PROCESS FOR THE PREPARATION OF AMINO ACID DERIVATIVES
The present invention relates to a process of manufacture of compounds of formula (B) wherein R1, R2 and R3 are as defined for compounds of formula (A), which process comprises hydrogenation of compounds of general formula (A). In particular, the present invention relates to an improved process for...
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| creator | MERSCHAERT, ALAIN BOUVY, DIDIER VASSELIN, DAVID CARLY, NICOLAS |
| description | The present invention relates to a process of manufacture of compounds of formula (B) wherein R1, R2 and R3 are as defined for compounds of formula (A), which process comprises hydrogenation of compounds of general formula (A). In particular, the present invention relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (B1), which is useful as an anticonvulsive drug.
La présente invention concerne un procédé de fabrication de composés de formule (B) où R1, R2 et R3 sont tels que définis pour les composés de formule (A), ledit procédé comprenant l'hydrogénation de composés de formule générale (A). En particulier, la présente invention concerne un procédé amélioré de fabrication de Lacosamide (LCM), (R)-2-acétamido-N-benzyl-3-méthoxypropion-amide (B1), pouvant être employé en tant que médicament antiépileptique. |
| format | Patent |
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La présente invention concerne un procédé de fabrication de composés de formule (B) où R1, R2 et R3 sont tels que définis pour les composés de formule (A), ledit procédé comprenant l'hydrogénation de composés de formule générale (A). En particulier, la présente invention concerne un procédé amélioré de fabrication de Lacosamide (LCM), (R)-2-acétamido-N-benzyl-3-méthoxypropion-amide (B1), pouvant être employé en tant que médicament antiépileptique.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120405&DB=EPODOC&CC=WO&NR=2012041986A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120405&DB=EPODOC&CC=WO&NR=2012041986A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MERSCHAERT, ALAIN</creatorcontrib><creatorcontrib>BOUVY, DIDIER</creatorcontrib><creatorcontrib>VASSELIN, DAVID</creatorcontrib><creatorcontrib>CARLY, NICOLAS</creatorcontrib><title>PROCESS FOR THE PREPARATION OF AMINO ACID DERIVATIVES</title><description>The present invention relates to a process of manufacture of compounds of formula (B) wherein R1, R2 and R3 are as defined for compounds of formula (A), which process comprises hydrogenation of compounds of general formula (A). In particular, the present invention relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (B1), which is useful as an anticonvulsive drug.
La présente invention concerne un procédé de fabrication de composés de formule (B) où R1, R2 et R3 sont tels que définis pour les composés de formule (A), ledit procédé comprenant l'hydrogénation de composés de formule générale (A). En particulier, la présente invention concerne un procédé amélioré de fabrication de Lacosamide (LCM), (R)-2-acétamido-N-benzyl-3-méthoxypropion-amide (B1), pouvant être employé en tant que médicament antiépileptique.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDANCPJ3dg0OVnDzD1II8XBVCAhyDXAMcgzx9PdT8HdTcPT19PNXcHT2dFFwcQ3yDANKhLkG8zCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-HB_IwNDIwMTQ0sLM0dDY-JUAQB_nyh6</recordid><startdate>20120405</startdate><enddate>20120405</enddate><creator>MERSCHAERT, ALAIN</creator><creator>BOUVY, DIDIER</creator><creator>VASSELIN, DAVID</creator><creator>CARLY, NICOLAS</creator><scope>EVB</scope></search><sort><creationdate>20120405</creationdate><title>PROCESS FOR THE PREPARATION OF AMINO ACID DERIVATIVES</title><author>MERSCHAERT, ALAIN ; BOUVY, DIDIER ; VASSELIN, DAVID ; CARLY, NICOLAS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2012041986A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2012</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>MERSCHAERT, ALAIN</creatorcontrib><creatorcontrib>BOUVY, DIDIER</creatorcontrib><creatorcontrib>VASSELIN, DAVID</creatorcontrib><creatorcontrib>CARLY, NICOLAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MERSCHAERT, ALAIN</au><au>BOUVY, DIDIER</au><au>VASSELIN, DAVID</au><au>CARLY, NICOLAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR THE PREPARATION OF AMINO ACID DERIVATIVES</title><date>2012-04-05</date><risdate>2012</risdate><abstract>The present invention relates to a process of manufacture of compounds of formula (B) wherein R1, R2 and R3 are as defined for compounds of formula (A), which process comprises hydrogenation of compounds of general formula (A). In particular, the present invention relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (B1), which is useful as an anticonvulsive drug.
La présente invention concerne un procédé de fabrication de composés de formule (B) où R1, R2 et R3 sont tels que définis pour les composés de formule (A), ledit procédé comprenant l'hydrogénation de composés de formule générale (A). En particulier, la présente invention concerne un procédé amélioré de fabrication de Lacosamide (LCM), (R)-2-acétamido-N-benzyl-3-méthoxypropion-amide (B1), pouvant être employé en tant que médicament antiépileptique.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PROCESS FOR THE PREPARATION OF AMINO ACID DERIVATIVES |
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