TRIAZOLOPYRAZINONES AS P2X7 RECEPTOR ANTAGONISTS

The invention provides certain 3,7-disubstituted-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-ones of the Formula (I), and their pharmaceutically acceptabl salts, wherein R1, R2, R3, R8, and X are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and method...

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Bibliographische Detailangaben
Hauptverfasser:	CZARNIECKI, MICHAEL, F, POKER, CORY SETH, LABROLI, MARC
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention provides certain 3,7-disubstituted-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-ones of the Formula (I), and their pharmaceutically acceptabl salts, wherein R1, R2, R3, R8, and X are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating pain or an inflammatory disease. L'invention concerne certaines 3,7-disubstituées-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-ones de formule (I), et leurs sels pharmaceutiquement acceptables, R1, R2, R3, R8, et X étant comme définis ici. L'invention concerne aussi des compositions pharmaceutiques comprenant ces composés, et des procédés d'utilisation des composés pour traiter la douleur ou une maladie inflammatoire.