SUSTAINED-RELEASE NSAID/HMG COA REDUCTASE INHIBITOR COMPOSITIONS

Compositions for controlled release of one or more therapeutic agents where the composition is essentially free of excipients are disclosed. In particular, compositions comprising a HMG-CoA reductase inhibitor, particularly simvastatin, and a NSAID, such as a COX-2 inhibitor, particularly celecoxib,...

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Bibliographische Detailangaben
Hauptverfasser:	ASHTON, PAUL, CYNKOWSKI, TADEUSZ, GUO, HONG, CHEN, JIANBING, CYNKOWSKA, GRAZYNA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compositions for controlled release of one or more therapeutic agents where the composition is essentially free of excipients are disclosed. In particular, compositions comprising a HMG-CoA reductase inhibitor, particularly simvastatin, and a NSAID, such as a COX-2 inhibitor, particularly celecoxib, in which greater than 90% of the weight of the composition is made up of the HMG-CoA reductase inhibitor and NSAID are provided. L'invention porte sur des compositions destinées à la libération retardée d'un ou plusieurs agents thérapeutiques, la composition étant essentiellement exempte d'excipients. En particulier, elle porte sur des compositions comprenant un inhibiteur de HMG-CoA reductase, en particulier la simvastatine, et un AINS, tel qu'un inhibiteur de COX-2, en particulier le célécoxib, où plus de 90 % en poids de la composition sont constitués de l'inhibiteur de HMG-CoA reductase et de l'AINS.