ANTI-NGF COMPOSITIONS AND USE THEREOF
The present invention is directed to antibodies and fragments thereof having binding specificity for NGF, especially those that inhibit the interaction of NGF with TrkA and/or p75 or p75 and/or TrkA. Another embodiment of this invention relates to the antibodies described herein, and binding fragmen...
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| creator | OJALA, ETHAN W MCNEILL, PATRICIA DIANNE FAN, PEI GARCIA-MARTINEZ, LEON F LATHAM, JOHN A AKATSUKA, CORINNE C MITCHELL, DANIELLE M STEWART, ERICA A DUTZAR, BENJAMIN H BILLGREN, JENS CHANG, BETTY YUING SMITH, JEFFREY T.L KOVACEVICH, BRIAN R |
| description | The present invention is directed to antibodies and fragments thereof having binding specificity for NGF, especially those that inhibit the interaction of NGF with TrkA and/or p75 or p75 and/or TrkA. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
La présente invention concerne des anticorps et leurs fragments qui possèdent une spécificité de liaison avec le NGF, en particulier ceux qui inhibent l'interaction du NGF avec le TrkA et/ou le p75 ou le p75 et/ou le TrkA. Dans un autre mode de réalisation, l'invention porte sur les anticorps décrits ici, et sur leurs fragments de liaison, comprenant les séquences des polypeptides VH, VL et CDR décrits ici, et sur les polynucléotides codant pour ceux-ci. L'invention a également trait à des conjugués d'anticorps anti-NGF et à leurs fragments de liaison conjugués à une ou plusieurs fractions fonctionnelles ou détectables. L'invention concerne en outre des procédés de préparation desdits anticorps anti-NGF et de leurs fragments de liaison. Dans certains modes de réalisation, l'invention porte également sur l'utilisation des anticorps anti-NGF, et sur leurs fragments de liaison, pour le diagnostic, l'évaluation et le traitement de maladies et de troubles associés au NGF. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2012075340A2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2012075340A2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2012075340A23</originalsourceid><addsrcrecordid>eNrjZFB19Avx1PVzd1Nw9vcN8A_2DPH09wtWcPRzUQgNdlUI8XANcvV342FgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgaGRgbmpsYmBo5GxsSpAgAlpyQW</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>ANTI-NGF COMPOSITIONS AND USE THEREOF</title><source>esp@cenet</source><creator>OJALA, ETHAN W ; MCNEILL, PATRICIA DIANNE ; FAN, PEI ; GARCIA-MARTINEZ, LEON F ; LATHAM, JOHN A ; AKATSUKA, CORINNE C ; MITCHELL, DANIELLE M ; STEWART, ERICA A ; DUTZAR, BENJAMIN H ; BILLGREN, JENS ; CHANG, BETTY YUING ; SMITH, JEFFREY T.L ; KOVACEVICH, BRIAN R</creator><creatorcontrib>OJALA, ETHAN W ; MCNEILL, PATRICIA DIANNE ; FAN, PEI ; GARCIA-MARTINEZ, LEON F ; LATHAM, JOHN A ; AKATSUKA, CORINNE C ; MITCHELL, DANIELLE M ; STEWART, ERICA A ; DUTZAR, BENJAMIN H ; BILLGREN, JENS ; CHANG, BETTY YUING ; SMITH, JEFFREY T.L ; KOVACEVICH, BRIAN R</creatorcontrib><description>The present invention is directed to antibodies and fragments thereof having binding specificity for NGF, especially those that inhibit the interaction of NGF with TrkA and/or p75 or p75 and/or TrkA. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
La présente invention concerne des anticorps et leurs fragments qui possèdent une spécificité de liaison avec le NGF, en particulier ceux qui inhibent l'interaction du NGF avec le TrkA et/ou le p75 ou le p75 et/ou le TrkA. Dans un autre mode de réalisation, l'invention porte sur les anticorps décrits ici, et sur leurs fragments de liaison, comprenant les séquences des polypeptides VH, VL et CDR décrits ici, et sur les polynucléotides codant pour ceux-ci. L'invention a également trait à des conjugués d'anticorps anti-NGF et à leurs fragments de liaison conjugués à une ou plusieurs fractions fonctionnelles ou détectables. L'invention concerne en outre des procédés de préparation desdits anticorps anti-NGF et de leurs fragments de liaison. Dans certains modes de réalisation, l'invention porte également sur l'utilisation des anticorps anti-NGF, et sur leurs fragments de liaison, pour le diagnostic, l'évaluation et le traitement de maladies et de troubles associés au NGF.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120607&DB=EPODOC&CC=WO&NR=2012075340A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120607&DB=EPODOC&CC=WO&NR=2012075340A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OJALA, ETHAN W</creatorcontrib><creatorcontrib>MCNEILL, PATRICIA DIANNE</creatorcontrib><creatorcontrib>FAN, PEI</creatorcontrib><creatorcontrib>GARCIA-MARTINEZ, LEON F</creatorcontrib><creatorcontrib>LATHAM, JOHN A</creatorcontrib><creatorcontrib>AKATSUKA, CORINNE C</creatorcontrib><creatorcontrib>MITCHELL, DANIELLE M</creatorcontrib><creatorcontrib>STEWART, ERICA A</creatorcontrib><creatorcontrib>DUTZAR, BENJAMIN H</creatorcontrib><creatorcontrib>BILLGREN, JENS</creatorcontrib><creatorcontrib>CHANG, BETTY YUING</creatorcontrib><creatorcontrib>SMITH, JEFFREY T.L</creatorcontrib><creatorcontrib>KOVACEVICH, BRIAN R</creatorcontrib><title>ANTI-NGF COMPOSITIONS AND USE THEREOF</title><description>The present invention is directed to antibodies and fragments thereof having binding specificity for NGF, especially those that inhibit the interaction of NGF with TrkA and/or p75 or p75 and/or TrkA. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
La présente invention concerne des anticorps et leurs fragments qui possèdent une spécificité de liaison avec le NGF, en particulier ceux qui inhibent l'interaction du NGF avec le TrkA et/ou le p75 ou le p75 et/ou le TrkA. Dans un autre mode de réalisation, l'invention porte sur les anticorps décrits ici, et sur leurs fragments de liaison, comprenant les séquences des polypeptides VH, VL et CDR décrits ici, et sur les polynucléotides codant pour ceux-ci. L'invention a également trait à des conjugués d'anticorps anti-NGF et à leurs fragments de liaison conjugués à une ou plusieurs fractions fonctionnelles ou détectables. L'invention concerne en outre des procédés de préparation desdits anticorps anti-NGF et de leurs fragments de liaison. Dans certains modes de réalisation, l'invention porte également sur l'utilisation des anticorps anti-NGF, et sur leurs fragments de liaison, pour le diagnostic, l'évaluation et le traitement de maladies et de troubles associés au NGF.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB19Avx1PVzd1Nw9vcN8A_2DPH09wtWcPRzUQgNdlUI8XANcvV342FgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgaGRgbmpsYmBo5GxsSpAgAlpyQW</recordid><startdate>20120607</startdate><enddate>20120607</enddate><creator>OJALA, ETHAN W</creator><creator>MCNEILL, PATRICIA DIANNE</creator><creator>FAN, PEI</creator><creator>GARCIA-MARTINEZ, LEON F</creator><creator>LATHAM, JOHN A</creator><creator>AKATSUKA, CORINNE C</creator><creator>MITCHELL, DANIELLE M</creator><creator>STEWART, ERICA A</creator><creator>DUTZAR, BENJAMIN H</creator><creator>BILLGREN, JENS</creator><creator>CHANG, BETTY YUING</creator><creator>SMITH, JEFFREY T.L</creator><creator>KOVACEVICH, BRIAN R</creator><scope>EVB</scope></search><sort><creationdate>20120607</creationdate><title>ANTI-NGF COMPOSITIONS AND USE THEREOF</title><author>OJALA, ETHAN W ; MCNEILL, PATRICIA DIANNE ; FAN, PEI ; GARCIA-MARTINEZ, LEON F ; LATHAM, JOHN A ; AKATSUKA, CORINNE C ; MITCHELL, DANIELLE M ; STEWART, ERICA A ; DUTZAR, BENJAMIN H ; BILLGREN, JENS ; CHANG, BETTY YUING ; SMITH, JEFFREY T.L ; KOVACEVICH, BRIAN R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2012075340A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2012</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>OJALA, ETHAN W</creatorcontrib><creatorcontrib>MCNEILL, PATRICIA DIANNE</creatorcontrib><creatorcontrib>FAN, PEI</creatorcontrib><creatorcontrib>GARCIA-MARTINEZ, LEON F</creatorcontrib><creatorcontrib>LATHAM, JOHN A</creatorcontrib><creatorcontrib>AKATSUKA, CORINNE C</creatorcontrib><creatorcontrib>MITCHELL, DANIELLE M</creatorcontrib><creatorcontrib>STEWART, ERICA A</creatorcontrib><creatorcontrib>DUTZAR, BENJAMIN H</creatorcontrib><creatorcontrib>BILLGREN, JENS</creatorcontrib><creatorcontrib>CHANG, BETTY YUING</creatorcontrib><creatorcontrib>SMITH, JEFFREY T.L</creatorcontrib><creatorcontrib>KOVACEVICH, BRIAN R</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OJALA, ETHAN W</au><au>MCNEILL, PATRICIA DIANNE</au><au>FAN, PEI</au><au>GARCIA-MARTINEZ, LEON F</au><au>LATHAM, JOHN A</au><au>AKATSUKA, CORINNE C</au><au>MITCHELL, DANIELLE M</au><au>STEWART, ERICA A</au><au>DUTZAR, BENJAMIN H</au><au>BILLGREN, JENS</au><au>CHANG, BETTY YUING</au><au>SMITH, JEFFREY T.L</au><au>KOVACEVICH, BRIAN R</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTI-NGF COMPOSITIONS AND USE THEREOF</title><date>2012-06-07</date><risdate>2012</risdate><abstract>The present invention is directed to antibodies and fragments thereof having binding specificity for NGF, especially those that inhibit the interaction of NGF with TrkA and/or p75 or p75 and/or TrkA. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
La présente invention concerne des anticorps et leurs fragments qui possèdent une spécificité de liaison avec le NGF, en particulier ceux qui inhibent l'interaction du NGF avec le TrkA et/ou le p75 ou le p75 et/ou le TrkA. Dans un autre mode de réalisation, l'invention porte sur les anticorps décrits ici, et sur leurs fragments de liaison, comprenant les séquences des polypeptides VH, VL et CDR décrits ici, et sur les polynucléotides codant pour ceux-ci. L'invention a également trait à des conjugués d'anticorps anti-NGF et à leurs fragments de liaison conjugués à une ou plusieurs fractions fonctionnelles ou détectables. L'invention concerne en outre des procédés de préparation desdits anticorps anti-NGF et de leurs fragments de liaison. Dans certains modes de réalisation, l'invention porte également sur l'utilisation des anticorps anti-NGF, et sur leurs fragments de liaison, pour le diagnostic, l'évaluation et le traitement de maladies et de troubles associés au NGF.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | ANTI-NGF COMPOSITIONS AND USE THEREOF |
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