DIAGNOSIS OF BACTERIAL MENINGITIS BASED ON THE MEASURE OF ROS PRODUCTION IN A SAMPLE OF CEREBROSPINAL FLUID
The present invention pertains to a method for in vitro diagnosing a bacterial infection in a biological fluid selected amongst cerebrospinal fluid, ascitic fluid, pericardial fluid, pleural fluid, urine and synovial fluid, based on the measure, in a sample of said fluid, of the production of reacti...
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| creator | LUKASZEWICZ, ANNE-CLAIRE OUANOUNOU, INGRID PAYEN DE LA GARANDERIE, DIDIER |
| description | The present invention pertains to a method for in vitro diagnosing a bacterial infection in a biological fluid selected amongst cerebrospinal fluid, ascitic fluid, pericardial fluid, pleural fluid, urine and synovial fluid, based on the measure, in a sample of said fluid, of the production of reactive oxygen species (ROS); a high level of ROS production is indicative of the presence of activated polymorphonuclear neutrophils (PMNs) in said fluid, which in turn is a hallmark of bacterial infection.
La présente invention concerne un procédé de diagnostic in vitro d'une infection bactérienne dans un fluide biologique choisi parmi le liquide céphalorachidien, le liquide d'ascite, le liquide péricardique, le liquide pleural, l'urine et le liquide sinovial, sur la base de la mesure, dans un échantillon dudit fluide, de la production de dérivés réactifs de l'oxygène (DRO) ; un niveau élevé de production de DRO est indicateur de la présence de neutrophiles polymorphonucléaires activés (PMN) dans ledit fluide, qui est à son tour la marque d'une infection bactérienne. |
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La présente invention concerne un procédé de diagnostic in vitro d'une infection bactérienne dans un fluide biologique choisi parmi le liquide céphalorachidien, le liquide d'ascite, le liquide péricardique, le liquide pleural, l'urine et le liquide sinovial, sur la base de la mesure, dans un échantillon dudit fluide, de la production de dérivés réactifs de l'oxygène (DRO) ; un niveau élevé de production de DRO est indicateur de la présence de neutrophiles polymorphonucléaires activés (PMN) dans ledit fluide, qui est à son tour la marque d'une infection bactérienne.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120518&DB=EPODOC&CC=WO&NR=2012014156A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120518&DB=EPODOC&CC=WO&NR=2012014156A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LUKASZEWICZ, ANNE-CLAIRE</creatorcontrib><creatorcontrib>OUANOUNOU, INGRID</creatorcontrib><creatorcontrib>PAYEN DE LA GARANDERIE, DIDIER</creatorcontrib><title>DIAGNOSIS OF BACTERIAL MENINGITIS BASED ON THE MEASURE OF ROS PRODUCTION IN A SAMPLE OF CEREBROSPINAL FLUID</title><description>The present invention pertains to a method for in vitro diagnosing a bacterial infection in a biological fluid selected amongst cerebrospinal fluid, ascitic fluid, pericardial fluid, pleural fluid, urine and synovial fluid, based on the measure, in a sample of said fluid, of the production of reactive oxygen species (ROS); a high level of ROS production is indicative of the presence of activated polymorphonuclear neutrophils (PMNs) in said fluid, which in turn is a hallmark of bacterial infection.
La présente invention concerne un procédé de diagnostic in vitro d'une infection bactérienne dans un fluide biologique choisi parmi le liquide céphalorachidien, le liquide d'ascite, le liquide péricardique, le liquide pleural, l'urine et le liquide sinovial, sur la base de la mesure, dans un échantillon dudit fluide, de la production de dérivés réactifs de l'oxygène (DRO) ; un niveau élevé de production de DRO est indicateur de la présence de neutrophiles polymorphonucléaires activés (PMN) dans ledit fluide, qui est à son tour la marque d'une infection bactérienne.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjM0KwjAQhHPxIOo7LHgWrNXet8m2XWiTkh88liLxomihvj9G8QGEgYH5PmYpboqx1saxA1NBidKTZWyhI826Zp_2Eh0pMBp8Q2lHFyx9ZGsc9NaoID0nyhoQHHZ9-6WSLJVJ6Vmnu6oNrNZicR3vc9z8eiW2FXnZ7OL0HOI8jZf4iK_hbA77LOWYnQrM8_-sN1OnNtE</recordid><startdate>20120518</startdate><enddate>20120518</enddate><creator>LUKASZEWICZ, ANNE-CLAIRE</creator><creator>OUANOUNOU, INGRID</creator><creator>PAYEN DE LA GARANDERIE, DIDIER</creator><scope>EVB</scope></search><sort><creationdate>20120518</creationdate><title>DIAGNOSIS OF BACTERIAL MENINGITIS BASED ON THE MEASURE OF ROS PRODUCTION IN A SAMPLE OF CEREBROSPINAL FLUID</title><author>LUKASZEWICZ, ANNE-CLAIRE ; OUANOUNOU, INGRID ; PAYEN DE LA GARANDERIE, DIDIER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2012014156A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2012</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LUKASZEWICZ, ANNE-CLAIRE</creatorcontrib><creatorcontrib>OUANOUNOU, INGRID</creatorcontrib><creatorcontrib>PAYEN DE LA GARANDERIE, DIDIER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LUKASZEWICZ, ANNE-CLAIRE</au><au>OUANOUNOU, INGRID</au><au>PAYEN DE LA GARANDERIE, DIDIER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DIAGNOSIS OF BACTERIAL MENINGITIS BASED ON THE MEASURE OF ROS PRODUCTION IN A SAMPLE OF CEREBROSPINAL FLUID</title><date>2012-05-18</date><risdate>2012</risdate><abstract>The present invention pertains to a method for in vitro diagnosing a bacterial infection in a biological fluid selected amongst cerebrospinal fluid, ascitic fluid, pericardial fluid, pleural fluid, urine and synovial fluid, based on the measure, in a sample of said fluid, of the production of reactive oxygen species (ROS); a high level of ROS production is indicative of the presence of activated polymorphonuclear neutrophils (PMNs) in said fluid, which in turn is a hallmark of bacterial infection.
La présente invention concerne un procédé de diagnostic in vitro d'une infection bactérienne dans un fluide biologique choisi parmi le liquide céphalorachidien, le liquide d'ascite, le liquide péricardique, le liquide pleural, l'urine et le liquide sinovial, sur la base de la mesure, dans un échantillon dudit fluide, de la production de dérivés réactifs de l'oxygène (DRO) ; un niveau élevé de production de DRO est indicateur de la présence de neutrophiles polymorphonucléaires activés (PMN) dans ledit fluide, qui est à son tour la marque d'une infection bactérienne.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | DIAGNOSIS OF BACTERIAL MENINGITIS BASED ON THE MEASURE OF ROS PRODUCTION IN A SAMPLE OF CEREBROSPINAL FLUID |
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