DIAGNOSIS OF BACTERIAL MENINGITIS BASED ON THE MEASURE OF ROS PRODUCTION IN A SAMPLE OF CEREBROSPINAL FLUID

The present invention pertains to a method for in vitro diagnosing a bacterial infection in a biological fluid selected amongst cerebrospinal fluid, ascitic fluid, pericardial fluid, pleural fluid, urine and synovial fluid, based on the measure, in a sample of said fluid, of the production of reacti...

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Bibliographische Detailangaben
Hauptverfasser:	LUKASZEWICZ, ANNE-CLAIRE, OUANOUNOU, INGRID, PAYEN DE LA GARANDERIE, DIDIER
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention pertains to a method for in vitro diagnosing a bacterial infection in a biological fluid selected amongst cerebrospinal fluid, ascitic fluid, pericardial fluid, pleural fluid, urine and synovial fluid, based on the measure, in a sample of said fluid, of the production of reactive oxygen species (ROS); a high level of ROS production is indicative of the presence of activated polymorphonuclear neutrophils (PMNs) in said fluid, which in turn is a hallmark of bacterial infection. La présente invention concerne un procédé de diagnostic in vitro d'une infection bactérienne dans un fluide biologique choisi parmi le liquide céphalorachidien, le liquide d'ascite, le liquide péricardique, le liquide pleural, l'urine et le liquide sinovial, sur la base de la mesure, dans un échantillon dudit fluide, de la production de dérivés réactifs de l'oxygène (DRO) ; un niveau élevé de production de DRO est indicateur de la présence de neutrophiles polymorphonucléaires activés (PMN) dans ledit fluide, qui est à son tour la marque d'une infection bactérienne.