METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF CANCER INVOLVING MIRNAS AND MIRNA INHIBITORS AND TARGETS
The present invention relates to microRNAs (miRNAs) which are associated with cancer, particularly including hematologic malignancies, and particularly T-cell acute lymphoblastic leukemia (T-ALL), and to the assessment and modulation thereof in the treatment and management of cancer. The present inv...
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| creator | WOLFE, ANDREW, L SPELEMAN, FRANKI MAVRAKIS, KONSTANTINOS, JOHN PALOMERO, TERESA WENDEL, HANS-GUIDO ORICCHIO, ELISA VAN VLIERBERGHE, PETER FERRANDO, ADOLFO, A DE KEERSMAECKER, KIM |
| description | The present invention relates to microRNAs (miRNAs) which are associated with cancer, particularly including hematologic malignancies, and particularly T-cell acute lymphoblastic leukemia (T-ALL), and to the assessment and modulation thereof in the treatment and management of cancer. The present invention is directed to methods and compositions for diagnosing and treating cancer, particularly T-ALL, by modulating miRNAs, and the use of miRNAs and antagonists thereof, particularly antagomirs, for predicting and assessing response to treatment, in assays for isolating and selecting antagists, and as compositions for the treatment and management of cancer. Methods and compositions are provided for treatment or alleviation of cancer, particularly T-ALL, with antagonists/antagomirs of miRNAs, particularly one or more of miR-19b, miR-20a, miR26, miR92, miR148 and miR223.
La présente invention concerne des microARN (miARN) qui sont associés au cancer, y compris, notamment, des malignités hématologiques, et particulièrement une leucémie lymphoblastique aiguë à cellules T (T-ALL), ainsi que leur évaluation et leur modulation dans le traitement et la prise en charge du cancer. La présente invention concerne des procédés et des compositions destinés au diagnostic et au traitement du cancer, notamment de la T-ALL, par modulation des miARN, et l'utilisation de miARN et de leurs antagonistes, notamment d'antagomirs, pour la prédiction et l'évaluation de la réponse au traitement, dans des tests d'isolement et de choix d'antagonistes, et sous la forme de compositions pour le traitement et la prise en charge du cancer. La présente invention concerne des procédés et des compositions destinées à traiter ou à soulager un cancer, notamment la T-ALL, avec des antagonistes/antagomirs des miARN, notamment un ou plusieurs de miR-19b, miR-20a, miR26, miR92, miR148 et miR223. |
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La présente invention concerne des microARN (miARN) qui sont associés au cancer, y compris, notamment, des malignités hématologiques, et particulièrement une leucémie lymphoblastique aiguë à cellules T (T-ALL), ainsi que leur évaluation et leur modulation dans le traitement et la prise en charge du cancer. La présente invention concerne des procédés et des compositions destinés au diagnostic et au traitement du cancer, notamment de la T-ALL, par modulation des miARN, et l'utilisation de miARN et de leurs antagonistes, notamment d'antagomirs, pour la prédiction et l'évaluation de la réponse au traitement, dans des tests d'isolement et de choix d'antagonistes, et sous la forme de compositions pour le traitement et la prise en charge du cancer. La présente invention concerne des procédés et des compositions destinées à traiter ou à soulager un cancer, notamment la T-ALL, avec des antagonistes/antagomirs des miARN, notamment un ou plusieurs de miR-19b, miR-20a, miR26, miR92, miR148 et miR223.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110901&DB=EPODOC&CC=WO&NR=2011106104A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110901&DB=EPODOC&CC=WO&NR=2011106104A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WOLFE, ANDREW, L</creatorcontrib><creatorcontrib>SPELEMAN, FRANKI</creatorcontrib><creatorcontrib>MAVRAKIS, KONSTANTINOS, JOHN</creatorcontrib><creatorcontrib>PALOMERO, TERESA</creatorcontrib><creatorcontrib>WENDEL, HANS-GUIDO</creatorcontrib><creatorcontrib>ORICCHIO, ELISA</creatorcontrib><creatorcontrib>VAN VLIERBERGHE, PETER</creatorcontrib><creatorcontrib>FERRANDO, ADOLFO, A</creatorcontrib><creatorcontrib>DE KEERSMAECKER, KIM</creatorcontrib><title>METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF CANCER INVOLVING MIRNAS AND MIRNA INHIBITORS AND TARGETS</title><description>The present invention relates to microRNAs (miRNAs) which are associated with cancer, particularly including hematologic malignancies, and particularly T-cell acute lymphoblastic leukemia (T-ALL), and to the assessment and modulation thereof in the treatment and management of cancer. The present invention is directed to methods and compositions for diagnosing and treating cancer, particularly T-ALL, by modulating miRNAs, and the use of miRNAs and antagonists thereof, particularly antagomirs, for predicting and assessing response to treatment, in assays for isolating and selecting antagists, and as compositions for the treatment and management of cancer. Methods and compositions are provided for treatment or alleviation of cancer, particularly T-ALL, with antagonists/antagomirs of miRNAs, particularly one or more of miR-19b, miR-20a, miR26, miR92, miR148 and miR223.
La présente invention concerne des microARN (miARN) qui sont associés au cancer, y compris, notamment, des malignités hématologiques, et particulièrement une leucémie lymphoblastique aiguë à cellules T (T-ALL), ainsi que leur évaluation et leur modulation dans le traitement et la prise en charge du cancer. La présente invention concerne des procédés et des compositions destinés au diagnostic et au traitement du cancer, notamment de la T-ALL, par modulation des miARN, et l'utilisation de miARN et de leurs antagonistes, notamment d'antagomirs, pour la prédiction et l'évaluation de la réponse au traitement, dans des tests d'isolement et de choix d'antagonistes, et sous la forme de compositions pour le traitement et la prise en charge du cancer. La présente invention concerne des procédés et des compositions destinées à traiter ou à soulager un cancer, notamment la T-ALL, avec des antagonistes/antagomirs des miARN, notamment un ou plusieurs de miR-19b, miR-20a, miR26, miR92, miR148 et miR223.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjMEKwjAQRHvxIOo_LHgWmireY7ptFkxWkqUeS5F4Ei20_4_a-gGeZnjzmGU2OhTLZQTtSzDsLhxJiH2EigOIRShR0HzRpEhALQ69AFdgtDcYgHzD54Z8DY6C1_PXVD-TpRMJhxmKDjVKXGeLe_cY0uaXq2xboRi7S_2rTUPf3dIzje2Vi1wplR9VftDF_j_rDYwQOaI</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>WOLFE, ANDREW, L</creator><creator>SPELEMAN, FRANKI</creator><creator>MAVRAKIS, KONSTANTINOS, JOHN</creator><creator>PALOMERO, TERESA</creator><creator>WENDEL, HANS-GUIDO</creator><creator>ORICCHIO, ELISA</creator><creator>VAN VLIERBERGHE, PETER</creator><creator>FERRANDO, ADOLFO, A</creator><creator>DE KEERSMAECKER, KIM</creator><scope>EVB</scope></search><sort><creationdate>20110901</creationdate><title>METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF CANCER INVOLVING MIRNAS AND MIRNA INHIBITORS AND TARGETS</title><author>WOLFE, ANDREW, L ; SPELEMAN, FRANKI ; MAVRAKIS, KONSTANTINOS, JOHN ; PALOMERO, TERESA ; WENDEL, HANS-GUIDO ; ORICCHIO, ELISA ; VAN VLIERBERGHE, PETER ; FERRANDO, ADOLFO, A ; DE KEERSMAECKER, KIM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2011106104A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2011</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WOLFE, ANDREW, L</creatorcontrib><creatorcontrib>SPELEMAN, FRANKI</creatorcontrib><creatorcontrib>MAVRAKIS, KONSTANTINOS, JOHN</creatorcontrib><creatorcontrib>PALOMERO, TERESA</creatorcontrib><creatorcontrib>WENDEL, HANS-GUIDO</creatorcontrib><creatorcontrib>ORICCHIO, ELISA</creatorcontrib><creatorcontrib>VAN VLIERBERGHE, PETER</creatorcontrib><creatorcontrib>FERRANDO, ADOLFO, A</creatorcontrib><creatorcontrib>DE KEERSMAECKER, KIM</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WOLFE, ANDREW, L</au><au>SPELEMAN, FRANKI</au><au>MAVRAKIS, KONSTANTINOS, JOHN</au><au>PALOMERO, TERESA</au><au>WENDEL, HANS-GUIDO</au><au>ORICCHIO, ELISA</au><au>VAN VLIERBERGHE, PETER</au><au>FERRANDO, ADOLFO, A</au><au>DE KEERSMAECKER, KIM</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF CANCER INVOLVING MIRNAS AND MIRNA INHIBITORS AND TARGETS</title><date>2011-09-01</date><risdate>2011</risdate><abstract>The present invention relates to microRNAs (miRNAs) which are associated with cancer, particularly including hematologic malignancies, and particularly T-cell acute lymphoblastic leukemia (T-ALL), and to the assessment and modulation thereof in the treatment and management of cancer. The present invention is directed to methods and compositions for diagnosing and treating cancer, particularly T-ALL, by modulating miRNAs, and the use of miRNAs and antagonists thereof, particularly antagomirs, for predicting and assessing response to treatment, in assays for isolating and selecting antagists, and as compositions for the treatment and management of cancer. Methods and compositions are provided for treatment or alleviation of cancer, particularly T-ALL, with antagonists/antagomirs of miRNAs, particularly one or more of miR-19b, miR-20a, miR26, miR92, miR148 and miR223.
La présente invention concerne des microARN (miARN) qui sont associés au cancer, y compris, notamment, des malignités hématologiques, et particulièrement une leucémie lymphoblastique aiguë à cellules T (T-ALL), ainsi que leur évaluation et leur modulation dans le traitement et la prise en charge du cancer. La présente invention concerne des procédés et des compositions destinés au diagnostic et au traitement du cancer, notamment de la T-ALL, par modulation des miARN, et l'utilisation de miARN et de leurs antagonistes, notamment d'antagomirs, pour la prédiction et l'évaluation de la réponse au traitement, dans des tests d'isolement et de choix d'antagonistes, et sous la forme de compositions pour le traitement et la prise en charge du cancer. La présente invention concerne des procédés et des compositions destinées à traiter ou à soulager un cancer, notamment la T-ALL, avec des antagonistes/antagomirs des miARN, notamment un ou plusieurs de miR-19b, miR-20a, miR26, miR92, miR148 et miR223.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF CANCER INVOLVING MIRNAS AND MIRNA INHIBITORS AND TARGETS |
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