CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF

The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LEONE, GIUSEPPE, DIRUSCIO, ANNALISA, EBRALIDZE, ALEXANDER, K, TENEN, DANIEL, G
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS SUGARS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	LEONE, GIUSEPPE DIRUSCIO, ANNALISA EBRALIDZE, ALEXANDER, K TENEN, DANIEL, G
description	The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder. Cette invention concerne des oligonucléotides d'ARN chimériques qui sont des oligonucléotides simple brin. Ces composés sont capables de cibler des gènes particuliers et de réduire l'activité méthyltransférase de l'ADN. Par conséquent, ces composés sont particulièrement utiles pour traiter les maladies liées à une activité méthyltransférase aberrante de l'ADN telles que le cancer ou un trouble génétique.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2012142480A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2012142480A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2012142480A13</originalsourceid><addsrcrecordid>eNrjZNBz9vD0dQ3ydFYI8nNU8PfxdPf3C3X2cfUP8XRxDVZw9HNRCA0GMkI8XINc_d14GFjTEnOKU3mhNDeDsptriLOHbmpBfnxqcUFicmpeakl8uL-RgaGRoYmRiYWBo6ExcaoAdXAmkw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF</title><source>esp@cenet</source><creator>LEONE, GIUSEPPE ; DIRUSCIO, ANNALISA ; EBRALIDZE, ALEXANDER, K ; TENEN, DANIEL, G</creator><creatorcontrib>LEONE, GIUSEPPE ; DIRUSCIO, ANNALISA ; EBRALIDZE, ALEXANDER, K ; TENEN, DANIEL, G</creatorcontrib><description>The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder. Cette invention concerne des oligonucléotides d'ARN chimériques qui sont des oligonucléotides simple brin. Ces composés sont capables de cibler des gènes particuliers et de réduire l'activité méthyltransférase de l'ADN. Par conséquent, ces composés sont particulièrement utiles pour traiter les maladies liées à une activité méthyltransférase aberrante de l'ADN telles que le cancer ou un trouble génétique.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; DERIVATIVES THEREOF ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121018&DB=EPODOC&CC=WO&NR=2012142480A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121018&DB=EPODOC&CC=WO&NR=2012142480A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEONE, GIUSEPPE</creatorcontrib><creatorcontrib>DIRUSCIO, ANNALISA</creatorcontrib><creatorcontrib>EBRALIDZE, ALEXANDER, K</creatorcontrib><creatorcontrib>TENEN, DANIEL, G</creatorcontrib><title>CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF</title><description>The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder. Cette invention concerne des oligonucléotides d'ARN chimériques qui sont des oligonucléotides simple brin. Ces composés sont capables de cibler des gènes particuliers et de réduire l'activité méthyltransférase de l'ADN. Par conséquent, ces composés sont particulièrement utiles pour traiter les maladies liées à une activité méthyltransférase aberrante de l'ADN telles que le cancer ou un trouble génétique.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBz9vD0dQ3ydFYI8nNU8PfxdPf3C3X2cfUP8XRxDVZw9HNRCA0GMkI8XINc_d14GFjTEnOKU3mhNDeDsptriLOHbmpBfnxqcUFicmpeakl8uL-RgaGRoYmRiYWBo6ExcaoAdXAmkw</recordid><startdate>20121018</startdate><enddate>20121018</enddate><creator>LEONE, GIUSEPPE</creator><creator>DIRUSCIO, ANNALISA</creator><creator>EBRALIDZE, ALEXANDER, K</creator><creator>TENEN, DANIEL, G</creator><scope>EVB</scope></search><sort><creationdate>20121018</creationdate><title>CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF</title><author>LEONE, GIUSEPPE ; DIRUSCIO, ANNALISA ; EBRALIDZE, ALEXANDER, K ; TENEN, DANIEL, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2012142480A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2012</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LEONE, GIUSEPPE</creatorcontrib><creatorcontrib>DIRUSCIO, ANNALISA</creatorcontrib><creatorcontrib>EBRALIDZE, ALEXANDER, K</creatorcontrib><creatorcontrib>TENEN, DANIEL, G</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEONE, GIUSEPPE</au><au>DIRUSCIO, ANNALISA</au><au>EBRALIDZE, ALEXANDER, K</au><au>TENEN, DANIEL, G</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF</title><date>2012-10-18</date><risdate>2012</risdate><abstract>The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder. Cette invention concerne des oligonucléotides d'ARN chimériques qui sont des oligonucléotides simple brin. Ces composés sont capables de cibler des gènes particuliers et de réduire l'activité méthyltransférase de l'ADN. Par conséquent, ces composés sont particulièrement utiles pour traiter les maladies liées à une activité méthyltransférase aberrante de l'ADN telles que le cancer ou un trouble génétique.</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	eng ; fre
recordid	cdi_epo_espacenet_WO2012142480A1
source	esp@cenet
subjects	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS SUGARS VINEGAR WINE
title	CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T02%3A58%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=LEONE,%20GIUSEPPE&rft.date=2012-10-18&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2012142480A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true