HUMANIZED PAN-HER ANTIBODY COMPOSITIONS
The invention relates to humanized recombinant antibodies targeting the EGFR family receptors EGFR, HER2 and HER3, compositions comprising at least one humanized anti-EGFR antibody, at least one humanized anti-HER2 antibody and at least one humanized anti-HER3 antibody, and use of the antibody compo...
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| creator | POULSEN, THOMAS, TUXEN ANDERSEN, PETER, SEJR PEDERSEN, MIKKEL, WANDAHL JACOBSEN, HELLE LANTTO, JOHAN KRAGH, MICHAEL KJAER, IDA STRANDH, MAGNUS KOEFOED, KLAUS NIELSEN, LARS, SOGAARD ANDERSEN, KIM, VILBOUR |
| description | The invention relates to humanized recombinant antibodies targeting the EGFR family receptors EGFR, HER2 and HER3, compositions comprising at least one humanized anti-EGFR antibody, at least one humanized anti-HER2 antibody and at least one humanized anti-HER3 antibody, and use of the antibody compositions for treatment of cancer. The invention also relates to the use of antibodies targeting multiple EGFR-family receptors to treat cancer (e.g., pancreatic cancer) and cancer that has acquired resistance to previous therapies.
La présente invention concerne des anticorps recombinés humanisés ciblant les récepteurs EGFR, HER2 et HER3 de la famille EGFR, des compositions comprenant au moins un anticorps anti-EGFR humanisé, au moins un anticorps anti-HER2 humanisé et au moins un anticorps anti-HER3 humanisé, et l'utilisation des compositions d'anticorps dans le traitement du cancer. L'invention concerne également l'utilisation d'anticorps ciblant de multiples récepteurs de la famille EGFR pour traiter un cancer (par exemple le cancer du pancréas) et un cancer ayant acquis une résistance à des thérapies précédentes. |
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La présente invention concerne des anticorps recombinés humanisés ciblant les récepteurs EGFR, HER2 et HER3 de la famille EGFR, des compositions comprenant au moins un anticorps anti-EGFR humanisé, au moins un anticorps anti-HER2 humanisé et au moins un anticorps anti-HER3 humanisé, et l'utilisation des compositions d'anticorps dans le traitement du cancer. L'invention concerne également l'utilisation d'anticorps ciblant de multiples récepteurs de la famille EGFR pour traiter un cancer (par exemple le cancer du pancréas) et un cancer ayant acquis une résistance à des thérapies précédentes.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141016&DB=EPODOC&CC=WO&NR=2013164689A8$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141016&DB=EPODOC&CC=WO&NR=2013164689A8$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>POULSEN, THOMAS, TUXEN</creatorcontrib><creatorcontrib>ANDERSEN, PETER, SEJR</creatorcontrib><creatorcontrib>PEDERSEN, MIKKEL, WANDAHL</creatorcontrib><creatorcontrib>JACOBSEN, HELLE</creatorcontrib><creatorcontrib>LANTTO, JOHAN</creatorcontrib><creatorcontrib>KRAGH, MICHAEL</creatorcontrib><creatorcontrib>KJAER, IDA</creatorcontrib><creatorcontrib>STRANDH, MAGNUS</creatorcontrib><creatorcontrib>KOEFOED, KLAUS</creatorcontrib><creatorcontrib>NIELSEN, LARS, SOGAARD</creatorcontrib><creatorcontrib>ANDERSEN, KIM, VILBOUR</creatorcontrib><title>HUMANIZED PAN-HER ANTIBODY COMPOSITIONS</title><description>The invention relates to humanized recombinant antibodies targeting the EGFR family receptors EGFR, HER2 and HER3, compositions comprising at least one humanized anti-EGFR antibody, at least one humanized anti-HER2 antibody and at least one humanized anti-HER3 antibody, and use of the antibody compositions for treatment of cancer. The invention also relates to the use of antibodies targeting multiple EGFR-family receptors to treat cancer (e.g., pancreatic cancer) and cancer that has acquired resistance to previous therapies.
La présente invention concerne des anticorps recombinés humanisés ciblant les récepteurs EGFR, HER2 et HER3 de la famille EGFR, des compositions comprenant au moins un anticorps anti-EGFR humanisé, au moins un anticorps anti-HER2 humanisé et au moins un anticorps anti-HER3 humanisé, et l'utilisation des compositions d'anticorps dans le traitement du cancer. L'invention concerne également l'utilisation d'anticorps ciblant de multiples récepteurs de la famille EGFR pour traiter un cancer (par exemple le cancer du pancréas) et un cancer ayant acquis une résistance à des thérapies précédentes.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD3CPV19POMcnVRCHD00_VwDVJw9AvxdPJ3iVRw9vcN8A_2DPH09wvmYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBobGhmYmZhaWjhbGxKkCAIk9JQ0</recordid><startdate>20141016</startdate><enddate>20141016</enddate><creator>POULSEN, THOMAS, TUXEN</creator><creator>ANDERSEN, PETER, SEJR</creator><creator>PEDERSEN, MIKKEL, WANDAHL</creator><creator>JACOBSEN, HELLE</creator><creator>LANTTO, JOHAN</creator><creator>KRAGH, MICHAEL</creator><creator>KJAER, IDA</creator><creator>STRANDH, MAGNUS</creator><creator>KOEFOED, KLAUS</creator><creator>NIELSEN, LARS, SOGAARD</creator><creator>ANDERSEN, KIM, VILBOUR</creator><scope>EVB</scope></search><sort><creationdate>20141016</creationdate><title>HUMANIZED PAN-HER ANTIBODY COMPOSITIONS</title><author>POULSEN, THOMAS, TUXEN ; ANDERSEN, PETER, SEJR ; PEDERSEN, MIKKEL, WANDAHL ; JACOBSEN, HELLE ; LANTTO, JOHAN ; KRAGH, MICHAEL ; KJAER, IDA ; STRANDH, MAGNUS ; KOEFOED, KLAUS ; NIELSEN, LARS, SOGAARD ; ANDERSEN, KIM, VILBOUR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2013164689A83</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2014</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>POULSEN, THOMAS, TUXEN</creatorcontrib><creatorcontrib>ANDERSEN, PETER, SEJR</creatorcontrib><creatorcontrib>PEDERSEN, MIKKEL, WANDAHL</creatorcontrib><creatorcontrib>JACOBSEN, HELLE</creatorcontrib><creatorcontrib>LANTTO, JOHAN</creatorcontrib><creatorcontrib>KRAGH, MICHAEL</creatorcontrib><creatorcontrib>KJAER, IDA</creatorcontrib><creatorcontrib>STRANDH, MAGNUS</creatorcontrib><creatorcontrib>KOEFOED, KLAUS</creatorcontrib><creatorcontrib>NIELSEN, LARS, SOGAARD</creatorcontrib><creatorcontrib>ANDERSEN, KIM, VILBOUR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>POULSEN, THOMAS, TUXEN</au><au>ANDERSEN, PETER, SEJR</au><au>PEDERSEN, MIKKEL, WANDAHL</au><au>JACOBSEN, HELLE</au><au>LANTTO, JOHAN</au><au>KRAGH, MICHAEL</au><au>KJAER, IDA</au><au>STRANDH, MAGNUS</au><au>KOEFOED, KLAUS</au><au>NIELSEN, LARS, SOGAARD</au><au>ANDERSEN, KIM, VILBOUR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HUMANIZED PAN-HER ANTIBODY COMPOSITIONS</title><date>2014-10-16</date><risdate>2014</risdate><abstract>The invention relates to humanized recombinant antibodies targeting the EGFR family receptors EGFR, HER2 and HER3, compositions comprising at least one humanized anti-EGFR antibody, at least one humanized anti-HER2 antibody and at least one humanized anti-HER3 antibody, and use of the antibody compositions for treatment of cancer. The invention also relates to the use of antibodies targeting multiple EGFR-family receptors to treat cancer (e.g., pancreatic cancer) and cancer that has acquired resistance to previous therapies.
La présente invention concerne des anticorps recombinés humanisés ciblant les récepteurs EGFR, HER2 et HER3 de la famille EGFR, des compositions comprenant au moins un anticorps anti-EGFR humanisé, au moins un anticorps anti-HER2 humanisé et au moins un anticorps anti-HER3 humanisé, et l'utilisation des compositions d'anticorps dans le traitement du cancer. L'invention concerne également l'utilisation d'anticorps ciblant de multiples récepteurs de la famille EGFR pour traiter un cancer (par exemple le cancer du pancréas) et un cancer ayant acquis une résistance à des thérapies précédentes.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HUMANIZED PAN-HER ANTIBODY COMPOSITIONS |
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