PHARMACEUTICAL COMPOSITION CONTAINING GOSERELIN FOR IN-SITU IMPLANT

The present invention provides a pharmaceutical composition capable of forming in-situ implant comprising goserelin or its pharmaceutically acceptable salts thereof, biodegradable polymer and a biocompatible organic solvent wherein the biocompatible organic solvent is miscible to dispersible in aque...

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Hauptverfasser: NADKARNI, SUNIL, S, PARMAR, ASTHA, ABRAHAM, JAYA, KESARWANI, AMIT
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creator NADKARNI, SUNIL, S
PARMAR, ASTHA
ABRAHAM, JAYA
KESARWANI, AMIT
description The present invention provides a pharmaceutical composition capable of forming in-situ implant comprising goserelin or its pharmaceutically acceptable salts thereof, biodegradable polymer and a biocompatible organic solvent wherein the biocompatible organic solvent is miscible to dispersible in aqueous medium or body fluid. The present invention further provides a process for the preparation of pharmaceutical composition capable of forming in- situ implant. A kit containing composition for in-situ implant is provided comprising a first vial comprising a composition comprising a biodegradable polymer and a biocompatible organic solvent; wherein the biocompatible organic solvent is miscible to dispersible in aqueous medium or body fluid; and a second vial comprising goserelin acetate. La présente invention concerne une composition pharmaceutique capable de former un implant in situ comprenant de la goséréline ou des sels pharmaceutiquement acceptables de celle-ci, un polymère biodégradable et un solvant organique biocompatible, le solvant organique biocompatible étant miscible à dispersible dans un milieu aqueux ou un fluide corporel. La présente invention concerne en outre un procédé de préparation d'une composition pharmaceutique capable de former un implant in situ. La présente invention concerne également une composition contenant un kit pour un implant in situ, qui comprend un premier flacon comprenant une composition comprenant un polymère biodégradable et un solvant organique biocompatible ; le solvant organique biocompatible étant miscible à dispersible dans un milieu aqueux ou un fluide corporel ; et un second flacon comprenant de l'acétate de goséréline.
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The present invention further provides a process for the preparation of pharmaceutical composition capable of forming in- situ implant. A kit containing composition for in-situ implant is provided comprising a first vial comprising a composition comprising a biodegradable polymer and a biocompatible organic solvent; wherein the biocompatible organic solvent is miscible to dispersible in aqueous medium or body fluid; and a second vial comprising goserelin acetate. La présente invention concerne une composition pharmaceutique capable de former un implant in situ comprenant de la goséréline ou des sels pharmaceutiquement acceptables de celle-ci, un polymère biodégradable et un solvant organique biocompatible, le solvant organique biocompatible étant miscible à dispersible dans un milieu aqueux ou un fluide corporel. La présente invention concerne en outre un procédé de préparation d'une composition pharmaceutique capable de former un implant in situ. 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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title PHARMACEUTICAL COMPOSITION CONTAINING GOSERELIN FOR IN-SITU IMPLANT
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