SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF
This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R2a, R2b, R2c and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the comp...
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| creator | CALDERWOOD, EMILY, F GOULD, ALEXANDRA, E MA, LITING ENGLAND, DYLAN, B HARRISON, SEAN, J |
| description | This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R2a, R2b, R2c and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
Cette invention concerne des composés de formule (I), utiles comme inhibiteurs de HDAC6. Dans ladite formule, R1a, R1b, R1c, R2a, R2b, R2c et R2d ont les valeurs indiquées dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention et des méthodes d'utilisation de ces compositions dans le traitement de maladies ou affections prolifératives, inflammatoires, infectieuses, neurologiques ou cardiovasculaires. |
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Cette invention concerne des composés de formule (I), utiles comme inhibiteurs de HDAC6. Dans ladite formule, R1a, R1b, R1c, R2a, R2b, R2c et R2d ont les valeurs indiquées dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention et des méthodes d'utilisation de ces compositions dans le traitement de maladies ou affections prolifératives, inflammatoires, infectieuses, neurologiques ou cardiovasculaires.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120126&DB=EPODOC&CC=WO&NR=2012012320A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120126&DB=EPODOC&CC=WO&NR=2012012320A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CALDERWOOD, EMILY, F</creatorcontrib><creatorcontrib>GOULD, ALEXANDRA, E</creatorcontrib><creatorcontrib>MA, LITING</creatorcontrib><creatorcontrib>ENGLAND, DYLAN, B</creatorcontrib><creatorcontrib>HARRISON, SEAN, J</creatorcontrib><title>SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF</title><description>This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R2a, R2b, R2c and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
Cette invention concerne des composés de formule (I), utiles comme inhibiteurs de HDAC6. Dans ladite formule, R1a, R1b, R1c, R2a, R2b, R2c et R2d ont les valeurs indiquées dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention et des méthodes d'utilisation de ces compositions dans le traitement de maladies ou affections prolifératives, inflammatoires, infectieuses, neurologiques ou cardiovasculaires.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNANDnUKDvEMCQ1xdVHwiHQJ8o9w9PV0VnB09nQJVnD0c1EIDXYNVgjxcA1y9XfjYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBoYgZGxk4GhoTJwqAGPNJlo</recordid><startdate>20120126</startdate><enddate>20120126</enddate><creator>CALDERWOOD, EMILY, F</creator><creator>GOULD, ALEXANDRA, E</creator><creator>MA, LITING</creator><creator>ENGLAND, DYLAN, B</creator><creator>HARRISON, SEAN, J</creator><scope>EVB</scope></search><sort><creationdate>20120126</creationdate><title>SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF</title><author>CALDERWOOD, EMILY, F ; GOULD, ALEXANDRA, E ; MA, LITING ; ENGLAND, DYLAN, B ; HARRISON, SEAN, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2012012320A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2012</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>CALDERWOOD, EMILY, F</creatorcontrib><creatorcontrib>GOULD, ALEXANDRA, E</creatorcontrib><creatorcontrib>MA, LITING</creatorcontrib><creatorcontrib>ENGLAND, DYLAN, B</creatorcontrib><creatorcontrib>HARRISON, SEAN, J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CALDERWOOD, EMILY, F</au><au>GOULD, ALEXANDRA, E</au><au>MA, LITING</au><au>ENGLAND, DYLAN, B</au><au>HARRISON, SEAN, J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF</title><date>2012-01-26</date><risdate>2012</risdate><abstract>This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R2a, R2b, R2c and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
Cette invention concerne des composés de formule (I), utiles comme inhibiteurs de HDAC6. Dans ladite formule, R1a, R1b, R1c, R2a, R2b, R2c et R2d ont les valeurs indiquées dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention et des méthodes d'utilisation de ces compositions dans le traitement de maladies ou affections prolifératives, inflammatoires, infectieuses, neurologiques ou cardiovasculaires.</abstract><oa>free_for_read</oa></addata></record> |
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| title | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF |
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