CINNAMOMUM BURMANII EXTRACT, EXTRACTION PROCESS AND ITS USE AS PROTON PUMP DOWN-REGULATOR, ENZYME INHIBITOR, AND MUCOPROTECTOR
Extract and/or fraction from Cinnamomum burmanii (DLBS2411) related to its extraction method and its biological activities show activities as antiulcer by conferring mucoprotection and down-regulating H+/K+ ATPase. Treatment with DLBS2411 decreases the H+/K+ ATPase mRNA level in HEK 293 and gastric...
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| creator | SINAMBELA, JAMES M YULIANI, VERONIKA TJANDRAWINATA, RAYMOND, R ARIFIN, POPPY FIRZANI R. W., DEASY DIAH DWI |
| description | Extract and/or fraction from Cinnamomum burmanii (DLBS2411) related to its extraction method and its biological activities show activities as antiulcer by conferring mucoprotection and down-regulating H+/K+ ATPase. Treatment with DLBS2411 decreases the H+/K+ ATPase mRNA level in HEK 293 and gastric parietal cells. In addition, DLBS2411 inhibits activity of H+/K+ ATPase gastric enzyme wherein pH influences this inhibition mechanism. DLBS2411 also has characteristic as antioxidant which is shown by the increase of reducing power as the given dosage increases.
La présente invention concerne un extrait et/ou une fraction de Cinnamomum burmanii (DLBS2411) associés à son procédé d'extraction et ses activités biologiques présentent des activités en tant qu'anti-ulcère en conférant une mucoprotection et la régulation à la baisse de H+/K+ ATPase. Le traitement avec DLBS2411 diminue le taux d'ARNm de H+/K+ ATPase dans des cellules HEK 293 et pariétales gastriques. De plus, DLBS2411 inhibe l'activité de l'enzyme gastrique H+/K+ ATPase où le pH influence ce mécanisme d'inhibition. DLBS2411 possède également une caractéristique d'antioxydant qui est mise en évidence par l'augmentation de la réduction de pouvoir lorsque la dose administrée augmente. |
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La présente invention concerne un extrait et/ou une fraction de Cinnamomum burmanii (DLBS2411) associés à son procédé d'extraction et ses activités biologiques présentent des activités en tant qu'anti-ulcère en conférant une mucoprotection et la régulation à la baisse de H+/K+ ATPase. Le traitement avec DLBS2411 diminue le taux d'ARNm de H+/K+ ATPase dans des cellules HEK 293 et pariétales gastriques. De plus, DLBS2411 inhibe l'activité de l'enzyme gastrique H+/K+ ATPase où le pH influence ce mécanisme d'inhibition. DLBS2411 possède également une caractéristique d'antioxydant qui est mise en évidence par l'augmentation de la réduction de pouvoir lorsque la dose administrée augmente.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120913&DB=EPODOC&CC=WO&NR=2012120475A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120913&DB=EPODOC&CC=WO&NR=2012120475A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SINAMBELA, JAMES M</creatorcontrib><creatorcontrib>YULIANI, VERONIKA</creatorcontrib><creatorcontrib>TJANDRAWINATA, RAYMOND, R</creatorcontrib><creatorcontrib>ARIFIN, POPPY FIRZANI</creatorcontrib><creatorcontrib>R. W., DEASY DIAH DWI</creatorcontrib><title>CINNAMOMUM BURMANII EXTRACT, EXTRACTION PROCESS AND ITS USE AS PROTON PUMP DOWN-REGULATOR, ENZYME INHIBITOR, AND MUCOPROTECTOR</title><description>Extract and/or fraction from Cinnamomum burmanii (DLBS2411) related to its extraction method and its biological activities show activities as antiulcer by conferring mucoprotection and down-regulating H+/K+ ATPase. Treatment with DLBS2411 decreases the H+/K+ ATPase mRNA level in HEK 293 and gastric parietal cells. In addition, DLBS2411 inhibits activity of H+/K+ ATPase gastric enzyme wherein pH influences this inhibition mechanism. DLBS2411 also has characteristic as antioxidant which is shown by the increase of reducing power as the given dosage increases.
La présente invention concerne un extrait et/ou une fraction de Cinnamomum burmanii (DLBS2411) associés à son procédé d'extraction et ses activités biologiques présentent des activités en tant qu'anti-ulcère en conférant une mucoprotection et la régulation à la baisse de H+/K+ ATPase. Le traitement avec DLBS2411 diminue le taux d'ARNm de H+/K+ ATPase dans des cellules HEK 293 et pariétales gastriques. De plus, DLBS2411 inhibe l'activité de l'enzyme gastrique H+/K+ ATPase où le pH influence ce mécanisme d'inhibition. DLBS2411 possède également une caractéristique d'antioxydant qui est mise en évidence par l'augmentation de la réduction de pouvoir lorsque la dose administrée augmente.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNiz0LwjAURbs4iPofHrhaaKvFOU2jfWBeSj6oupQicRIt1NnfbiO6O93LufdMoxdHIiaVdBIKpyUjRBBHqxm3q19BRVBrxYUxwKgEtAacEcBMwDasTtZQqoZiLfbuwKzSo03nkxSAVGGBHxJk6bgKluAjmkeTa3cb_OKbs2i5E5ZXse8frR_67uLv_tk2KkvSLM2SzTZn6fq_1xstDTz6</recordid><startdate>20120913</startdate><enddate>20120913</enddate><creator>SINAMBELA, JAMES M</creator><creator>YULIANI, VERONIKA</creator><creator>TJANDRAWINATA, RAYMOND, R</creator><creator>ARIFIN, POPPY FIRZANI</creator><creator>R. W., DEASY DIAH DWI</creator><scope>EVB</scope></search><sort><creationdate>20120913</creationdate><title>CINNAMOMUM BURMANII EXTRACT, EXTRACTION PROCESS AND ITS USE AS PROTON PUMP DOWN-REGULATOR, ENZYME INHIBITOR, AND MUCOPROTECTOR</title><author>SINAMBELA, JAMES M ; YULIANI, VERONIKA ; TJANDRAWINATA, RAYMOND, R ; ARIFIN, POPPY FIRZANI ; R. W., DEASY DIAH DWI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2012120475A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2012</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SINAMBELA, JAMES M</creatorcontrib><creatorcontrib>YULIANI, VERONIKA</creatorcontrib><creatorcontrib>TJANDRAWINATA, RAYMOND, R</creatorcontrib><creatorcontrib>ARIFIN, POPPY FIRZANI</creatorcontrib><creatorcontrib>R. W., DEASY DIAH DWI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SINAMBELA, JAMES M</au><au>YULIANI, VERONIKA</au><au>TJANDRAWINATA, RAYMOND, R</au><au>ARIFIN, POPPY FIRZANI</au><au>R. W., DEASY DIAH DWI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CINNAMOMUM BURMANII EXTRACT, EXTRACTION PROCESS AND ITS USE AS PROTON PUMP DOWN-REGULATOR, ENZYME INHIBITOR, AND MUCOPROTECTOR</title><date>2012-09-13</date><risdate>2012</risdate><abstract>Extract and/or fraction from Cinnamomum burmanii (DLBS2411) related to its extraction method and its biological activities show activities as antiulcer by conferring mucoprotection and down-regulating H+/K+ ATPase. Treatment with DLBS2411 decreases the H+/K+ ATPase mRNA level in HEK 293 and gastric parietal cells. In addition, DLBS2411 inhibits activity of H+/K+ ATPase gastric enzyme wherein pH influences this inhibition mechanism. DLBS2411 also has characteristic as antioxidant which is shown by the increase of reducing power as the given dosage increases.
La présente invention concerne un extrait et/ou une fraction de Cinnamomum burmanii (DLBS2411) associés à son procédé d'extraction et ses activités biologiques présentent des activités en tant qu'anti-ulcère en conférant une mucoprotection et la régulation à la baisse de H+/K+ ATPase. Le traitement avec DLBS2411 diminue le taux d'ARNm de H+/K+ ATPase dans des cellules HEK 293 et pariétales gastriques. De plus, DLBS2411 inhibe l'activité de l'enzyme gastrique H+/K+ ATPase où le pH influence ce mécanisme d'inhibition. DLBS2411 possède également une caractéristique d'antioxydant qui est mise en évidence par l'augmentation de la réduction de pouvoir lorsque la dose administrée augmente.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CINNAMOMUM BURMANII EXTRACT, EXTRACTION PROCESS AND ITS USE AS PROTON PUMP DOWN-REGULATOR, ENZYME INHIBITOR, AND MUCOPROTECTOR |
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