GENETICALLY MODIFIED CLOSTRIDIUM THERMOCELLUM ENGINEERED TO FERMENT XYLOSE
One aspect of the invention relates to industrial bioconversion of the xylose portion of biomass materials into fuels and chemicals. Another aspect of the invention relates to industrial bioconversion of the xylan portion of biomass materials into fuels and chemicals. In one embodiment, the inventio...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | ARGYROS, AARON HOGSETT, DAVE BARRETT, TRISHA CAIAZZA, NICKY |
| description | One aspect of the invention relates to industrial bioconversion of the xylose portion of biomass materials into fuels and chemicals. Another aspect of the invention relates to industrial bioconversion of the xylan portion of biomass materials into fuels and chemicals. In one embodiment, the invention is directed to the bacterium Clostridium thermocellum, a highly cellulolytic organism that has much potential as a biocatalyst in a consolidated bioprocess configuration. In some embodiments, the invention is a genetic modification that confers the ability to ferment xylose to C. thermocellum and the strains created with this modification. In some embodiments, the genetic modification is composed of two genes contained in an operon from T. saccharolyticum. The genes express proteins with xylose isomerase (XI) and xylulokinase activites (XK). In other embodiments, the invention relates to a recombinant Clostridium thermocellum host cell capable of fermenting xylan.
Un aspect de l'invention concerne la bioconversion industrielle de la portion de xylose de matériaux de biomasse en combustibles et substances chimiques. Un autre aspect de l'invention concerne la bioconversion industrielle de la portion de xylane de matériaux de biomasse en combustibles et substances chimiques. Dans un mode de réalisation, l'invention concerne la bactérie Clostridium thermocellum, un organisme hautement cellulolytique qui a un potentiel élevé en tant que biocatalyseur dans une configuration de processus biologique consolidé. Dans certains modes de réalisation, l'invention est une modification génétique qui confère la capacité à fermenter le xylose à C. thermocellum et les souches créées avec cette modification. Dans certains modes de réalisation, la modification génétique est composée de deux gènes contenus dans un opéron de T. saccharolyticum. Les gènes expriment des protéines avec des activités xylose isomérase (XI) et xylulokinase (XK). Dans d'autres modes de réalisation, l'invention concerne une cellule hôte de Clostridium thermocellum recombinante capable de fermenter le xylane. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2012088467A3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2012088467A3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2012088467A33</originalsourceid><addsrcrecordid>eNrjZPByd_VzDfF0dvTxiVTw9XfxdPN0dVFw9vEPDgnydPEM9VUI8XAN8vV3dvXxAXJc_dw9_Vxdg4BqQvwV3IAyrn4hChGRQPWuPAysaYk5xam8UJqbQdnNNcTZQze1ID8-tbggMTk1L7UkPtzfyMDQyMDCwsTM3NHYmDhVAE4cLtE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>GENETICALLY MODIFIED CLOSTRIDIUM THERMOCELLUM ENGINEERED TO FERMENT XYLOSE</title><source>esp@cenet</source><creator>ARGYROS, AARON ; HOGSETT, DAVE ; BARRETT, TRISHA ; CAIAZZA, NICKY</creator><creatorcontrib>ARGYROS, AARON ; HOGSETT, DAVE ; BARRETT, TRISHA ; CAIAZZA, NICKY</creatorcontrib><description>One aspect of the invention relates to industrial bioconversion of the xylose portion of biomass materials into fuels and chemicals. Another aspect of the invention relates to industrial bioconversion of the xylan portion of biomass materials into fuels and chemicals. In one embodiment, the invention is directed to the bacterium Clostridium thermocellum, a highly cellulolytic organism that has much potential as a biocatalyst in a consolidated bioprocess configuration. In some embodiments, the invention is a genetic modification that confers the ability to ferment xylose to C. thermocellum and the strains created with this modification. In some embodiments, the genetic modification is composed of two genes contained in an operon from T. saccharolyticum. The genes express proteins with xylose isomerase (XI) and xylulokinase activites (XK). In other embodiments, the invention relates to a recombinant Clostridium thermocellum host cell capable of fermenting xylan.
Un aspect de l'invention concerne la bioconversion industrielle de la portion de xylose de matériaux de biomasse en combustibles et substances chimiques. Un autre aspect de l'invention concerne la bioconversion industrielle de la portion de xylane de matériaux de biomasse en combustibles et substances chimiques. Dans un mode de réalisation, l'invention concerne la bactérie Clostridium thermocellum, un organisme hautement cellulolytique qui a un potentiel élevé en tant que biocatalyseur dans une configuration de processus biologique consolidé. Dans certains modes de réalisation, l'invention est une modification génétique qui confère la capacité à fermenter le xylose à C. thermocellum et les souches créées avec cette modification. Dans certains modes de réalisation, la modification génétique est composée de deux gènes contenus dans un opéron de T. saccharolyticum. Les gènes expriment des protéines avec des activités xylose isomérase (XI) et xylulokinase (XK). Dans d'autres modes de réalisation, l'invention concerne une cellule hôte de Clostridium thermocellum recombinante capable de fermenter le xylane.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121026&DB=EPODOC&CC=WO&NR=2012088467A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121026&DB=EPODOC&CC=WO&NR=2012088467A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ARGYROS, AARON</creatorcontrib><creatorcontrib>HOGSETT, DAVE</creatorcontrib><creatorcontrib>BARRETT, TRISHA</creatorcontrib><creatorcontrib>CAIAZZA, NICKY</creatorcontrib><title>GENETICALLY MODIFIED CLOSTRIDIUM THERMOCELLUM ENGINEERED TO FERMENT XYLOSE</title><description>One aspect of the invention relates to industrial bioconversion of the xylose portion of biomass materials into fuels and chemicals. Another aspect of the invention relates to industrial bioconversion of the xylan portion of biomass materials into fuels and chemicals. In one embodiment, the invention is directed to the bacterium Clostridium thermocellum, a highly cellulolytic organism that has much potential as a biocatalyst in a consolidated bioprocess configuration. In some embodiments, the invention is a genetic modification that confers the ability to ferment xylose to C. thermocellum and the strains created with this modification. In some embodiments, the genetic modification is composed of two genes contained in an operon from T. saccharolyticum. The genes express proteins with xylose isomerase (XI) and xylulokinase activites (XK). In other embodiments, the invention relates to a recombinant Clostridium thermocellum host cell capable of fermenting xylan.
Un aspect de l'invention concerne la bioconversion industrielle de la portion de xylose de matériaux de biomasse en combustibles et substances chimiques. Un autre aspect de l'invention concerne la bioconversion industrielle de la portion de xylane de matériaux de biomasse en combustibles et substances chimiques. Dans un mode de réalisation, l'invention concerne la bactérie Clostridium thermocellum, un organisme hautement cellulolytique qui a un potentiel élevé en tant que biocatalyseur dans une configuration de processus biologique consolidé. Dans certains modes de réalisation, l'invention est une modification génétique qui confère la capacité à fermenter le xylose à C. thermocellum et les souches créées avec cette modification. Dans certains modes de réalisation, la modification génétique est composée de deux gènes contenus dans un opéron de T. saccharolyticum. Les gènes expriment des protéines avec des activités xylose isomérase (XI) et xylulokinase (XK). Dans d'autres modes de réalisation, l'invention concerne une cellule hôte de Clostridium thermocellum recombinante capable de fermenter le xylane.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPByd_VzDfF0dvTxiVTw9XfxdPN0dVFw9vEPDgnydPEM9VUI8XAN8vV3dvXxAXJc_dw9_Vxdg4BqQvwV3IAyrn4hChGRQPWuPAysaYk5xam8UJqbQdnNNcTZQze1ID8-tbggMTk1L7UkPtzfyMDQyMDCwsTM3NHYmDhVAE4cLtE</recordid><startdate>20121026</startdate><enddate>20121026</enddate><creator>ARGYROS, AARON</creator><creator>HOGSETT, DAVE</creator><creator>BARRETT, TRISHA</creator><creator>CAIAZZA, NICKY</creator><scope>EVB</scope></search><sort><creationdate>20121026</creationdate><title>GENETICALLY MODIFIED CLOSTRIDIUM THERMOCELLUM ENGINEERED TO FERMENT XYLOSE</title><author>ARGYROS, AARON ; HOGSETT, DAVE ; BARRETT, TRISHA ; CAIAZZA, NICKY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2012088467A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2012</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>ARGYROS, AARON</creatorcontrib><creatorcontrib>HOGSETT, DAVE</creatorcontrib><creatorcontrib>BARRETT, TRISHA</creatorcontrib><creatorcontrib>CAIAZZA, NICKY</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ARGYROS, AARON</au><au>HOGSETT, DAVE</au><au>BARRETT, TRISHA</au><au>CAIAZZA, NICKY</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>GENETICALLY MODIFIED CLOSTRIDIUM THERMOCELLUM ENGINEERED TO FERMENT XYLOSE</title><date>2012-10-26</date><risdate>2012</risdate><abstract>One aspect of the invention relates to industrial bioconversion of the xylose portion of biomass materials into fuels and chemicals. Another aspect of the invention relates to industrial bioconversion of the xylan portion of biomass materials into fuels and chemicals. In one embodiment, the invention is directed to the bacterium Clostridium thermocellum, a highly cellulolytic organism that has much potential as a biocatalyst in a consolidated bioprocess configuration. In some embodiments, the invention is a genetic modification that confers the ability to ferment xylose to C. thermocellum and the strains created with this modification. In some embodiments, the genetic modification is composed of two genes contained in an operon from T. saccharolyticum. The genes express proteins with xylose isomerase (XI) and xylulokinase activites (XK). In other embodiments, the invention relates to a recombinant Clostridium thermocellum host cell capable of fermenting xylan.
Un aspect de l'invention concerne la bioconversion industrielle de la portion de xylose de matériaux de biomasse en combustibles et substances chimiques. Un autre aspect de l'invention concerne la bioconversion industrielle de la portion de xylane de matériaux de biomasse en combustibles et substances chimiques. Dans un mode de réalisation, l'invention concerne la bactérie Clostridium thermocellum, un organisme hautement cellulolytique qui a un potentiel élevé en tant que biocatalyseur dans une configuration de processus biologique consolidé. Dans certains modes de réalisation, l'invention est une modification génétique qui confère la capacité à fermenter le xylose à C. thermocellum et les souches créées avec cette modification. Dans certains modes de réalisation, la modification génétique est composée de deux gènes contenus dans un opéron de T. saccharolyticum. Les gènes expriment des protéines avec des activités xylose isomérase (XI) et xylulokinase (XK). Dans d'autres modes de réalisation, l'invention concerne une cellule hôte de Clostridium thermocellum recombinante capable de fermenter le xylane.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_WO2012088467A3 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | GENETICALLY MODIFIED CLOSTRIDIUM THERMOCELLUM ENGINEERED TO FERMENT XYLOSE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T20%3A43%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ARGYROS,%20AARON&rft.date=2012-10-26&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2012088467A3%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |