ASPARTYL-TRNA SYNTHETASE-FC CONJUGATES
The present invention provides aspartyl-tRNA synthetase and Fc region conjugate polypeptides (DRS-Fc conjugates), such as DRS-Fc fusion proteins, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The DRS-Fc con...
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| creator | WU, CHI-FANG MENDLEIN, JOHN D BUECHLER, YING JI ADAMS, RYAN A WATKINS, JEFFRY D |
| description | The present invention provides aspartyl-tRNA synthetase and Fc region conjugate polypeptides (DRS-Fc conjugates), such as DRS-Fc fusion proteins, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The DRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified DRS polypeptides.
La présente invention concerne l'aspartyl-ARNt synthétase et des polypeptides conjugués à une région Fc (conjugués DRS-Fc), tels que des protéines de fusion DRS-Fc, des compositions les comprenant et des procédés d'utilisation de tels conjugués et compositions pour le traitement ou le diagnostic d'une diversité d'états de santé. Les conjugués DRS-Fc de l'invention ont amélioré les propriétés de libération contrôlée, la stabilité, la demi-vie et d'autres propriétés pharmacocinétiques et biologiques par rapport aux polypeptides de DRS non modifiés, correspondants. |
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La présente invention concerne l'aspartyl-ARNt synthétase et des polypeptides conjugués à une région Fc (conjugués DRS-Fc), tels que des protéines de fusion DRS-Fc, des compositions les comprenant et des procédés d'utilisation de tels conjugués et compositions pour le traitement ou le diagnostic d'une diversité d'états de santé. Les conjugués DRS-Fc de l'invention ont amélioré les propriétés de libération contrôlée, la stabilité, la demi-vie et d'autres propriétés pharmacocinétiques et biologiques par rapport aux polypeptides de DRS non modifiés, correspondants.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131031&DB=EPODOC&CC=WO&NR=2013115926A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131031&DB=EPODOC&CC=WO&NR=2013115926A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WU, CHI-FANG</creatorcontrib><creatorcontrib>MENDLEIN, JOHN D</creatorcontrib><creatorcontrib>BUECHLER, YING JI</creatorcontrib><creatorcontrib>ADAMS, RYAN A</creatorcontrib><creatorcontrib>WATKINS, JEFFRY D</creatorcontrib><title>ASPARTYL-TRNA SYNTHETASE-FC CONJUGATES</title><description>The present invention provides aspartyl-tRNA synthetase and Fc region conjugate polypeptides (DRS-Fc conjugates), such as DRS-Fc fusion proteins, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The DRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified DRS polypeptides.
La présente invention concerne l'aspartyl-ARNt synthétase et des polypeptides conjugués à une région Fc (conjugués DRS-Fc), tels que des protéines de fusion DRS-Fc, des compositions les comprenant et des procédés d'utilisation de tels conjugués et compositions pour le traitement ou le diagnostic d'une diversité d'états de santé. Les conjugués DRS-Fc de l'invention ont amélioré les propriétés de libération contrôlée, la stabilité, la demi-vie et d'autres propriétés pharmacocinétiques et biologiques par rapport aux polypeptides de DRS non modifiés, correspondants.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBzDA5wDAqJ9NENCfJzVAiO9AvxcA1xDHbVdXNWcPb38wp1dwxxDeZhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGhsaGhqaWRmaOxsbEqQIAcfIkwA</recordid><startdate>20131031</startdate><enddate>20131031</enddate><creator>WU, CHI-FANG</creator><creator>MENDLEIN, JOHN D</creator><creator>BUECHLER, YING JI</creator><creator>ADAMS, RYAN A</creator><creator>WATKINS, JEFFRY D</creator><scope>EVB</scope></search><sort><creationdate>20131031</creationdate><title>ASPARTYL-TRNA SYNTHETASE-FC CONJUGATES</title><author>WU, CHI-FANG ; MENDLEIN, JOHN D ; BUECHLER, YING JI ; ADAMS, RYAN A ; WATKINS, JEFFRY D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2013115926A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2013</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WU, CHI-FANG</creatorcontrib><creatorcontrib>MENDLEIN, JOHN D</creatorcontrib><creatorcontrib>BUECHLER, YING JI</creatorcontrib><creatorcontrib>ADAMS, RYAN A</creatorcontrib><creatorcontrib>WATKINS, JEFFRY D</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WU, CHI-FANG</au><au>MENDLEIN, JOHN D</au><au>BUECHLER, YING JI</au><au>ADAMS, RYAN A</au><au>WATKINS, JEFFRY D</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ASPARTYL-TRNA SYNTHETASE-FC CONJUGATES</title><date>2013-10-31</date><risdate>2013</risdate><abstract>The present invention provides aspartyl-tRNA synthetase and Fc region conjugate polypeptides (DRS-Fc conjugates), such as DRS-Fc fusion proteins, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The DRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified DRS polypeptides.
La présente invention concerne l'aspartyl-ARNt synthétase et des polypeptides conjugués à une région Fc (conjugués DRS-Fc), tels que des protéines de fusion DRS-Fc, des compositions les comprenant et des procédés d'utilisation de tels conjugués et compositions pour le traitement ou le diagnostic d'une diversité d'états de santé. Les conjugués DRS-Fc de l'invention ont amélioré les propriétés de libération contrôlée, la stabilité, la demi-vie et d'autres propriétés pharmacocinétiques et biologiques par rapport aux polypeptides de DRS non modifiés, correspondants.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | ASPARTYL-TRNA SYNTHETASE-FC CONJUGATES |
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