EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT
A new method for the synthesis of L-Glutamyl-?-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8- tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido) butanamido)pentanedioic acid, 1 are provided. Also provided is...
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| creator | DALZIEL, SEAN, MARK JACKS, THOMAS, ELLIOTT THOMPSON, ANDREW, S ZELLER, JAMES, ROBERT CHOUBAL, MILIND, D KERSCHEN, JAMES, ALAN BRIDGES, ALEXANDER, JAMES |
| description | A new method for the synthesis of L-Glutamyl-?-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8- tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido) butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.
L'invention concerne un nouveau procédé pour la synthèse d'acide L-glutamyl-?-D-glutamique et son utilisation dans la synthèse d'acide (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxyméthyl)-4-oxo-3,4,7,8-tétrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioïque, 1. L'invention concerne également un procédé efficace pour l'isolement et la purification du sel trisodique de l'acide mentionné ci-dessus, 2, dans une forme adaptée pour un stockage à long terme et une utilisation dans une forme posologique parentérale. |
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L'invention concerne un nouveau procédé pour la synthèse d'acide L-glutamyl-?-D-glutamique et son utilisation dans la synthèse d'acide (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxyméthyl)-4-oxo-3,4,7,8-tétrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioïque, 1. L'invention concerne également un procédé efficace pour l'isolement et la purification du sel trisodique de l'acide mentionné ci-dessus, 2, dans une forme adaptée pour un stockage à long terme et une utilisation dans une forme posologique parentérale.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120628&DB=EPODOC&CC=WO&NR=2012087888A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25566,76549</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120628&DB=EPODOC&CC=WO&NR=2012087888A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DALZIEL, SEAN, MARK</creatorcontrib><creatorcontrib>JACKS, THOMAS, ELLIOTT</creatorcontrib><creatorcontrib>THOMPSON, ANDREW, S</creatorcontrib><creatorcontrib>ZELLER, JAMES, ROBERT</creatorcontrib><creatorcontrib>CHOUBAL, MILIND, D</creatorcontrib><creatorcontrib>KERSCHEN, JAMES, ALAN</creatorcontrib><creatorcontrib>BRIDGES, ALEXANDER, JAMES</creatorcontrib><title>EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT</title><description>A new method for the synthesis of L-Glutamyl-?-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8- tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido) butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.
L'invention concerne un nouveau procédé pour la synthèse d'acide L-glutamyl-?-D-glutamique et son utilisation dans la synthèse d'acide (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxyméthyl)-4-oxo-3,4,7,8-tétrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioïque, 1. L'invention concerne également un procédé efficace pour l'isolement et la purification du sel trisodique de l'acide mentionné ci-dessus, 2, dans une forme adaptée pour un stockage à long terme et une utilisation dans une forme posologique parentérale.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLEKwjAURbs4iPoPD1x0EGodzBrSl_ZBTGKTIHUpReIkWqjg7xvRD3A6XO7hTLMXSkmCUHuwaD2VCMIEq0hXDrguwddIDQSHQPozwLU6wdH3JmcU92Q0GAkcRCuUsanGYVWt4RhI87NJNQTfJLekcADHlZ9nk2t_G-Pix1m2lOhFvYnDo4vj0F_iPT67kynybZGzPWOMF7v_rDcb-Dp6</recordid><startdate>20120628</startdate><enddate>20120628</enddate><creator>DALZIEL, SEAN, MARK</creator><creator>JACKS, THOMAS, ELLIOTT</creator><creator>THOMPSON, ANDREW, S</creator><creator>ZELLER, JAMES, ROBERT</creator><creator>CHOUBAL, MILIND, D</creator><creator>KERSCHEN, JAMES, ALAN</creator><creator>BRIDGES, ALEXANDER, JAMES</creator><scope>EVB</scope></search><sort><creationdate>20120628</creationdate><title>EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT</title><author>DALZIEL, SEAN, MARK ; JACKS, THOMAS, ELLIOTT ; THOMPSON, ANDREW, S ; ZELLER, JAMES, ROBERT ; CHOUBAL, MILIND, D ; KERSCHEN, JAMES, ALAN ; BRIDGES, ALEXANDER, JAMES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2012087888A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2012</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><toplevel>online_resources</toplevel><creatorcontrib>DALZIEL, SEAN, MARK</creatorcontrib><creatorcontrib>JACKS, THOMAS, ELLIOTT</creatorcontrib><creatorcontrib>THOMPSON, ANDREW, S</creatorcontrib><creatorcontrib>ZELLER, JAMES, ROBERT</creatorcontrib><creatorcontrib>CHOUBAL, MILIND, D</creatorcontrib><creatorcontrib>KERSCHEN, JAMES, ALAN</creatorcontrib><creatorcontrib>BRIDGES, ALEXANDER, JAMES</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DALZIEL, SEAN, MARK</au><au>JACKS, THOMAS, ELLIOTT</au><au>THOMPSON, ANDREW, S</au><au>ZELLER, JAMES, ROBERT</au><au>CHOUBAL, MILIND, D</au><au>KERSCHEN, JAMES, ALAN</au><au>BRIDGES, ALEXANDER, JAMES</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT</title><date>2012-06-28</date><risdate>2012</risdate><abstract>A new method for the synthesis of L-Glutamyl-?-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8- tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido) butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.
L'invention concerne un nouveau procédé pour la synthèse d'acide L-glutamyl-?-D-glutamique et son utilisation dans la synthèse d'acide (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxyméthyl)-4-oxo-3,4,7,8-tétrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioïque, 1. L'invention concerne également un procédé efficace pour l'isolement et la purification du sel trisodique de l'acide mentionné ci-dessus, 2, dans une forme adaptée pour un stockage à long terme et une utilisation dans une forme posologique parentérale.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PEPTIDES |
| title | EFFICIENT PEPTIDE COUPLINGS AND THEIR USE IN THE SYNTHESIS AND ISOLATION OF A CYCLOPENTA (G) QUINAZOLINE TRISODIUM SALT |
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