INSULIN DERIVATIVES FOR DIABETES TREATMENT
Compounds, compositions, and methods for "smart" delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insul...
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| creator | WEBBER, MATTHEW, J KANASTY, ROSEMARY, LYNN CHOU, HUNGIEH LANGER, ROBERT, A TANG, BENJAMIN, C LEVI, YAIR ANDERSON, DANIEL, G ZHANG, YUNLONG VEGAS, ARTURO, JOSE |
| description | Compounds, compositions, and methods for "smart" delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.
L'invention concerne des composés, des compositions et des méthodes de libération "intelligente" d'un agent thérapeutique, prophylactique ou diagnostique, telle que la libération d'insuline médiée par le glucose au moyen de dérivés d'insuline sensibles au glucose. Les dérivés d'insuline fixent le sérum-albumine ou s'agglomèrent in vivo. Les dérivés d'insuline se dissocient efficacement pour libérer l'insuline dans un état hyperglycémique, la complexation du glucose en élément sensible au glucose modifiant les propriétés du dérivé d'insuline menant à la dissociation. Les composés, compositions, et méthodes permettent la mise en oeuvre d'une stratégie de libération pour la gestion du diabète à la fois auto-régulée et à long terme. |
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L'invention concerne des composés, des compositions et des méthodes de libération "intelligente" d'un agent thérapeutique, prophylactique ou diagnostique, telle que la libération d'insuline médiée par le glucose au moyen de dérivés d'insuline sensibles au glucose. Les dérivés d'insuline fixent le sérum-albumine ou s'agglomèrent in vivo. Les dérivés d'insuline se dissocient efficacement pour libérer l'insuline dans un état hyperglycémique, la complexation du glucose en élément sensible au glucose modifiant les propriétés du dérivé d'insuline menant à la dissociation. Les composés, compositions, et méthodes permettent la mise en oeuvre d'une stratégie de libération pour la gestion du diabète à la fois auto-régulée et à long terme.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140828&DB=EPODOC&CC=WO&NR=2014093696A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140828&DB=EPODOC&CC=WO&NR=2014093696A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WEBBER, MATTHEW, J</creatorcontrib><creatorcontrib>KANASTY, ROSEMARY, LYNN</creatorcontrib><creatorcontrib>CHOU, HUNGIEH</creatorcontrib><creatorcontrib>LANGER, ROBERT, A</creatorcontrib><creatorcontrib>TANG, BENJAMIN, C</creatorcontrib><creatorcontrib>LEVI, YAIR</creatorcontrib><creatorcontrib>ANDERSON, DANIEL, G</creatorcontrib><creatorcontrib>ZHANG, YUNLONG</creatorcontrib><creatorcontrib>VEGAS, ARTURO, JOSE</creatorcontrib><title>INSULIN DERIVATIVES FOR DIABETES TREATMENT</title><description>Compounds, compositions, and methods for "smart" delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.
L'invention concerne des composés, des compositions et des méthodes de libération "intelligente" d'un agent thérapeutique, prophylactique ou diagnostique, telle que la libération d'insuline médiée par le glucose au moyen de dérivés d'insuline sensibles au glucose. Les dérivés d'insuline fixent le sérum-albumine ou s'agglomèrent in vivo. Les dérivés d'insuline se dissocient efficacement pour libérer l'insuline dans un état hyperglycémique, la complexation du glucose en élément sensible au glucose modifiant les propriétés du dérivé d'insuline menant à la dissociation. 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The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.
L'invention concerne des composés, des compositions et des méthodes de libération "intelligente" d'un agent thérapeutique, prophylactique ou diagnostique, telle que la libération d'insuline médiée par le glucose au moyen de dérivés d'insuline sensibles au glucose. Les dérivés d'insuline fixent le sérum-albumine ou s'agglomèrent in vivo. Les dérivés d'insuline se dissocient efficacement pour libérer l'insuline dans un état hyperglycémique, la complexation du glucose en élément sensible au glucose modifiant les propriétés du dérivé d'insuline menant à la dissociation. Les composés, compositions, et méthodes permettent la mise en oeuvre d'une stratégie de libération pour la gestion du diabète à la fois auto-régulée et à long terme.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | INSULIN DERIVATIVES FOR DIABETES TREATMENT |
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