INHIBITORS OF POLO-LIKE KINASE
The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making a...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | ARTIS, DEAN, RICHARD YE, XIAOCONG, MICHAEL AUBELE, DANIELLE, L ADLER, MARC ZHU, YONG-LIANG BEROZA, PAUL GALEMMO, ROBERT, A HOM, ROY, K NEITZ, R., JEFFREY BOWERS, SIMEON SEALY, JENNIFER TROUNG, ANH, P ANDERSON, JOHN, P |
| description | The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
La présente invention concerne des composés ayant une structure selon la Formule (I): ou un sel ou solvate de celui-ci, où le cycle A, U1, U2, U3, R2, R3 et R4 sont définis dans la présente. L'invention concerne en plus des compositions pharmaceutiques incluant les composés de l'invention et des procédés de fabrication et d'utilisation des composés et des compositions de l'invention, par exemple, dans le traitement et la prévention de diverses maladies, comme la maladie de Parkinson. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2012048129A3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2012048129A3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2012048129A33</originalsourceid><addsrcrecordid>eNrjZJDz9PPwdPIM8Q8KVvB3Uwjw9_HX9fH0dlXw9vRzDHblYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBoZGBiYWhkaWjsbGxKkCAC8TIio</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>INHIBITORS OF POLO-LIKE KINASE</title><source>esp@cenet</source><creator>ARTIS, DEAN, RICHARD ; YE, XIAOCONG, MICHAEL ; AUBELE, DANIELLE, L ; ADLER, MARC ; ZHU, YONG-LIANG ; BEROZA, PAUL ; GALEMMO, ROBERT, A ; HOM, ROY, K ; NEITZ, R., JEFFREY ; BOWERS, SIMEON ; SEALY, JENNIFER ; TROUNG, ANH, P ; ANDERSON, JOHN, P</creator><creatorcontrib>ARTIS, DEAN, RICHARD ; YE, XIAOCONG, MICHAEL ; AUBELE, DANIELLE, L ; ADLER, MARC ; ZHU, YONG-LIANG ; BEROZA, PAUL ; GALEMMO, ROBERT, A ; HOM, ROY, K ; NEITZ, R., JEFFREY ; BOWERS, SIMEON ; SEALY, JENNIFER ; TROUNG, ANH, P ; ANDERSON, JOHN, P</creatorcontrib><description>The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
La présente invention concerne des composés ayant une structure selon la Formule (I): ou un sel ou solvate de celui-ci, où le cycle A, U1, U2, U3, R2, R3 et R4 sont définis dans la présente. L'invention concerne en plus des compositions pharmaceutiques incluant les composés de l'invention et des procédés de fabrication et d'utilisation des composés et des compositions de l'invention, par exemple, dans le traitement et la prévention de diverses maladies, comme la maladie de Parkinson.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120726&DB=EPODOC&CC=WO&NR=2012048129A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120726&DB=EPODOC&CC=WO&NR=2012048129A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ARTIS, DEAN, RICHARD</creatorcontrib><creatorcontrib>YE, XIAOCONG, MICHAEL</creatorcontrib><creatorcontrib>AUBELE, DANIELLE, L</creatorcontrib><creatorcontrib>ADLER, MARC</creatorcontrib><creatorcontrib>ZHU, YONG-LIANG</creatorcontrib><creatorcontrib>BEROZA, PAUL</creatorcontrib><creatorcontrib>GALEMMO, ROBERT, A</creatorcontrib><creatorcontrib>HOM, ROY, K</creatorcontrib><creatorcontrib>NEITZ, R., JEFFREY</creatorcontrib><creatorcontrib>BOWERS, SIMEON</creatorcontrib><creatorcontrib>SEALY, JENNIFER</creatorcontrib><creatorcontrib>TROUNG, ANH, P</creatorcontrib><creatorcontrib>ANDERSON, JOHN, P</creatorcontrib><title>INHIBITORS OF POLO-LIKE KINASE</title><description>The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
La présente invention concerne des composés ayant une structure selon la Formule (I): ou un sel ou solvate de celui-ci, où le cycle A, U1, U2, U3, R2, R3 et R4 sont définis dans la présente. L'invention concerne en plus des compositions pharmaceutiques incluant les composés de l'invention et des procédés de fabrication et d'utilisation des composés et des compositions de l'invention, par exemple, dans le traitement et la prévention de diverses maladies, comme la maladie de Parkinson.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJDz9PPwdPIM8Q8KVvB3Uwjw9_HX9fH0dlXw9vRzDHblYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBoZGBiYWhkaWjsbGxKkCAC8TIio</recordid><startdate>20120726</startdate><enddate>20120726</enddate><creator>ARTIS, DEAN, RICHARD</creator><creator>YE, XIAOCONG, MICHAEL</creator><creator>AUBELE, DANIELLE, L</creator><creator>ADLER, MARC</creator><creator>ZHU, YONG-LIANG</creator><creator>BEROZA, PAUL</creator><creator>GALEMMO, ROBERT, A</creator><creator>HOM, ROY, K</creator><creator>NEITZ, R., JEFFREY</creator><creator>BOWERS, SIMEON</creator><creator>SEALY, JENNIFER</creator><creator>TROUNG, ANH, P</creator><creator>ANDERSON, JOHN, P</creator><scope>EVB</scope></search><sort><creationdate>20120726</creationdate><title>INHIBITORS OF POLO-LIKE KINASE</title><author>ARTIS, DEAN, RICHARD ; YE, XIAOCONG, MICHAEL ; AUBELE, DANIELLE, L ; ADLER, MARC ; ZHU, YONG-LIANG ; BEROZA, PAUL ; GALEMMO, ROBERT, A ; HOM, ROY, K ; NEITZ, R., JEFFREY ; BOWERS, SIMEON ; SEALY, JENNIFER ; TROUNG, ANH, P ; ANDERSON, JOHN, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2012048129A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2012</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ARTIS, DEAN, RICHARD</creatorcontrib><creatorcontrib>YE, XIAOCONG, MICHAEL</creatorcontrib><creatorcontrib>AUBELE, DANIELLE, L</creatorcontrib><creatorcontrib>ADLER, MARC</creatorcontrib><creatorcontrib>ZHU, YONG-LIANG</creatorcontrib><creatorcontrib>BEROZA, PAUL</creatorcontrib><creatorcontrib>GALEMMO, ROBERT, A</creatorcontrib><creatorcontrib>HOM, ROY, K</creatorcontrib><creatorcontrib>NEITZ, R., JEFFREY</creatorcontrib><creatorcontrib>BOWERS, SIMEON</creatorcontrib><creatorcontrib>SEALY, JENNIFER</creatorcontrib><creatorcontrib>TROUNG, ANH, P</creatorcontrib><creatorcontrib>ANDERSON, JOHN, P</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ARTIS, DEAN, RICHARD</au><au>YE, XIAOCONG, MICHAEL</au><au>AUBELE, DANIELLE, L</au><au>ADLER, MARC</au><au>ZHU, YONG-LIANG</au><au>BEROZA, PAUL</au><au>GALEMMO, ROBERT, A</au><au>HOM, ROY, K</au><au>NEITZ, R., JEFFREY</au><au>BOWERS, SIMEON</au><au>SEALY, JENNIFER</au><au>TROUNG, ANH, P</au><au>ANDERSON, JOHN, P</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INHIBITORS OF POLO-LIKE KINASE</title><date>2012-07-26</date><risdate>2012</risdate><abstract>The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, U1, U2, U3, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
La présente invention concerne des composés ayant une structure selon la Formule (I): ou un sel ou solvate de celui-ci, où le cycle A, U1, U2, U3, R2, R3 et R4 sont définis dans la présente. L'invention concerne en plus des compositions pharmaceutiques incluant les composés de l'invention et des procédés de fabrication et d'utilisation des composés et des compositions de l'invention, par exemple, dans le traitement et la prévention de diverses maladies, comme la maladie de Parkinson.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2012048129A3 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | INHIBITORS OF POLO-LIKE KINASE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T10%3A43%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ARTIS,%20DEAN,%20RICHARD&rft.date=2012-07-26&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2012048129A3%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |