RADIATION SENSITIZATION AGENTS FOR PROSTATE CANCER
Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of radiosensitizing genes in neoplastic cells expressing a cell surface molecule that binds the aptamer. L&...
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| creator | NI, XIAOHUA DEWEESE, THEODORE, L ZHANG, YONGGANG LUPOLD, SHAWN, EDWARD |
| description | Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of radiosensitizing genes in neoplastic cells expressing a cell surface molecule that binds the aptamer.
L'invention concerne des compositions et des méthodes de sensibilisation de cellules néoplasiques à la radiothérapie. L'invention concerne des chimères d'acides nucléiques inhibiteurs d'aptamères qui inhibent sélectivement l'expression de gènes radiosensibilisants dans des cellules néoplasiques exprimant une molécule de surface cellulaire qui se lie à l'aptamère. |
| format | Patent |
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L'invention concerne des compositions et des méthodes de sensibilisation de cellules néoplasiques à la radiothérapie. L'invention concerne des chimères d'acides nucléiques inhibiteurs d'aptamères qui inhibent sélectivement l'expression de gènes radiosensibilisants dans des cellules néoplasiques exprimant une molécule de surface cellulaire qui se lie à l'aptamère.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120126&DB=EPODOC&CC=WO&NR=2012012710A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120126&DB=EPODOC&CC=WO&NR=2012012710A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NI, XIAOHUA</creatorcontrib><creatorcontrib>DEWEESE, THEODORE, L</creatorcontrib><creatorcontrib>ZHANG, YONGGANG</creatorcontrib><creatorcontrib>LUPOLD, SHAWN, EDWARD</creatorcontrib><title>RADIATION SENSITIZATION AGENTS FOR PROSTATE CANCER</title><description>Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of radiosensitizing genes in neoplastic cells expressing a cell surface molecule that binds the aptamer.
L'invention concerne des compositions et des méthodes de sensibilisation de cellules néoplasiques à la radiothérapie. L'invention concerne des chimères d'acides nucléiques inhibiteurs d'aptamères qui inhibent sélectivement l'expression de gènes radiosensibilisants dans des cellules néoplasiques exprimant une molécule de surface cellulaire qui se lie à l'aptamère.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAKcnTxdAzx9PdTCHb1C_YM8YyC8BzdXf1CghXc_IMUAoL8g0McQ1wVnB39nF2DeBhY0xJzilN5oTQ3g7Kba4izh25qQX58anFBYnJqXmpJfLi_kYEhCJkbGjgaGROnCgAx-ifh</recordid><startdate>20120126</startdate><enddate>20120126</enddate><creator>NI, XIAOHUA</creator><creator>DEWEESE, THEODORE, L</creator><creator>ZHANG, YONGGANG</creator><creator>LUPOLD, SHAWN, EDWARD</creator><scope>EVB</scope></search><sort><creationdate>20120126</creationdate><title>RADIATION SENSITIZATION AGENTS FOR PROSTATE CANCER</title><author>NI, XIAOHUA ; DEWEESE, THEODORE, L ; ZHANG, YONGGANG ; LUPOLD, SHAWN, EDWARD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2012012710A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2012</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>NI, XIAOHUA</creatorcontrib><creatorcontrib>DEWEESE, THEODORE, L</creatorcontrib><creatorcontrib>ZHANG, YONGGANG</creatorcontrib><creatorcontrib>LUPOLD, SHAWN, EDWARD</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NI, XIAOHUA</au><au>DEWEESE, THEODORE, L</au><au>ZHANG, YONGGANG</au><au>LUPOLD, SHAWN, EDWARD</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>RADIATION SENSITIZATION AGENTS FOR PROSTATE CANCER</title><date>2012-01-26</date><risdate>2012</risdate><abstract>Compositions and methods are provided for sensitizing neoplastic cells to radiotherapy. The invention provides aptamer-inhibitory nucleic acid chimeras that selectively inliibit the expression of radiosensitizing genes in neoplastic cells expressing a cell surface molecule that binds the aptamer.
L'invention concerne des compositions et des méthodes de sensibilisation de cellules néoplasiques à la radiothérapie. L'invention concerne des chimères d'acides nucléiques inhibiteurs d'aptamères qui inhibent sélectivement l'expression de gènes radiosensibilisants dans des cellules néoplasiques exprimant une molécule de surface cellulaire qui se lie à l'aptamère.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | RADIATION SENSITIZATION AGENTS FOR PROSTATE CANCER |
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