'autre de ces génomes, des cellules infectées par de tels virus et des procédés de production de tels virus et de telles cellules.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPDw9A0I8g9zdVFwcnQO9fEP8wxy9FFwjQgIcg0O9vT3UwiODA5x9VVw9HNR8HUN8fB3CVbwd1MA6nEJdfb0c1cI8XBVCHb0deVhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGhiaGRkZmRpaOxsbEqQIA4PIt-g</recordid><startdate>20150430</startdate><enddate>20150430</enddate><creator>THIMIRI GOVINDA RAJ, DEEPAK BALAJI</creator><creator>BERGER, IMRE</creator><scope>EVB</scope></search><sort><creationdate>20150430</creationdate><title>IMPROVED BACULOVIRAL EXPRESSION SYSTEM AND METHODS OF PRODUCING THE SAME</title><author>THIMIRI GOVINDA RAJ, DEEPAK BALAJI ; BERGER, IMRE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2014122629A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2015</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>THIMIRI GOVINDA RAJ, DEEPAK BALAJI</creatorcontrib><creatorcontrib>BERGER, IMRE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>THIMIRI GOVINDA RAJ, DEEPAK BALAJI</au><au>BERGER, IMRE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IMPROVED BACULOVIRAL EXPRESSION SYSTEM AND METHODS OF PRODUCING THE SAME</title><date>2015-04-30</date><risdate>2015</risdate><abstract>The present invention is based on the discovery that large parts of the genome of nucleopolyhedtovirus (NPV)-alpha baculovirus clade la viruses can be deleted with out deleterious effect on the usability of the virus comprising such genome in the infection of cells in cell culture. Accordingly, the present invention provides NPY-alpha baculovirus clade la genome which is reduced in size in comparison to the respective native NPV-alpha baculovirus clade la genome, such genomes comprising heterologous nucleotides, viruses comprising either of these genomes, cells infected with such viruses and methods for producing such viruses and cells.
La présente invention repose sur la découverte que de grandes parties du génome de virus de la clade 1a de baculovirus nucléopolyhedtovirus (NPV)-alpha peuvent être éliminées sans effet délétère sur la capacité d'utilisation du virus, comprenant un tel génome dans l'infection de cellules dans une culture cellulaire. Ainsi, la présente invention concerne le génome de la clade 1a de baculovirus NPY-alpha qui est réduit en dimension en comparaison au génome de la clade 1a de baculovirus NPV-alpha endogène respectif, de tels génomes comprenant des nucléotides hétérologues, des virus comprenant l'un ou l'autre de ces génomes, des cellules infectées par de tels virus et des procédés de production de tels virus et de telles cellules.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | IMPROVED BACULOVIRAL EXPRESSION SYSTEM AND METHODS OF PRODUCING THE SAME |
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