THREE COMPONENT CO-CRYSTAL FORMATION BETWEEN DIASTEREOMERIC MIXTURES OF 3-ALKYL-4-((S)-1'PHENYLETHYLAMINO) BUTANOIC ACID AND OPTICALLY PURE 1, 1'-BI-2-NAPHTHOL
A ternary co-crystal consisting of 1 :0.5:0.5 molar proportion of (S)-1,1'-bi-2-naphthol, 3(S)-propyl-4-[(S)1 '-phenyl-ethylamino]-butanoic acid and 3(R)-propyl-4-[(S)1'- phenyl-ethylamino]-butanoic acid having characteristic powder X-ray diffraction pattern with 2T values of 8.41, 9....
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| creator | SINGH, GIRIJ, PAL LATHI, PIYUSH, SURESH MITRA, RANGAN ROY, BHAIRAB, NATH |
| description | A ternary co-crystal consisting of 1 :0.5:0.5 molar proportion of (S)-1,1'-bi-2-naphthol, 3(S)-propyl-4-[(S)1 '-phenyl-ethylamino]-butanoic acid and 3(R)-propyl-4-[(S)1'- phenyl-ethylamino]-butanoic acid having characteristic powder X-ray diffraction pattern with 2T values of 8.41, 9.38, 10.32, 12.16, 15.52, 15.51, 17.84, 17.95, 19.16, 20.37, 21.74, 22.55, 24.44, 25.65, 28.40, 29.15, 29.69, 31.31, 33.54, 34.40, 35.43 (±0.2) and having differential scanning calorimetric peak at about 189.23 ° C when analyzed at the rate of heating of 10°C per minute and process for preparing the same. A process for resolution of (S)-1,1'-bi-2-naphthol from RS-1,1'-bi-2-naphthol.
Cette invention concerne un co-cristal ternaire constitué de (S)-1,1'-bi-2-naphtol, acide 3(S)-propyl-4-[(S)-1'-phényléthylamino]- butanoïque et acide 3(R)-propyl-4-[(S)-1'-phényléthylamino]butanoïque dans un rapport en moles de 1:0,5:0,5, ayant un diagramme de diffraction des rayons X sur poudre caractéristique présentant des valeurs 2? de 8,41, 9,38, 10,32, 12,16, 15,52, 15,51, 17,84, 17,95, 19,16, 20,37, 21,74, 22,55, 24,44, 25,65, 28,40, 29,15, 29,69, 31,31, 33,54, 34,40, 35,43 (±0,2) et un pic en analyse calorimétrique différentielle d'environ 189,23°C quand il est analysé à une vitesse de chauffage de 10°C par minute. Cette invention concerne également un procédé de préparation dudit co-cristal ternaire et un procédé de dédoublement du (S)-1,1'-bi-2-naphtol à partir du RS-1,1'-bi-2-naphtol. |
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Cette invention concerne un co-cristal ternaire constitué de (S)-1,1'-bi-2-naphtol, acide 3(S)-propyl-4-[(S)-1'-phényléthylamino]- butanoïque et acide 3(R)-propyl-4-[(S)-1'-phényléthylamino]butanoïque dans un rapport en moles de 1:0,5:0,5, ayant un diagramme de diffraction des rayons X sur poudre caractéristique présentant des valeurs 2? de 8,41, 9,38, 10,32, 12,16, 15,52, 15,51, 17,84, 17,95, 19,16, 20,37, 21,74, 22,55, 24,44, 25,65, 28,40, 29,15, 29,69, 31,31, 33,54, 34,40, 35,43 (±0,2) et un pic en analyse calorimétrique différentielle d'environ 189,23°C quand il est analysé à une vitesse de chauffage de 10°C par minute. Cette invention concerne également un procédé de préparation dudit co-cristal ternaire et un procédé de dédoublement du (S)-1,1'-bi-2-naphtol à partir du RS-1,1'-bi-2-naphtol.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120119&DB=EPODOC&CC=WO&NR=2012007814A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120119&DB=EPODOC&CC=WO&NR=2012007814A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SINGH, GIRIJ, PAL</creatorcontrib><creatorcontrib>LATHI, PIYUSH, SURESH</creatorcontrib><creatorcontrib>MITRA, RANGAN</creatorcontrib><creatorcontrib>ROY, BHAIRAB, NATH</creatorcontrib><title>THREE COMPONENT CO-CRYSTAL FORMATION BETWEEN DIASTEREOMERIC MIXTURES OF 3-ALKYL-4-((S)-1'PHENYLETHYLAMINO) BUTANOIC ACID AND OPTICALLY PURE 1, 1'-BI-2-NAPHTHOL</title><description>A ternary co-crystal consisting of 1 :0.5:0.5 molar proportion of (S)-1,1'-bi-2-naphthol, 3(S)-propyl-4-[(S)1 '-phenyl-ethylamino]-butanoic acid and 3(R)-propyl-4-[(S)1'- phenyl-ethylamino]-butanoic acid having characteristic powder X-ray diffraction pattern with 2T values of 8.41, 9.38, 10.32, 12.16, 15.52, 15.51, 17.84, 17.95, 19.16, 20.37, 21.74, 22.55, 24.44, 25.65, 28.40, 29.15, 29.69, 31.31, 33.54, 34.40, 35.43 (±0.2) and having differential scanning calorimetric peak at about 189.23 ° C when analyzed at the rate of heating of 10°C per minute and process for preparing the same. A process for resolution of (S)-1,1'-bi-2-naphthol from RS-1,1'-bi-2-naphthol.
Cette invention concerne un co-cristal ternaire constitué de (S)-1,1'-bi-2-naphtol, acide 3(S)-propyl-4-[(S)-1'-phényléthylamino]- butanoïque et acide 3(R)-propyl-4-[(S)-1'-phényléthylamino]butanoïque dans un rapport en moles de 1:0,5:0,5, ayant un diagramme de diffraction des rayons X sur poudre caractéristique présentant des valeurs 2? de 8,41, 9,38, 10,32, 12,16, 15,52, 15,51, 17,84, 17,95, 19,16, 20,37, 21,74, 22,55, 24,44, 25,65, 28,40, 29,15, 29,69, 31,31, 33,54, 34,40, 35,43 (±0,2) et un pic en analyse calorimétrique différentielle d'environ 189,23°C quand il est analysé à une vitesse de chauffage de 10°C par minute. Cette invention concerne également un procédé de préparation dudit co-cristal ternaire et un procédé de dédoublement du (S)-1,1'-bi-2-naphtol à partir du RS-1,1'-bi-2-naphtol.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDFqAzEQRbdxEZzcYcCFbYhgtTY47ax2FolIGqEd46gyJihVcAzOfXLVbJEDpPqveO8_ND9iMxEYDokjRZlJmVwmQQ8j54DiOEJPciKKMDichDJxoOwMBPcmx0wT8Ag7hf61eLVXm820VXqdLMXiSWzxGFzkLfRHwchzh8YNgHEATuIMel8gzT-gn0GvVe9UpyImK5b9Y7P4uHze69PfLpvVSGKsqrevc73fLu_1Wr_PJ-5a3bXt4UXvsdv9z_oFynREYQ</recordid><startdate>20120119</startdate><enddate>20120119</enddate><creator>SINGH, GIRIJ, PAL</creator><creator>LATHI, PIYUSH, SURESH</creator><creator>MITRA, RANGAN</creator><creator>ROY, BHAIRAB, NATH</creator><scope>EVB</scope></search><sort><creationdate>20120119</creationdate><title>THREE COMPONENT CO-CRYSTAL FORMATION BETWEEN DIASTEREOMERIC MIXTURES OF 3-ALKYL-4-((S)-1'PHENYLETHYLAMINO) BUTANOIC ACID AND OPTICALLY PURE 1, 1'-BI-2-NAPHTHOL</title><author>SINGH, GIRIJ, PAL ; LATHI, PIYUSH, SURESH ; MITRA, RANGAN ; ROY, BHAIRAB, NATH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2012007814A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2012</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>SINGH, GIRIJ, PAL</creatorcontrib><creatorcontrib>LATHI, PIYUSH, SURESH</creatorcontrib><creatorcontrib>MITRA, RANGAN</creatorcontrib><creatorcontrib>ROY, BHAIRAB, NATH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SINGH, GIRIJ, PAL</au><au>LATHI, PIYUSH, SURESH</au><au>MITRA, RANGAN</au><au>ROY, BHAIRAB, NATH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>THREE COMPONENT CO-CRYSTAL FORMATION BETWEEN DIASTEREOMERIC MIXTURES OF 3-ALKYL-4-((S)-1'PHENYLETHYLAMINO) BUTANOIC ACID AND OPTICALLY PURE 1, 1'-BI-2-NAPHTHOL</title><date>2012-01-19</date><risdate>2012</risdate><abstract>A ternary co-crystal consisting of 1 :0.5:0.5 molar proportion of (S)-1,1'-bi-2-naphthol, 3(S)-propyl-4-[(S)1 '-phenyl-ethylamino]-butanoic acid and 3(R)-propyl-4-[(S)1'- phenyl-ethylamino]-butanoic acid having characteristic powder X-ray diffraction pattern with 2T values of 8.41, 9.38, 10.32, 12.16, 15.52, 15.51, 17.84, 17.95, 19.16, 20.37, 21.74, 22.55, 24.44, 25.65, 28.40, 29.15, 29.69, 31.31, 33.54, 34.40, 35.43 (±0.2) and having differential scanning calorimetric peak at about 189.23 ° C when analyzed at the rate of heating of 10°C per minute and process for preparing the same. A process for resolution of (S)-1,1'-bi-2-naphthol from RS-1,1'-bi-2-naphthol.
Cette invention concerne un co-cristal ternaire constitué de (S)-1,1'-bi-2-naphtol, acide 3(S)-propyl-4-[(S)-1'-phényléthylamino]- butanoïque et acide 3(R)-propyl-4-[(S)-1'-phényléthylamino]butanoïque dans un rapport en moles de 1:0,5:0,5, ayant un diagramme de diffraction des rayons X sur poudre caractéristique présentant des valeurs 2? de 8,41, 9,38, 10,32, 12,16, 15,52, 15,51, 17,84, 17,95, 19,16, 20,37, 21,74, 22,55, 24,44, 25,65, 28,40, 29,15, 29,69, 31,31, 33,54, 34,40, 35,43 (±0,2) et un pic en analyse calorimétrique différentielle d'environ 189,23°C quand il est analysé à une vitesse de chauffage de 10°C par minute. Cette invention concerne également un procédé de préparation dudit co-cristal ternaire et un procédé de dédoublement du (S)-1,1'-bi-2-naphtol à partir du RS-1,1'-bi-2-naphtol.</abstract><oa>free_for_read</oa></addata></record> |
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| title | THREE COMPONENT CO-CRYSTAL FORMATION BETWEEN DIASTEREOMERIC MIXTURES OF 3-ALKYL-4-((S)-1'PHENYLETHYLAMINO) BUTANOIC ACID AND OPTICALLY PURE 1, 1'-BI-2-NAPHTHOL |
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