NEW BICYCLIC COMPOUNDS AS PI3-K AND MTOR INHIBITORS

There is provided compounds of formula (I), wherein A1, A4, A4a,A5, B1, B1a, B2, B2a, B3, B3a, B4, B4a and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition...

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Bibliographische Detailangaben
Hauptverfasser:	HIGUERAS HERNANDEZ, ANA ISABEL, ALVAREZ ESCOBAR, ROSA, MARIA, RAMOS LIMA, FRANCISCO, JAVIER, MARTINEZ GONZALES, SONIA, PASTOR FERNANDEZ, JOAQUIN, RODRIGUEZ HERGUETA, ANTONIO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	There is provided compounds of formula (I), wherein A1, A4, A4a,A5, B1, B1a, B2, B2a, B3, B3a, B4, B4a and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. La présente invention a pour objet des composés de formule (I), dans laquelle A1, A4, A4a,A5, B1, B1a, B2, B2a, B3, B3a, B4, B4a et R3 ont les significations données dans la description, et leurs esters, amides, solvates ou sels pharmaceutiquement acceptables, lesquels composés sont utiles dans le traitement de maladies dans lesquelles l'inhibition d'une protéine ou d'une lipide kinase (par exemple une PI3-K et/ou mTOR) est souhaitée et/ou requise, et en particulier dans le traitement du cancer ou d'une maladie proliférative.