SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS
Provided herein are novel substituted bicyclic aza-heterocycle sirtuin- modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example,...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | NARAYAN, RADHA VU, CHI, B OALMANN, CHRISTOPHER CASAUBON, REBECCA, L |
| description | Provided herein are novel substituted bicyclic aza-heterocycle sirtuin- modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.
L'invention concerne de nouveaux composés azahétérocycles bicycliques substitués modulateurs de la sirtuine et leurs procédés d'utilisation. Les composés modulateurs de la sirtuine peuvent servir à augmenter la durée de vie d'une cellule et à traiter et/ou prévenir une large éventail de maladies et de troubles y compris, par exemple, des maladies et des troubles associés au vieillissement ou au stress, le diabète, l'obésité, des maladies neurodégénératives, des maladies cardiovasculaires, des troubles de la coagulation sanguine, une inflammation, un cancer et/ou des bouffées vasomotrices ainsi que des maladies ou des troubles qui bénéficieraient d'une augmentation de l'activité mitochondriale. L'invention concerne également des compositions comprenant un composé modulateur de la sirtuine en combinaison avec un autre agent thérapeutique. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2013059587A9</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2013059587A9</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2013059587A93</originalsourceid><addsrcrecordid>eNrjZPAMDnUKDvEMCQ1xdVFw8nSOdPbxdFZwjHLU9XANcQ3yBwm4Bis4-rkAsaOPv3soiBesEOwZFBLq6afg6-8S6uMY4h8UzMPAmpaYU5zKC6W5GZTdXEOcPXRTC_LjU4sLEpNT81JL4sP9jQwMjQ1MLU0tzB0tjYlTBQAdvy6T</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS</title><source>esp@cenet</source><creator>NARAYAN, RADHA ; VU, CHI, B ; OALMANN, CHRISTOPHER ; CASAUBON, REBECCA, L</creator><creatorcontrib>NARAYAN, RADHA ; VU, CHI, B ; OALMANN, CHRISTOPHER ; CASAUBON, REBECCA, L</creatorcontrib><description>Provided herein are novel substituted bicyclic aza-heterocycle sirtuin- modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.
L'invention concerne de nouveaux composés azahétérocycles bicycliques substitués modulateurs de la sirtuine et leurs procédés d'utilisation. Les composés modulateurs de la sirtuine peuvent servir à augmenter la durée de vie d'une cellule et à traiter et/ou prévenir une large éventail de maladies et de troubles y compris, par exemple, des maladies et des troubles associés au vieillissement ou au stress, le diabète, l'obésité, des maladies neurodégénératives, des maladies cardiovasculaires, des troubles de la coagulation sanguine, une inflammation, un cancer et/ou des bouffées vasomotrices ainsi que des maladies ou des troubles qui bénéficieraient d'une augmentation de l'activité mitochondriale. L'invention concerne également des compositions comprenant un composé modulateur de la sirtuine en combinaison avec un autre agent thérapeutique.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141023&DB=EPODOC&CC=WO&NR=2013059587A9$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141023&DB=EPODOC&CC=WO&NR=2013059587A9$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NARAYAN, RADHA</creatorcontrib><creatorcontrib>VU, CHI, B</creatorcontrib><creatorcontrib>OALMANN, CHRISTOPHER</creatorcontrib><creatorcontrib>CASAUBON, REBECCA, L</creatorcontrib><title>SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS</title><description>Provided herein are novel substituted bicyclic aza-heterocycle sirtuin- modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.
L'invention concerne de nouveaux composés azahétérocycles bicycliques substitués modulateurs de la sirtuine et leurs procédés d'utilisation. Les composés modulateurs de la sirtuine peuvent servir à augmenter la durée de vie d'une cellule et à traiter et/ou prévenir une large éventail de maladies et de troubles y compris, par exemple, des maladies et des troubles associés au vieillissement ou au stress, le diabète, l'obésité, des maladies neurodégénératives, des maladies cardiovasculaires, des troubles de la coagulation sanguine, une inflammation, un cancer et/ou des bouffées vasomotrices ainsi que des maladies ou des troubles qui bénéficieraient d'une augmentation de l'activité mitochondriale. L'invention concerne également des compositions comprenant un composé modulateur de la sirtuine en combinaison avec un autre agent thérapeutique.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAMDnUKDvEMCQ1xdVFw8nSOdPbxdFZwjHLU9XANcQ3yBwm4Bis4-rkAsaOPv3soiBesEOwZFBLq6afg6-8S6uMY4h8UzMPAmpaYU5zKC6W5GZTdXEOcPXRTC_LjU4sLEpNT81JL4sP9jQwMjQ1MLU0tzB0tjYlTBQAdvy6T</recordid><startdate>20141023</startdate><enddate>20141023</enddate><creator>NARAYAN, RADHA</creator><creator>VU, CHI, B</creator><creator>OALMANN, CHRISTOPHER</creator><creator>CASAUBON, REBECCA, L</creator><scope>EVB</scope></search><sort><creationdate>20141023</creationdate><title>SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS</title><author>NARAYAN, RADHA ; VU, CHI, B ; OALMANN, CHRISTOPHER ; CASAUBON, REBECCA, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2013059587A93</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2014</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>NARAYAN, RADHA</creatorcontrib><creatorcontrib>VU, CHI, B</creatorcontrib><creatorcontrib>OALMANN, CHRISTOPHER</creatorcontrib><creatorcontrib>CASAUBON, REBECCA, L</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NARAYAN, RADHA</au><au>VU, CHI, B</au><au>OALMANN, CHRISTOPHER</au><au>CASAUBON, REBECCA, L</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS</title><date>2014-10-23</date><risdate>2014</risdate><abstract>Provided herein are novel substituted bicyclic aza-heterocycle sirtuin- modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.
L'invention concerne de nouveaux composés azahétérocycles bicycliques substitués modulateurs de la sirtuine et leurs procédés d'utilisation. Les composés modulateurs de la sirtuine peuvent servir à augmenter la durée de vie d'une cellule et à traiter et/ou prévenir une large éventail de maladies et de troubles y compris, par exemple, des maladies et des troubles associés au vieillissement ou au stress, le diabète, l'obésité, des maladies neurodégénératives, des maladies cardiovasculaires, des troubles de la coagulation sanguine, une inflammation, un cancer et/ou des bouffées vasomotrices ainsi que des maladies ou des troubles qui bénéficieraient d'une augmentation de l'activité mitochondriale. L'invention concerne également des compositions comprenant un composé modulateur de la sirtuine en combinaison avec un autre agent thérapeutique.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2013059587A9 |
| source | esp@cenet |
| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T14%3A57%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=NARAYAN,%20RADHA&rft.date=2014-10-23&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2013059587A9%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |