CELL SYSTEMS AND METHODS FOR IMPROVING FATTY ACID SYNTHESIS BY EXPRESSION OF DEHYDROGENASES
The invention relates to methods for producing lipids such as fatty acid products in recombinant host cells engineered to express a non-native gene encoding a dehydrogenase. The recombinant microorganisms are able to proliferate at a higher rate as compared with microorganisms that do not express a...
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| creator | COPPERSMITH, JENNIFER AKELLA, SRIVIDYA SESHADRI, REKHA PRAKASH, PRACHEE BROWN, ROBERT, C |
| description | The invention relates to methods for producing lipids such as fatty acid products in recombinant host cells engineered to express a non-native gene encoding a dehydrogenase. The recombinant microorganisms are able to proliferate at a higher rate as compared with microorganisms that do not express a non-native dehydrogenase gene, and cultures of microorganisms that are engineered for lipid production and that express a non-native dehydrogenase produce more lipid than cultures of control microorganisms that do not include a non-native dehydrogenase gene.
La présente invention concerne des procédés de production de lipides tels que des produits acides gras dans des cellules hôtes recombinées modifiées pour exprimer un gène non-natif codant pour une déshydrogénase. Les microorganismes recombinés sont capables de proliférer à une vitesse plus élevée par rapport à des microorganismes qui n'expriment pas de gène codant pour une déshydrogénase non-native, et les cultures des microorganismes qui sont modifiés de sorte à produire des lipides et qui expriment une déshydrogénase non-native produisent plus de lipides que les cultures de microorganismes de contrôle qui ne comprennent pas de gène codant pour une déshydrogénase non-native. |
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La présente invention concerne des procédés de production de lipides tels que des produits acides gras dans des cellules hôtes recombinées modifiées pour exprimer un gène non-natif codant pour une déshydrogénase. Les microorganismes recombinés sont capables de proliférer à une vitesse plus élevée par rapport à des microorganismes qui n'expriment pas de gène codant pour une déshydrogénase non-native, et les cultures des microorganismes qui sont modifiés de sorte à produire des lipides et qui expriment une déshydrogénase non-native produisent plus de lipides que les cultures de microorganismes de contrôle qui ne comprennent pas de gène codant pour une déshydrogénase non-native.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131031&DB=EPODOC&CC=WO&NR=2013162648A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131031&DB=EPODOC&CC=WO&NR=2013162648A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>COPPERSMITH, JENNIFER</creatorcontrib><creatorcontrib>AKELLA, SRIVIDYA</creatorcontrib><creatorcontrib>SESHADRI, REKHA</creatorcontrib><creatorcontrib>PRAKASH, PRACHEE</creatorcontrib><creatorcontrib>BROWN, ROBERT, C</creatorcontrib><title>CELL SYSTEMS AND METHODS FOR IMPROVING FATTY ACID SYNTHESIS BY EXPRESSION OF DEHYDROGENASES</title><description>The invention relates to methods for producing lipids such as fatty acid products in recombinant host cells engineered to express a non-native gene encoding a dehydrogenase. The recombinant microorganisms are able to proliferate at a higher rate as compared with microorganisms that do not express a non-native dehydrogenase gene, and cultures of microorganisms that are engineered for lipid production and that express a non-native dehydrogenase produce more lipid than cultures of control microorganisms that do not include a non-native dehydrogenase gene.
La présente invention concerne des procédés de production de lipides tels que des produits acides gras dans des cellules hôtes recombinées modifiées pour exprimer un gène non-natif codant pour une déshydrogénase. Les microorganismes recombinés sont capables de proliférer à une vitesse plus élevée par rapport à des microorganismes qui n'expriment pas de gène codant pour une déshydrogénase non-native, et les cultures des microorganismes qui sont modifiés de sorte à produire des lipides et qui expriment une déshydrogénase non-native produisent plus de lipides que les cultures de microorganismes de contrôle qui ne comprennent pas de gène codant pour une déshydrogénase non-native.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQANAuDqL-w4GzYFspXWNyaQJtruSCGhxKkTiJFur_o4Mf4PSWt8yuEtsWOHLAjkE4BR0GQ4pBkwfb9Z5O1jWgRQgRhLTqm10wyJbhGAEvvUdmSw5Ig0ITlacGnWDkdba4j485bX6usq3GIM0uTa8hzdN4S8_0Hs5U7PMyr4rqUIu8_G99AHBFM00</recordid><startdate>20131031</startdate><enddate>20131031</enddate><creator>COPPERSMITH, JENNIFER</creator><creator>AKELLA, SRIVIDYA</creator><creator>SESHADRI, REKHA</creator><creator>PRAKASH, PRACHEE</creator><creator>BROWN, ROBERT, C</creator><scope>EVB</scope></search><sort><creationdate>20131031</creationdate><title>CELL SYSTEMS AND METHODS FOR IMPROVING FATTY ACID SYNTHESIS BY EXPRESSION OF DEHYDROGENASES</title><author>COPPERSMITH, JENNIFER ; AKELLA, SRIVIDYA ; SESHADRI, REKHA ; PRAKASH, PRACHEE ; BROWN, ROBERT, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2013162648A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2013</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>COPPERSMITH, JENNIFER</creatorcontrib><creatorcontrib>AKELLA, SRIVIDYA</creatorcontrib><creatorcontrib>SESHADRI, REKHA</creatorcontrib><creatorcontrib>PRAKASH, PRACHEE</creatorcontrib><creatorcontrib>BROWN, ROBERT, C</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>COPPERSMITH, JENNIFER</au><au>AKELLA, SRIVIDYA</au><au>SESHADRI, REKHA</au><au>PRAKASH, PRACHEE</au><au>BROWN, ROBERT, C</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CELL SYSTEMS AND METHODS FOR IMPROVING FATTY ACID SYNTHESIS BY EXPRESSION OF DEHYDROGENASES</title><date>2013-10-31</date><risdate>2013</risdate><abstract>The invention relates to methods for producing lipids such as fatty acid products in recombinant host cells engineered to express a non-native gene encoding a dehydrogenase. The recombinant microorganisms are able to proliferate at a higher rate as compared with microorganisms that do not express a non-native dehydrogenase gene, and cultures of microorganisms that are engineered for lipid production and that express a non-native dehydrogenase produce more lipid than cultures of control microorganisms that do not include a non-native dehydrogenase gene.
La présente invention concerne des procédés de production de lipides tels que des produits acides gras dans des cellules hôtes recombinées modifiées pour exprimer un gène non-natif codant pour une déshydrogénase. Les microorganismes recombinés sont capables de proliférer à une vitesse plus élevée par rapport à des microorganismes qui n'expriment pas de gène codant pour une déshydrogénase non-native, et les cultures des microorganismes qui sont modifiés de sorte à produire des lipides et qui expriment une déshydrogénase non-native produisent plus de lipides que les cultures de microorganismes de contrôle qui ne comprennent pas de gène codant pour une déshydrogénase non-native.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | CELL SYSTEMS AND METHODS FOR IMPROVING FATTY ACID SYNTHESIS BY EXPRESSION OF DEHYDROGENASES |
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