METHOD FOR INDUCING DIFFERENTIATION OF ARTIFICIAL PLURIPOTENT STEM CELL INTO HEPATOCYTE
[Problem] To provide: a novel method for inducing the differentiation of an artificial pluripotent stem cell into a hepatocyte with high efficiency; and a use of the method. [Solution] The differentiation of an artificial pluripotent stem cell into a hepatocyte can be induced through: a step of diff...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; jpn |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | KONDO YUKI MIYATA NAOKI YOSHIHASHI SACHIMI IWAO TAKAHIRO MATSUNAGA TAMIHIDE SUZUKI TAKAYOSHI |
| description | [Problem] To provide: a novel method for inducing the differentiation of an artificial pluripotent stem cell into a hepatocyte with high efficiency; and a use of the method. [Solution] The differentiation of an artificial pluripotent stem cell into a hepatocyte can be induced through: a step of differentiating the artificial pluripotent stem cell into an endoderm-like cell; and a step of differentiating the endoderm-like cell produced in the preceding step into a hepatocyte-like cell, in which at least a part of the culturing of the endoderm-like cell is carried out in the presence of a histone deacetylase inhibitor and/or under oxidative stress-applied conditions.
L'invention concerne : un nouveau procédé d'induction de la différenciation d'une cellule souche pluripotente artificielle en un hépatocyte avec une efficacité élevée ; et une utilisation du procédé. La solution selon l'invention consiste en la différenciation d'une cellule souche pluripotente artificielle en un hépatocyte pouvant être induite par : une étape de différenciation de la cellule souche pluripotente artificielle en une cellule du type endodermique ; et une étape de différenciation de la cellule du type endodermique produite dans l'étape précédente en une cellule du type hépatocyte, au moins une partie de la culture de la cellule du type endoderme étant réalisée en présence d'un inhibiteur d'histone désacétylase et/ou par l'application de conditions de stress oxydatif. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2013183571A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2013183571A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2013183571A13</originalsourceid><addsrcrecordid>eNqNi7EKwjAQQLs4iPoPB86CMYiuIbmYgzRX4pXiVIrESbRQ_x87-AFOb3jvLauuRgnswHMGSq61lC7gyHvMmISMECdgDyYLebJkIjSxzdSwzB6ugjVYjHGehSFgY4TtTXBdLR7DcyqbH1fV1qPYsCvjuy_TONzLq3z6jg97pdVZH0_KKP1f9QWdtDIc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHOD FOR INDUCING DIFFERENTIATION OF ARTIFICIAL PLURIPOTENT STEM CELL INTO HEPATOCYTE</title><source>esp@cenet</source><creator>KONDO YUKI ; MIYATA NAOKI ; YOSHIHASHI SACHIMI ; IWAO TAKAHIRO ; MATSUNAGA TAMIHIDE ; SUZUKI TAKAYOSHI</creator><creatorcontrib>KONDO YUKI ; MIYATA NAOKI ; YOSHIHASHI SACHIMI ; IWAO TAKAHIRO ; MATSUNAGA TAMIHIDE ; SUZUKI TAKAYOSHI</creatorcontrib><description>[Problem] To provide: a novel method for inducing the differentiation of an artificial pluripotent stem cell into a hepatocyte with high efficiency; and a use of the method. [Solution] The differentiation of an artificial pluripotent stem cell into a hepatocyte can be induced through: a step of differentiating the artificial pluripotent stem cell into an endoderm-like cell; and a step of differentiating the endoderm-like cell produced in the preceding step into a hepatocyte-like cell, in which at least a part of the culturing of the endoderm-like cell is carried out in the presence of a histone deacetylase inhibitor and/or under oxidative stress-applied conditions.
L'invention concerne : un nouveau procédé d'induction de la différenciation d'une cellule souche pluripotente artificielle en un hépatocyte avec une efficacité élevée ; et une utilisation du procédé. La solution selon l'invention consiste en la différenciation d'une cellule souche pluripotente artificielle en un hépatocyte pouvant être induite par : une étape de différenciation de la cellule souche pluripotente artificielle en une cellule du type endodermique ; et une étape de différenciation de la cellule du type endodermique produite dans l'étape précédente en une cellule du type hépatocyte, au moins une partie de la culture de la cellule du type endoderme étant réalisée en présence d'un inhibiteur d'histone désacétylase et/ou par l'application de conditions de stress oxydatif.</description><language>eng ; fre ; jpn</language><subject>BEER ; BIOCHEMISTRY ; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131212&DB=EPODOC&CC=WO&NR=2013183571A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131212&DB=EPODOC&CC=WO&NR=2013183571A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KONDO YUKI</creatorcontrib><creatorcontrib>MIYATA NAOKI</creatorcontrib><creatorcontrib>YOSHIHASHI SACHIMI</creatorcontrib><creatorcontrib>IWAO TAKAHIRO</creatorcontrib><creatorcontrib>MATSUNAGA TAMIHIDE</creatorcontrib><creatorcontrib>SUZUKI TAKAYOSHI</creatorcontrib><title>METHOD FOR INDUCING DIFFERENTIATION OF ARTIFICIAL PLURIPOTENT STEM CELL INTO HEPATOCYTE</title><description>[Problem] To provide: a novel method for inducing the differentiation of an artificial pluripotent stem cell into a hepatocyte with high efficiency; and a use of the method. [Solution] The differentiation of an artificial pluripotent stem cell into a hepatocyte can be induced through: a step of differentiating the artificial pluripotent stem cell into an endoderm-like cell; and a step of differentiating the endoderm-like cell produced in the preceding step into a hepatocyte-like cell, in which at least a part of the culturing of the endoderm-like cell is carried out in the presence of a histone deacetylase inhibitor and/or under oxidative stress-applied conditions.
L'invention concerne : un nouveau procédé d'induction de la différenciation d'une cellule souche pluripotente artificielle en un hépatocyte avec une efficacité élevée ; et une utilisation du procédé. La solution selon l'invention consiste en la différenciation d'une cellule souche pluripotente artificielle en un hépatocyte pouvant être induite par : une étape de différenciation de la cellule souche pluripotente artificielle en une cellule du type endodermique ; et une étape de différenciation de la cellule du type endodermique produite dans l'étape précédente en une cellule du type hépatocyte, au moins une partie de la culture de la cellule du type endoderme étant réalisée en présence d'un inhibiteur d'histone désacétylase et/ou par l'application de conditions de stress oxydatif.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi7EKwjAQQLs4iPoPB86CMYiuIbmYgzRX4pXiVIrESbRQ_x87-AFOb3jvLauuRgnswHMGSq61lC7gyHvMmISMECdgDyYLebJkIjSxzdSwzB6ugjVYjHGehSFgY4TtTXBdLR7DcyqbH1fV1qPYsCvjuy_TONzLq3z6jg97pdVZH0_KKP1f9QWdtDIc</recordid><startdate>20131212</startdate><enddate>20131212</enddate><creator>KONDO YUKI</creator><creator>MIYATA NAOKI</creator><creator>YOSHIHASHI SACHIMI</creator><creator>IWAO TAKAHIRO</creator><creator>MATSUNAGA TAMIHIDE</creator><creator>SUZUKI TAKAYOSHI</creator><scope>EVB</scope></search><sort><creationdate>20131212</creationdate><title>METHOD FOR INDUCING DIFFERENTIATION OF ARTIFICIAL PLURIPOTENT STEM CELL INTO HEPATOCYTE</title><author>KONDO YUKI ; MIYATA NAOKI ; YOSHIHASHI SACHIMI ; IWAO TAKAHIRO ; MATSUNAGA TAMIHIDE ; SUZUKI TAKAYOSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2013183571A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; jpn</language><creationdate>2013</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KONDO YUKI</creatorcontrib><creatorcontrib>MIYATA NAOKI</creatorcontrib><creatorcontrib>YOSHIHASHI SACHIMI</creatorcontrib><creatorcontrib>IWAO TAKAHIRO</creatorcontrib><creatorcontrib>MATSUNAGA TAMIHIDE</creatorcontrib><creatorcontrib>SUZUKI TAKAYOSHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KONDO YUKI</au><au>MIYATA NAOKI</au><au>YOSHIHASHI SACHIMI</au><au>IWAO TAKAHIRO</au><au>MATSUNAGA TAMIHIDE</au><au>SUZUKI TAKAYOSHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR INDUCING DIFFERENTIATION OF ARTIFICIAL PLURIPOTENT STEM CELL INTO HEPATOCYTE</title><date>2013-12-12</date><risdate>2013</risdate><abstract>[Problem] To provide: a novel method for inducing the differentiation of an artificial pluripotent stem cell into a hepatocyte with high efficiency; and a use of the method. [Solution] The differentiation of an artificial pluripotent stem cell into a hepatocyte can be induced through: a step of differentiating the artificial pluripotent stem cell into an endoderm-like cell; and a step of differentiating the endoderm-like cell produced in the preceding step into a hepatocyte-like cell, in which at least a part of the culturing of the endoderm-like cell is carried out in the presence of a histone deacetylase inhibitor and/or under oxidative stress-applied conditions.
L'invention concerne : un nouveau procédé d'induction de la différenciation d'une cellule souche pluripotente artificielle en un hépatocyte avec une efficacité élevée ; et une utilisation du procédé. La solution selon l'invention consiste en la différenciation d'une cellule souche pluripotente artificielle en un hépatocyte pouvant être induite par : une étape de différenciation de la cellule souche pluripotente artificielle en une cellule du type endodermique ; et une étape de différenciation de la cellule du type endodermique produite dans l'étape précédente en une cellule du type hépatocyte, au moins une partie de la culture de la cellule du type endoderme étant réalisée en présence d'un inhibiteur d'histone désacétylase et/ou par l'application de conditions de stress oxydatif.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; jpn |
| recordid | cdi_epo_espacenet_WO2013183571A1 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | METHOD FOR INDUCING DIFFERENTIATION OF ARTIFICIAL PLURIPOTENT STEM CELL INTO HEPATOCYTE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T18%3A52%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KONDO%20YUKI&rft.date=2013-12-12&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2013183571A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |