MEDICAMENT FOR THE TREATMENT OF CARDIAC DISEASE

The present invention relates to a medicament for the treatment of cardiac disease, especially to a medicament suitable for the treatment of myocardial disease involving myocyte hypertrophy, especially fibroblast-derived cardiac hypertrophy, e.g. heart failure, heart hypertrophy, diastolic and/or sy...

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Hauptverfasser:	THUM, THOMAS, PROF DR, BANG, CLAUDIA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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creator	THUM, THOMAS, PROF DR BANG, CLAUDIA
description	The present invention relates to a medicament for the treatment of cardiac disease, especially to a medicament suitable for the treatment of myocardial disease involving myocyte hypertrophy, especially fibroblast-derived cardiac hypertrophy, e.g. heart failure, heart hypertrophy, diastolic and/or systolic ventricular dysfunction and/or other cardiovascular diseases, where fibrosis is involved, especially aortic stenosis, atrial fibrillation, genetic forms of cardiomyopathy, cardiac storage diseases by providing an inhibitor specific for at least one of a set of microRNAs found in exosomes originating from cardiac fibroblasts for use as a medicament for human patients. La présente invention concerne un médicament destiné au traitement d'une maladie cardiaque, spécialement d'un médicament adapté au traitement d'une maladie du myocarde impliquant une hypertrophie myocytaire, spécialement une hypertrophie cardiaque fibroblastique, par exemple crise cardiaque, hypertrophie cardiaque, dysfonctionnement ventriculaire diastolique et/ou systolique et/ou d'autres maladies cardio-vasculaires impliquant une fibrose, spécialement rétrécissement aortique, fibrillation auriculaire, formes génétiques de myocardiopathie, maladies cardiaques de stockage, par l'obtention d'un inhibiteur spécifique d'au moins l'un des ensembles de microARN se trouvant dans les exosomes originaires des fibroblastes cardiaques pour emploi au titre de médicament chez des patients humains.
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subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
title	MEDICAMENT FOR THE TREATMENT OF CARDIAC DISEASE
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